Sentences with phrase «in wild type mice»

The baboon quantitative genetics research spun off into a quantitative genetic analysis of dental variation in wild type mice, finding a conserved pattern of genetic modularity (Molecular and Developmental Evolution, 2011, vol 316B: 21 - 49).

In the most extreme case, muscle weights in F66 / Mstn − / − mice were increased by 250 — 350 % from those seen in wild type mice (Figures 2b and 3).

No significant differences in bone growth were seen in wild type mice that received rosuvastatin or vehicle (right and second from right).

In neurons of DIXDC1 mutant mice (center) the dendrites — neural antennae that receive input from other brain cells — have fewer of the dendritic spines (white with red arrows)-- the receiving half of most synaptic inputs — compared to dendrites in wild type mice (left).

«Early during pregnancy, if the mother is infected, there is significant impact on the fetus, even in wild type mice,» she noted.

Not exact matches

Topical application of capsaicin on the dorsal skin of 7,12 - dimetylbenz (a) anthracene — initiated and TPA - promoted TRPV1 wild - type (WT) and TRPV1 knockout (KO) mice induced more and larger skin tumors in TRPV1 / KO mice, suggesting a TRPV1 - independent mechanism.

In wild - type mouse blood vessels, estrogen attenuates vasoconstriction by an ERβ - mediated increase in inducible nitric oxide synthase expressioIn wild - type mouse blood vessels, estrogen attenuates vasoconstriction by an ERβ - mediated increase in inducible nitric oxide synthase expressioin inducible nitric oxide synthase expression.

This study, «Engineered epidermal progenitor cells can correct diet - induced obesity and diabetes,» is the first to show that an engineered skin graft can survive long term in wild - type mice with intact immune systems.

Homozygous MIP - 1 alpha mutant -LRB-- / --RRB- mice were resistant to Coxsackievirus - induced myocarditis seen in infected wild - type (+ / +) mice.

«What we found was, if we block mGluR5, which is the glutamate receptor we're interested in, the mice become hyper locomotive so they become able to move better than wild type mice suggesting glutamate receptors might be a good target for treating movement disorders such as Parkinson's disease.

The study compared intestinal wound healing in two groups of mice: 1) typical mice (wild type) found in nature and 2) mice genetically deficient in the healing factor IL - 10, specifically in macrophages, which impairs their ability to have normal wound repair.

Looking further into the intestinal crypts of both the transgenic and wild - type mice, the research team made what they consider a surprising finding: Not only was HMGA1 causing the stem cells themselves to self - renew or proliferate more rapidly in the transgenic animals, but it was also increasing the number of Paneth cells, a type of niche cell known to support intestinal stem cells.

What surprised us most was that the virus replicated in the vagina of wild - type mice with intact interferon response,» said Iwasaki.

More inflammatory - type T cells and less tolerant - type T cells were found in the colon of mice without gp96 as compared to wild - type mice.

Several years ago, while creating a genetically engineered mouse that expresses high levels of the mouse HMGA1 gene to investigate its role in leukemia, Resar and her colleagues made the chance finding that the intestines of these animals were much larger and heavier than those of «wild - type» animals (or control mice that were not genetically modified).

To explore these questions Akiko Iwasaki, professor of immunobiology and investigator of the Howard Hughes Medical Institute, and her co-authors observed replication of the Zika virus in the vaginal tissue of control, wild - type mice (genetically unmodified mice) and mice lacking genes that regulate immune system proteins known as type I interferons.

Probing the link between adiponectin deficiency and metabolic disorders like diabetes and obesity, researchers from the Albert Einstein College of Medicine in New York City injected adiponectin into wild - type mice, diabetic mice, and obese diabetic mice.

But when the mice were engaged in just one type of learning, humanized and wild mice did equally well on all the tests.

«None of the neurotrophic factor manipulations influenced amyloid deposition, while they all had effects on memory function, also in wild - type mice without amyloid beta pathology,» says Susanna Kemppainen, MSc, who presented the results in her doctoral thesis.

This is because, on treating with the antibiotic ampicillin, no inflammation was observed in wild - type SPF mice with the induction of TH1 cells as described above, but it was caused in IL (interleukin)-10-deficient SPF mice.

After intracerebral injection of the recombinant prion, wild - type mice developed neurological signs in ~ 130 days and reached the terminal stage of disease in ~ 150 days.

In the new work, the researchers fed two common emulsifiers, CMC and polysorbate 80, to both a genetically susceptible mouse strain and wild - type mice — those without genetic mutations that would put them at increased risk of IBD or metabolic syndrome.

The wild - type mice didn't develop colitis, but showed low - grade inflammation in their intestines and several features of metabolic syndrome: slight weight gain, increased body fat and food intake, and higher blood sugar levels, which indicate poor glucose regulation associated with diabetes.

«With normal, wild type bacteria, the mice would die even if you treated them with the antibiotics,» Nguyen said in the podcast.

Specifically, rod - mediated inner retinal responses to dim light flashes were faster in diseased mice than in their wild - type controls.

However, the magnitude of these behavioral responses in knockout mice was 40 % lower than in wild - type mice.

In addition, the researchers reported that MMP - 3 induced blood cell infiltration and hemorrhage after SCI in wild - type mice, but not in Mmp3 knockout micIn addition, the researchers reported that MMP - 3 induced blood cell infiltration and hemorrhage after SCI in wild - type mice, but not in Mmp3 knockout micin wild - type mice, but not in Mmp3 knockout micin Mmp3 knockout mice.

In addition, blood estrogen levels at late stages of pregnancy were found to be about two times higher in Nrk mutant mice than in wild - type mice, suggesting that Nrk is also involved in the regulation of synthesis or secretion of estrogeIn addition, blood estrogen levels at late stages of pregnancy were found to be about two times higher in Nrk mutant mice than in wild - type mice, suggesting that Nrk is also involved in the regulation of synthesis or secretion of estrogein Nrk mutant mice than in wild - type mice, suggesting that Nrk is also involved in the regulation of synthesis or secretion of estrogein wild - type mice, suggesting that Nrk is also involved in the regulation of synthesis or secretion of estrogein the regulation of synthesis or secretion of estrogen.

Induction of the immediate - early gene c - fos was observed after a nighttime light pulse in both wild - type and knockout mice.

Obese mice deficient in TNF - α and iNOS are more sensitive to insulin than are obese wild - type mice (21, 29).

The dashed line represents wheel running data in C57BL / 6 wild - type mice.

Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild - type mice

A team led by parasitologist Stefan Kappe at the Center for Infectious Disease Research in Seattle in Washington gave a rodent version of this «genetically attenuated parasite,» or GAP, to mice and showed that they were completely protected when later infected with an unmodified — or wild - type — version of the same Plasmodium strain.

IL - 15Rα — KO mice also produced a greater number of wheel revolutions than wild - type C57BL / 6 mice, as depicted by the dashed line in Figure 3B.

However, I did obtain a number of female Z116A transgenic mice that were heterozygous for the myostatin mutation, and as shown in Table 1 and Figure 2a, these mice exhibited further increases in muscle weights compared to Z116A mice that were wild type for myostatin.

Numbers represent percent increases relative to wild type mice and were calculated from the data shown in Table 1.

As shown in Table 1, the presence of one or two Mstn mutant alleles in combination with the F66 transgene resulted in increasingly more muscle mass than seen in F66 transgenic mice that were wild type for Mstn.

The researchers have identified a protein — RbAp48 — that, when increased in aged wild - type mice, improves memory back to that of young wild - type mice.

As shown in Table 1, all four lines exhibited significant increases in muscle weights compared to wild type control mice.

C57BL / 6 wild - type mice (The Jackson Laboratory, 000664; n = 8) were used as an additional control for comparison purposes, but were not included in any statistical analyses.

This was further demonstrated by observing a rescue in metastatic efficiency by injecting POSTN - deficient tumor cells into wild - type recipient mice (Malanchi et al., 2012).

Interestingly, Nav1.1 - deficient interneuron transplants were sufficient to cause behavioral abnormalities in wild - type mice, indicating the key functional role of interneurons and Nav1.1 for cognitive functions.

In mouse models, carcinogen - induced tumors that arise in immunodeficient mice, when transplanted to wild - type mice, are usually eliminated by the intact immune system of the new hosIn mouse models, carcinogen - induced tumors that arise in immunodeficient mice, when transplanted to wild - type mice, are usually eliminated by the intact immune system of the new hosin immunodeficient mice, when transplanted to wild - type mice, are usually eliminated by the intact immune system of the new host.

They observed a significant decrease in the number of proliferating stem cells in the brains of HIV / gp120 - mice compared with similar tissue from normal, wild - type mice.

Male or female (5 - 6 wks old) wild type and genetically modified mice (as required for individual investigator's protocols) will be fed a high fat high sucrose diet (from Research Diets ranging in fat from 45 - 58 % of calories as fat, 26 - 39 % carbohydrate (sucrose) and 16 % protein or control diets (10 % fat, 73 % carbohydrate, 16.4 % protein or rodent chow) for up to 16 weeks.

The goal of this protocol (written in French) is to describe the steps and quality controls to prepare new stable murine embryonic stem cells lines: ① either from wild type mouse embryos to introduce a mutation by genetic targeting or homologous recombination to get a genetically modified mouse line ② or from genetically modified mouse embryos with two aims:

The present findings are derived from studies using CD4KO mice and thus, raise the question as to whether the CD4 + T cell - independent immune mechanisms in CD4 KO mice differ from those involved in corneal allograft rejection in wild - type mice whose CD4 + T cells population have been depleted with monoclonal antibodies.

In contrast, tumors induced in wild - type mice often grow when transplanted to other wild - type micIn contrast, tumors induced in wild - type mice often grow when transplanted to other wild - type micin wild - type mice often grow when transplanted to other wild - type mice.

Young mice that expressed high levels of human amyloid - β (but did not have pathological plaques) infected in the brain with Salmonella typhimurium were more likely to survive the infection compared to wild - type mice that did not express the peptide, Tanzi, Moir, and their colleagues found.

Liliana M.; El - Khodor B F.; Hornberger M.; Park, Larry; Howland, David; Brunner D. Effect of the rd1 mutation on motor performance in R6 / 2 and wild type mice [Internet].