Temperature - sensitive mutants with lesions
in the vaccinia virus F10 kinase undergo arrest at the earliest stage of virion morphogenesis.
Elucidating the essential role of the A14 phosphoprotein
in vaccinia virus morphogenesis: construction and characterization of a Tetracycline - inducible recombinant.
Not exact matches
Lederman, who says he's «obsessed» with Jenner and has been working on a biography of the scientist for 20 years, is convinced that Jenner's original vaccine, now named
vaccinia, was derived from a
virus circulating
in horses, not cows, as folklore has it.
In a conversation about one of Evan's earlier
vaccinia papers, Lederman told Evans that he'd love to know whether horsepox still works as a vaccine, but that he had had trouble getting hold of the
virus.
Protein chemist Michael Way, cell biologist Sally Cudmore, and their colleagues at the European Molecular Biology Laboratory
in Heidelberg and at the Pasteur Institute
in Paris have found that
vaccinia — a
virus used
in smallpox vaccines — surfs through cells on piles of actin, one of the basic structural proteins
in the cellular skeleton.
In vivo, primary and secondary cytotoxic T cell responses against
vaccinia and lymphocytic choriomeningitis
virus were within normal ranges.
Both assays (for translation enhancement and internal ribosomal initiation) were validated under cell - free conditions and
in human cells, using a
vaccinia virus vector.
When researchers infected these ERV - depleted cells with the
vaccinia virus (which may be related to smallpox), they had a much weaker innate immune response than unedited normal cells, the team reports online today
in Science.
The standard smallpox vaccine, a
virus called
vaccinia, is amazingly effective, which explains how the disease was eradicated
in the late 1970s.
PANVAC - V, which uses the same
virus as the smallpox vaccine, is a live but weakened
vaccinia vaccine (meaning the
virus can still multiply) that is given
in the arm.
Using a light microscope, researchers at the Swiss Federal Institute of Technology
in Zürich watched fluorescently tagged
vaccinia virus — a more benign cousin of smallpox
virus — migrate toward target cells.
When the
vaccinia virus was delivered
in CIK cells, it was evenly distributed throughout the tumor (left).
Thanks to its resemblance to the smallpox
virus, researchers were able to use
vaccinia as a vaccine for the disease, eventually leading to its eradication
in the late 1970s.
«The novelty here, with
vaccinia, is that it's not just preventing the
virus superinfecting, but physically it's repelling the
virus away,» says Smith, whose team reports its findings today
in Science.
On March 3, 2007, a two - year - old boy suffering from severe eczema and an unusual, widespread rash was transferred from St. Catherine's Hospital,
in East Chicago, IN, to the University of Chicago's Comer Children's Hospital where he was diagnosed with eczema vaccinatum — a rare, severe, adverse reaction to the vaccinia viru
in East Chicago,
IN, to the University of Chicago's Comer Children's Hospital where he was diagnosed with eczema vaccinatum — a rare, severe, adverse reaction to the vaccinia viru
IN, to the University of Chicago's Comer Children's Hospital where he was diagnosed with eczema vaccinatum — a rare, severe, adverse reaction to the
vaccinia virus.
Differences and similarities
in viral life cycle progression and host cell physiology after infection of human dendritic cells with modified
vaccinia virus Ankara and
vaccinia virus.
The Pexa - Vec
virus was originally developed by Michael Mastrangelo, MD, and Edmund Lattime, PhD, of Thomas Jefferson University
in Philadelphia, who engineered the harmless
vaccinia virus to infect only cancer cells and other rapidly dividing cells, as well as to stimulate immune activity,
in hopes of boosting the immune response to tumors.
While at UConn, he researched improvements to the system for generating recombinant
vaccinia viruses in the laboratory of Dr. Paulo Verardi.
Agricola J, Munseri PJ, Nilsson C, Bakari M, Aboud S, Lyamuya EF, Tecleab T, Liakina V, Scarlatti G, Robb, ML, Earl PL, Moss B, Wahren B, Mhalu F, Ferrari G, Sandstrom E, Biberfeld G. Three - year durability of immune responses induced by HIV - DNA and HIV - modified
vaccinia virus Ankara and effect of a late HIV - MVA boost
in Tanzanian volunteers.