Sentences with phrase «in vulnerable cells»

Not exact matches

«If you're vulnerable and isolated, the more important that cell phone becomes for you,» says Mark Latonero, a fellow at the Data & Society Research Institute in New York, who has studied technology and human trafficking.

«We suspected that the young are most vulnerable because of their immature immune systems, but we didn't have a lot of hard evidence to show that before,» said study lead author Bo Hang, a Berkeley Lab staff scientist who previously found that thirdhand smoke could lead to genetic mutations in human cells.

That's one of the reasons why inspectors praised the presence of telephones in cells, which allow «vulnerable boys to keep in touch with family and support networks».

And a new analysis of the STEP trial, published last November in Proceedings of the National Academy of Sciences USA, provides a warning that the very vectors (adenoviruses, which are also employed in other vaccine development work) used to distribute the inactive HIV strains can actually make the immune system more vulnerable to infection by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.

Belov already knew that devils in eastern Tasmania are vulnerable because their immune system mistakes foreign cancer cells for «self» cells.

The findings, from the Emory / Johns Hopkins / Florida State team that showed this spring that neural progenitor cells are particularly vulnerable to Zika infection, were published in Nucleic Acid Research.

In the GD2 CAR - T treated animals, the residual cancer cells did not express GD2, suggesting that these remaining cells were not vulnerable to the immune therapy and might be able to cause the cancer to recur.

With the tumor in this vulnerable state, the researchers strike again by shutting down the cell's ability to mitigate the toxic stew it creates from its own deranged metabolism.

By hitting breast cancer cells with a targeted therapeutic immediately after chemotherapy, researchers from Brigham and Women's Hospital (BWH) were able to target cancer cells during a transitional stage when they were most vulnerable, killing cells and shrinking tumors in the lab and in pre-clinical models.

«One - two punch catches cancer cells in vulnerable state.»

And how do occasional cells survive in this vulnerable state — sometimes hiding out in the brain for years — to eventually spawn new tumors?

In a continuation of this work, Goldman is also using mathematical modeling to pursue the most effective dose of chemotherapy to induce the vulnerable transition state of the cancer cell demonstrated in this researcIn a continuation of this work, Goldman is also using mathematical modeling to pursue the most effective dose of chemotherapy to induce the vulnerable transition state of the cancer cell demonstrated in this researcin this research.

«This is a first step,» he says, because it provides a target for therapy: somehow stimulating the SVZ to start replenishing the pool of cells that give rise to the vulnerable, depleted interneurons in CHD.

«Tropical trees, compared those in temperate forests, have three times as many living cells surrounding the xylem that can facilitate these processes, which are not observed by the typical experiments we conduct to determine how vulnerable a plant is to droughts.»

The finding identifies how vulnerable cell groups react and respond differently to the accumulation of mitochondrial DNA damage seen in the disease, highlighting the need for cell - specific treatments.

Dr Elson said: «This is the only study to date to characterise mitochondrial DNA errors in cholinergic neurons, a neuronal population that is highly vulnerable to cell death in Parkinson's disease patients.

The auditory sensory cells in people with impaired pejvakin were observed to be extremely vulnerable to noise.

In some instances, however, the flu virus can prevent the macrophages from carrying out their protective function, allowing the epithelial cells to become vulnerable to infection.

Although that marker, called IL21, had not previously been associated with autoimmune diseases, the gene that produces it sits right in the stretch of DNA known to make these mice vulnerable to diabetes, suggesting that IL21 might make a drug target, says Sarvetnick.Furthermore, by giving the animals a shot of dead bacteria — similar to an immunization in humans — when they were newborns, Sarvetnick and her colleagues prevented a surfeit of CD4 + and CD8 + cells.

Eventually, it may open the door «to provide therapy in the future to reduce the risk» and protect vulnerable cells.

For example, researchers have found that immune cells living in plaques make prostaglandins, key players in inflammation that make the plaques more vulnerable to rupture.

A team at the University of Missouri Bond Life Sciences Center collaborated with scientists at the University of Bonn in Germany to discover genetic evidence that the parasite uses its own version of a key plant hormone and that of the plants to make root cells vulnerable to feeding.

These vulnerable patients, whose immune defenses have taken a dramatic double hit from both their original disease and the treatments required to repopulate their immune system with donor cells, are especially susceptible to a wide range of infections that typically don't cause major problems in healthy people.

This metabolic demand makes brain cells particularly vulnerable to damage from oxidative stress, in which reactive oxygen species (ROS), sometimes called free radicals, exert toxic effects on cellular components.

«Secondary benefits of this trial include the significant improvement in clinical care for children with sickle cell disease at each of the 29 sites because each location had a designated hematologist, neurologist, neuroradiologist and psychologist working as a team to identify and decrease further injury to the brain in this vulnerable population.»

An experimental drug that targets abnormally high levels of a protein linked to cancer growth appears to significantly reduce the proliferation of prostate cancer cells in laboratory cell cultures and animals, while also making these cells considerably more vulnerable to radiation, according to results of a study led by Johns Hopkins scientists.

The virus could actually help, since it would continue infecting and killing unchanged, vulnerable cells — decimating its own resources in the process.

Cardiovascular disease in these young patients develops as vulnerable cells lining the interior of major arteries (vessels that carry blood away from the heart) accumulate the toxic protein and die.

Taking a closer look at the groups of vulnerable motor neurons, the researchers found differences in MMP - 9 expression at the single - cell level.

That could put stress on cells with weakened mitochondria, making them vulnerable to degenerative diseases such as Alzheimer's, geneticist Peter Larsen of Duke University and colleagues proposed February 24 in Alzheimer's & Dementia.

Circumcision is thought to prevent infection because the underside of the foreskin is rich in immune cells that are particularly vulnerable to HIV.

«New treatment targets cancers with particular genetic signature: Mutations in gene SETD2 make cancer cells vulnerable to drug inhibiting the protein WEE1.»

This new finding really helps to explain why neural stem cells are so vulnerable to Zika infection and I hope this can be a first step in determining how we could stop this interaction and disease.

For example, does CVB infection affect cardiac stem cells at any age, or is there a vulnerable period in early childhood?

In a separate set of experiments, Frank showed that the PcrV antibodies prevented the bacterium from shooting its toxin into cells, including macrophages, the immune system's scavenger cells, which are particularly vulnerable to Pseudomonas.

The virus is shown in green, vulnerable neural progenitor cells are shown in red, and neurons are shown in blue.

The inability of cells to differentiate makes them vulnerable to genetic mistakes that drive cancer, since more «stemness» means a tendency toward rapid, abnormal growth seen in tumors.

In some patients who take the cocktail, however, the T cell count remains low, making them vulnerable to opportunistic infections.

The reason may be that their cells divide more times, increasing the chance of malignant mutation in ones that are especially vulnerable, such as cells in the skin.

Those are the cells that respond whenever the room gets dimmer or there are decrements in light; those are the ones that appear to be vulnerable at early stages of the disease and those are also the ones that are going to die first.

(14) The dopamine - producing cells of the SNc are particularly vulnerable to mutations in their mitochondrial genes, and a role for these mutations in PD is widely recognized.

Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), are known to be vulnerable to apoptosis upon various technical manipulation, such as single cell dissociation, freezing and thawing, etc., which hinder their use for clonal isolation in gene transfer, differentiation and FACS cell sorting.

In response, the cells underwent changes indicative of senescence, ceasing cell division and churning out key SASP factors.7 Notably, astrocytes were much more vulnerable to paraquat than skin cells: astrocytes went senescent at a lower concentration of the toxin than was required for skin cells, and the doses that turned skin cells senescent killed astrocytes outright.7

By identifying the critical genes and proteins that are targeted by both pathogens and disease - causing genetic mutations, he hopes to discover the vulnerable points in cells that can be targeted with drugs and potentially treat a multitude of diseases.

A possible hypothesis for exactly how stress contributes is that it may cause a neurotoxic reaction in the brain (primarily in the hippocampus) that leads to cell damage and death in individuals who are already vulnerable (due to genes or early environmental insult).

These range from visual stimulation experiments that allow us to tap into the specific sets of retinal ganglion cells that are most vulnerable early in the disease, to the evolution of new imaging techniques, largely thanks to Alf Dubra and Vivek Srinivasan's work in those areas, and the ability to image retinal ganglion cells and their component parts like their axons which degenerate very early in glaucoma.

Since the goal of huntingtin lowering therapies like IONIS - HTTRx is to reduce the amount of the huntingtin protein in vulnerable brain cells, in theory this gives us a great way to tell whether the drug is doing what it's meant to do.

The most vulnerable cells in HD are brain cells called neurons, about half of the cells in the adult brain.

Larger numbers of senescent cells in a tissue make it more vulnerable to the spread of cancer, contribute to inflammation, and skew the local activity of the immune system.

A Dutch doctor who sent people with multiple sclerosis from the United Kingdom for controversial stem cell injections at his clinic in Rotterdam faces allegations of dishonesty and exploiting vulnerable patients.