Dissociation between Performances
in Water Maze and Spontaneous Alternation in BALB / C versus A / J Mice
Streptozotocin - diabetic rats express deficits
in water maze learning and hippocampal synaptic plasticity.
When administered intraperitoneally to PDGF - AS mice, this conjugate reduced AS neuropathology, neuronal loss, astrogliosis, and behavioral deficits
in the water maze.
J147 and J147 + donepezil rescued the deficit in spatial navigational memory caused by scopolamine
in the water maze but donepezil alone failed to rescue the deficit (Figure 4B).
In the water maze test, the mice needed to elevate themselves onto a platform in a specific location to get out of the water.
At 14 months, however, the J20 / caspase -2 null mice did significantly better
in the water maze test than the J20 mice and similarly to the normal mice.
Afterward, he compares the mental abilities of injured and uninjured rats by testing their reactions to novel and familiar objects (top) and by placing
them in a water maze (bottom).
The mice administered MW108 found the resting platform
in the water maze as quickly as a control group of mice.
The mutant mice had difficulty learning and remembering the location of a hidden platform
in a water maze, which ordinary mice accomplish with ease.
First she deprived juveniles of vision in one eye so that the corresponding brain cells failed to make connections; once the mice reached maturity, they were put
in a water maze that required them to recognize a pattern of fine lines to find a floating platform.
For example, after receiving THC, young mice took longer to learn where a safe platform was hidden
in a water maze, and they had a harder time recognizing another mouse to which they had previously been exposed.
Not exact matches
Young adventurers love to frolic around cascading fountains and crawl through a mix of
water - spraying
mazes, especially
in hot weather.
«They're
in a germ - free facility,» she says apologetically, glancing away from a video
in which a tiny champion powers through a
water maze.
Subsequent analyses of the brains of these animals revealed that the drug reduced the plaques and tangles
in the hippocampus, which is known to play a key role
in learning the
water maze, but not
in the amygdala, which figures importantly
in the dark chamber test.
Mice bred to have a malfunctioning form of CREB, Silva's study demonstrated, did not remember from one day to the next that they had already been taught to navigate a
water maze or that they had previously been placed
in a special cage where they received a mild electric shock.
When the pups get older, they will learn to paddle through
water mazes or bury black marbles
in their bedding, giving researchers insight into how their memory and behavior compare with that of typical mice.
The mice had to swim to a platform
in a memory task called a Morris
Water Maze.
The research was done with laboratory mice that consumed different diets and then faced a variety of tests, such as
water maze testing, to monitor changes
in their mental and physical function, and associated impacts on various types of bacteria.
Indeed, when mice lacking the gene for making IL - 4 take the
water maze test, they do badly, perhaps because their T cells lack a critical signal involved
in fast learning.
In a paper appearing online this week in the early edition of the journal Proceedings of the National Academy of Sciences, University of California, Berkeley, scientists who invented the photoswitch therapy and veterinary colleagues at the School of Veterinary Medicine of the University of Pennsylvania (UPenn) report that blind mice regained the ability to navigate a water maze as well as normal mic
In a paper appearing online this week
in the early edition of the journal Proceedings of the National Academy of Sciences, University of California, Berkeley, scientists who invented the photoswitch therapy and veterinary colleagues at the School of Veterinary Medicine of the University of Pennsylvania (UPenn) report that blind mice regained the ability to navigate a water maze as well as normal mic
in the early edition of the journal Proceedings of the National Academy of Sciences, University of California, Berkeley, scientists who invented the photoswitch therapy and veterinary colleagues at the School of Veterinary Medicine of the University of Pennsylvania (UPenn) report that blind mice regained the ability to navigate a
water maze as well as normal mice.
Hanczyc and his colleagues from Prague have shown that small droplets of alcohol
in water can move through complex
mazes.
An experimental chemical that blocked its action created temporary geniuses: Mice on it were whizzes
in the Morris
water maze.
The scientists confirmed that these mice have learning problems by testing them
in a Morris
water maze, a common lab test of animal learning and memory.
«The Honeycomb
Maze replicates all the advantages of the justly - famous Morris
Water Maze in that it forces the animal to approach a hidden goal from different directions, ruling out non-hippocampal-dependent strategies.
A powerful new tool for the study of spatial memory was today described
in Nature as a significant improvement over the current gold standard, the Morris
Water Maze.
Mice were administered the Morris
water maze test
in an opaque pool with a submerged platform, and humans were administered a virtual version
in a circular field with a buried treasure using a 30 -
in.
Here, we examined the extent to which performance
in the Morris
water maze — the most frequently used behavioral assay of spatial learning and memory
in rodents — translates to humans.
We want you to have software that fits the bill for all of these, from straight - forward protocols such as open field or Morris
water maze testing, to high - throughput testing, such as zebrafish larvae activity monitoring
in 96 - well plates.
A High Fructose Diet Does Not Affect Amphetamine Self - Administration or Spatial
Water Maze Learning and Memory
in Female Rats.
Results from this two - day
water maze show that AD mice take considerably longer to find the hidden platform on Day 2 than AD mice treated with J147 for three months (Figure 1A), demonstrating that J147 significantly improved the spatial navigational memory
in aged, transgenic AD mice.
They have spatial learning and memory defects as assessed
in the Morris
water maze and the radial arm
maze, show developmental delay
in sensorimotor milestones, and exhibit locomotor hyperactivity, lack of behavioral inhibition, and stereotypic behavior.
in 22 degree
water there is increased latency of acquisition of the hidden platform
in the Morris
water maze test
Using a genetic approach to increase spine turnover, they show that higher pre-learning spine turnover positively correlates with learning and memory performance
in contextual fear conditioning and Morris
water maze.
(B) Treatment with scopolamine significantly increased the time taken to find the platform compared to saline controls
in the two day
water maze.
The PD model animals did prove to exhibit substantial
water maze deficits, both
in time to locate the hidden platform and
in time spent
in the target quadrant on the probe test.
In contrast, the current virtual version included the same design and metrics as the
water maze.
Previous adaptations of the Morris
water maze for humans varied significantly from the original
in their design and performance measures.
Water maze learning and hippocampal synaptic plasticity
in streptozotocin - diabetic rats: effects of insulin treatment.
This video will summarize principles of Morris
Water Maze testing review procedures for setting up and running the test and highlight some ways that this and other water tests are used in lab stu
Water Maze testing review procedures for setting up and running the test and highlight some ways that this and other
water tests are used in lab stu
water tests are used
in lab studies.
Since
water is very effective
in encouraging rodents to explore a
maze, it's no surprise that many
water - based
maze variants exist.
The Morris
water maze is a valuable tool to study learning and memory
in rodents.
We here studied,
in intact young and aged adult mice, drinking -
water (1μM) estradiol effects on both retention and organizational components of hippocampus - dependent memory, using a radial -
maze task of everyday - like memory.
The difference
in results obtained
in the two tasks designed to test reference memory (cross
maze and
water maze) indicated that the disturbance depended on task difficulty rather than on a particular memory component.
Each animal received 6 daily training trials
in the hidden version of the Morris
water maze (
in blocks of 2 consecutive trials) for 5 consecutive days.
(C) Quadrant occupancy and (D) target crossing measures during the probe trial given after completion of training
in the Morris
water maze.
The Morris
water maze has been extensively used
in mice and rats, but unfortunately people are not necessarily using it correctly or analyzing the data
in the right way.
First constructed
in the 1960s, the state's
maze of tunnels and dams carry melted snowfall and freshwater from Northern California, where two - thirds of
water falls, down to the drier southern part of the state.
The beneficial effects of olibanum on memory deficit induced by hypothyroidism
in adult rats tested
in Morris
water maze.
At this latter time point, all groups presented similar performance
in cognitive tests (Morris
water maze and inhibitory avoidance).
That means I need to find ways to increase BDNF more than
in someone with the normal gene
in order to preserve my cognitive function, memory, and emotional regulation.8 Mu, J.S., et al. «Deprivation of Endogenous Brain - Derived Neurotrophic Factor Results
in Impairment of Spatial Learning and Memory
in Adult... continue 9Cirulli, F., et al. «Intrahippocampal Administration of BDNF
in Adult Rats Affects Short - term Behavioral Plasticity
in the Morris
Water Maze and... continue