Sentences with phrase «in various cell types»

Recently, Rothman and Südhof described the role of the Rab proteins and the SM (Sec1 / Munc18 - like) proteins in providing additional specificity and control to the process of SNARE scaffold assembly and vesicle docking to membranes in various cell types, thus confirming the general importance of these proteins (Science, vol 323, 23 January 2009).

The ability of this gene to modify the other DM1 biomarkers will be explored in various cell types by classical experimental approaches and the molecular mechanism implicated to correct the DM1 missplicings will be analyzed.

It should be straightforward to apply the new library for use in various cell types and in live mice.

In another novel finding, the team demonstrated that ANG achieves these dual functions by inducing RNA processing that is different in various cell types.

Not exact matches

We can compare the diverse tasks performed by a colony to the many proteins generated by gene transcription, to various cell types of a developing embryo, or to the firing patterns of neurons in the brain.

It is emerging that the chemical structure of RNA molecules is extensively modified by specific enzymes normally present in our cells, which are commonly found to be altered in severe medical syndromes and various types of cancers.

In past projects, scientists have tried to derive various types of differentiated cells from stem cells — such as bone, tissue, nerves or fat — directly from hiPSCs.

Slight modifications in their genome sequences play a crucial role in the conversion of pluripotent stem cells into various differentiated cell types.

Since pseudouridine modifications may affect various RNA molecules in different types of normal and malignant cells, «our discoveries pave the way for future avenues of research aimed at exploring the role of pseudouridine in human development disease,» concludes Cristian Bellodi.

The researchers have compared various processes involved in gene expression, such as gene transcription and chromatin modification, and have repeated this in different tissues and cell types from both humans and mice.

In newborn mammals, the SVZ is the biggest depot for the precursor cells that migrate to populate various brain regions, and differentiate into multiple cell types.

At Northwestern University, chemist Samuel Stupp and his research team have developed various types of amphiphile molecules (each end is chemically attracted to a different kind of material) that form self - assembling nanofibers, which in turn can prompt the regeneration of bone and brain cells.

Once stem cells can be grown and differentiated in a controlled way to replace degenerated cells and repair tissues, medical science may then be able to diagnose and cure many intractable diseases at their earliest stages, such as type 1 diabetes, Parkinson's disease, various cardiovascular diseases, liver disease, and cancer.

In a related study, published in Cretaceous Research, OSU scientists announced the first fossil record of Rickettsial - like cells, a bacteria that can cause various types of spotted feveIn a related study, published in Cretaceous Research, OSU scientists announced the first fossil record of Rickettsial - like cells, a bacteria that can cause various types of spotted fevein Cretaceous Research, OSU scientists announced the first fossil record of Rickettsial - like cells, a bacteria that can cause various types of spotted fever.

The three genes, Cas, Eya and Hh, work in various combinations, sometimes repressively, to determine which types of cells are formed.

The lipid type, ceramide, also has a functional role in various signaling pathways and affects synaptic function, although its primary role is not in the synapse, but providing structure in cell membranes.

This ball of cells contains «pluripotent stem cells» — blank slates that can be programed into any type of cell in the body — and researchers are hoping to use these stem cells to treat various conditions, including infertility.

However, no drug can cure infection so far, because various cell types continue to carry the virus in a latent, i.e. quiescent, state.

One of them was used to reproduce acquired aplastic anemia: due to various types of damage, some of the stem cells die, and those that remain need to divide more frequently in order to maintain the production of blood cells; as a result of so many divisions, the telomeres shorten and the disease appears.

Split Pool Ligation - based Transcriptome sequencing (SPLiT - seq) is a scalable technique for characterizing RNA in individual cells that can be used to identify the various cell types found in the brain and other tissues.

Because many different types of cells are active in the liver, the researchers now want to populate the reactor with various combinations of cells.

In addition, they also counted the numbers of various types of single - celled organisms called testate amoebae, whose population changes depending on the amount of water in the bog, giving an indication of how wet or dry the climate was during different periodIn addition, they also counted the numbers of various types of single - celled organisms called testate amoebae, whose population changes depending on the amount of water in the bog, giving an indication of how wet or dry the climate was during different periodin the bog, giving an indication of how wet or dry the climate was during different periods.

«From a health perspective, oxidative stress in the cells causes different types of damage in the body, for example, skin ageing or various infections, contributing to illnesses such as arthritis and Alzheimer's,» says Harri Latva - Mäenpää.

In other words, there is a division of labor among various types of cells within the sponges, which produce the self - organized biological structures through a chain of simple reactions.

In the bone marrow, these cells normally differentiate into various blood cell types.

The UT Southwestern researchers monitored endocytosis in NSCLCs and found significant heterogeneity among the various cell lines, underlining the astounding variety and personal nature of cancer types.

This process, called cell differentiation, gives rise to all the various cell types, such as nerve, muscle, or blood cells, which are diverse in shape and function and make up tissues and organs.

Functional damage to these photoreceptors, or pathological loss of the cells that bear them, results in inability to register light impinging on the retina — and is responsible for various types of visual impairment and certain forms of congenital blindness.

Packed into the nucleus, DNA folds into a functional form that differs in various types of cells.

Christian Seiser says: «Our results highlight that it is crucial to understand the individual role the various HDAC variants in different cell types and hence different types of cancer, before HDAC inhibitors can be used safely as therapeutics.»

Named after the BMP signal protein, this pathway controls the evolution of various cell types depending on the protein concentration, similar to the Wnt pathway, but in a different direction.

Induced pluripotent stem cells can be generated from various types of cells in the body, and they can in turn be coaxed to develop into nearly any other cell type.

And this in spite of the fact that all the various types of blood cells within a lymph node, including the immune cells, are constantly replaced, which means the lymph nodes» location memory must be encoded somewhere in its stroma.

Everyone has urokinase plasminogen activator receptor (uPAR), a healthy molecule «tethered» in place to various types of cells.

Now, a collaboration between the RIKEN Center for Integrative Medical Science (IMS) and other institutions in Japan and Europe have found that in immune cells, simply blocking a transcription factor that leads to differentiation is sufficient to keep cells in a multipotent stem cell - like state where they can continue to proliferate and can later differentiate into various cell types.

For that to happen, a complex, only partially understood interplay takes place between various cell types in our skin.

To test whether the cells would maintain their multipotency in living animals, the researchers transplanted them into mice whose white blood cells had been depleted, and showed that the new cells could expand and differentiate into various types of white blood cells.

A class of therapeutic drugs known as protein kinase inhibitors has in the past decade become a powerful weapon in the fight against various life - threatening diseases, including certain types of leukemia, lung cancer, kidney cancer and squamous cell cancer of the head and neck.

The second experiment is to isolate various cell types from lungs harboring metastasis to confirm the cellular source of periostin in response to metastatic growth.

This series addresses the contribution of cellular senescence to cardiovascular, neurodegenerative, and arthritic disorders as well as the senescent phenotypes in various tissues and cell types.

Korenberg's team is developing a 3D coordinate system to align various types of neuroimaging data in the macaque brain, from whole - brain MRI connectivity to single - cell confocal data and, for some areas, subcellular resolution with electron microscopy.

Our work focuses on discovering and characterizing novel small molecules that can control cell fate and function in numerous cell types, including stem cell maintenance, activation, differentiation, and reprogramming in various developmental stages and tissues.

An anti-PD-1 antibody developed by Bristol - Myers Squibb generates excitement with results from a phase I trial showing that, among 236 patients with various types of cancer, the treatment shrank tumors in 28 percent of melanoma patients, 30 percent of patients with kidney cancer, and 18 percent of patients with advanced non-small cell lung cancer.

Among the strengths of the study: instead of using just one method to deplete macrophages, the researchers used nine distinct methods to deplete different myeloid cells in various locations, allowing them to pinpoint the most important cell type and its primary location of action.

To identify the molecular mechanisms of neural stem cell plasticity in adult zebrafish brain after various types of tissue damage or physiological stimulations

The CCP also focuses on deciphering the regulatory circuit that controls chromatin organization and maintenance in various stem cell types to determine their functional influence on a cell expression signature and phenotype.

Actins are highly conserved globular proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Malfunctioning regulation of NF - KB has been linked to various types of cancer, including lung cancer, but due to its many functions in the cell, drugs that directly target NF - KB would likely cause severe side effects.

In an apparent world first, Japanese researchers have succeeded in producing intestine from induced pluripotent stem (iPS) cells in mice, which can develop into various types of cells in the bodIn an apparent world first, Japanese researchers have succeeded in producing intestine from induced pluripotent stem (iPS) cells in mice, which can develop into various types of cells in the bodin producing intestine from induced pluripotent stem (iPS) cells in mice, which can develop into various types of cells in the bodin mice, which can develop into various types of cells in the bodin the body.

In addition, in collaboration with the Harvard Medical School bioinformatics team, he discovered (4) how global parameters of the transcriptome differ between various cell typeIn addition, in collaboration with the Harvard Medical School bioinformatics team, he discovered (4) how global parameters of the transcriptome differ between various cell typein collaboration with the Harvard Medical School bioinformatics team, he discovered (4) how global parameters of the transcriptome differ between various cell types.