Sentences with phrase «in xenograft models»

Terbinafine, a U.S. Food and Drug Administration — approved antifungal drug targeting SQLE, markedly inhibited SQLE - induced NAFLD - HCC cell growth in NAFLD - HCC and HCC cells and attenuated tumor development in xenograft models and in Sqle transgenic mice.

They also found that silencing the ADAR1 gene in the xenograft model reduced multiple myeloma regeneration.

Not exact matches

«This study is important, in part because we now have a new xenograft model that will for the first time allow us to apply new biomarkers to better predict disease progression and test new therapeutics.»

«The ongoing line of work with this drug is an excellent example of the bench getting even closer to the bedside — our lab work with the drug in patient - derived xenograft models of disease makes possible the clinical trials taking place at the University of Colorado Hospital next door,» Jimeno says.

Additional experiments also showed that TiY can suppress the tumor growth in mice xenograft model.

«Our data confirmed that, while the rate of growth of triple - negative breast cancer was not affected by CDK 4/6 inhibitors, this class of drugs was able to significantly inhibit the spread of triple - negative breast cancer to distant organs when tested in multiple different triple - negative breast cancer models, including patient - derived xenografts.»

EZH2 inhibition delayed tumor onset in KDM6A - null cells and caused regression of KDM6A - null bladder tumors in both patient - derived and cell line xenograft models.

We created a mouse xenograft model in which SiHa cervical cancer cells were injected into mice subcutaneously, and the resultant tumors were treated with PAL three times a week for 6 weeks.

We then usually move onto xenograft models and then also, if available, try to test some of these compounds in genetically engineered mouse models that have particular mutations driving tumor formation.

In his current position at The Jackson Laboratory, he has overall responsibility for the ongoing operational development of the PDX resource, which generates, banks, and distributes patient - derived xenograft (PDX) mouse models of human cancers.

In a 1988 paper summarizing his findings, Fiebig concluded that xenograft mice were wonderful models for broadly testing new drugs against human tumors, but they «can not be used as a clinical routine method» for predicting patient treatment.1 The idea of using xenograft mice as personal avatars for cancer patients was discarded.

The researchers used an in vivo model of PARP inhibitor resistance in patient - derived tumor xenografts (PDXs).

Therapeutic efficacy of aldoxorubicin in an intracranial xenograft mouse model of human glioblastoma.

Since starting her new role as an investigator in the In Vivo Pharmacology group at Novartis Oncology, Bhang has been working on using the ClonTracer library to monitor clonal dynamics following drug treatment in cell line and primary tumor xenograft modelin the In Vivo Pharmacology group at Novartis Oncology, Bhang has been working on using the ClonTracer library to monitor clonal dynamics following drug treatment in cell line and primary tumor xenograft modelIn Vivo Pharmacology group at Novartis Oncology, Bhang has been working on using the ClonTracer library to monitor clonal dynamics following drug treatment in cell line and primary tumor xenograft modelin cell line and primary tumor xenograft models.

In 2012 she joined the laboratory of Dr. D.L. Konotyiannis at BSRC AL.Fleming, Greece as postdoctoral scientist, where she worked on the study of the RNA Binding Protein HuR during intestinal and lung inflammation and cancer, using inducible, KO and Tg mouse models and xenografts.

Finally, I have a category of «other cancers» with exomes published in 2011; these include pancreastic cysts and cell lines, gastric cancer tumors, and prostate cancer samples derived through mouse xenograft models.

Patient - derived xenograft models of non-small cell lung cancer and their potential utility in personalized medicine.

In a xenograft KMT2D - mutated T - lymphoma model, dual treatment with chidamide and decitabine significantly retarded tumor growth and induced cell apoptosis through modulation of the KMT2D / H3K4me axis.

(C) In vivo effect of the CHID and DECI combination in a murine T - lymphoma xenograft modeIn vivo effect of the CHID and DECI combination in a murine T - lymphoma xenograft modein a murine T - lymphoma xenograft model.

GLN - 1001 is currently in preclinical development, where it has been shown to dramatically prolong survival in patient derived xenograft animal models of glioblastoma.

(G) Immunostaining of p - ERK in tumor samples of xenografted murine models bearing KMT2D V5486 mutants treated with CHID and / or DECI.

They now show that engineering hESC - and iPSC - derived NK cells with a specific HIV CD4ζ chimeric receptor enhances the suppression of HIV replication in vitro and study these cells in a mouse xenograft model [6].

Flavopiridol inhibits several cellular kinases and has demonstrated cytostatic and cytotoxic activity in vitro and in vivo in numerous human tumor cell lines and xenograft models (including human breast, prostate, and lung carcinoma) at clinically achievable concentrations.

It was indeed found DAXX promotes the in vivo tumorigenicity of two human PCa cell lines in a subcutaneous tumor xenograft model via suppression of autophagy [Submitted].

The in vivo anti-tumor activity of dual treatment on T - cell lymphoma was further evaluated in a murine xenograft model in which KMT2D V5486M mutated Jurkat cells subcutaneously injected into nude mice.

The main research activity (located in central Paris and vicinity at Orsay) regroups to date 16 technology platforms and services offering state ‐ of ‐ the - art expertise and equipment from small molecule chemistry to omcs, super-resolution microscopy, sophisticated radiation sources and various animal models, including xenografts directly derived from patients, in order to promote the best environment and support for research activities.

Acquired tumor cell resistance to sunitinib causes resistance in a HT - 29 human colon cancer xenograft mouse model without affecting sunitinib biodistribution or the tumor microvasculature

Therefore, our NSIN mice provide a new platform for xenograft mouse models in basic and translational research.

We next tested the ability of antibody - expressing NSCs to deliver anti-HER2 antibodies to tumor foci in vivo using a xenograft nude - beige mouse model.

ONC201 combined with cytarabine in a Burkitt's lymphoma xenograft model induced tumor growth inhibition that was superior to either agent alone.

To mimic the in vitro hypoxic response in vivo, we developed a xenograft model based on the hypothesis that with increasing xenograft sizes, there will be a parallel increase in hypoxia due to rapid cell proliferation and restricted blood supply to the xenograft cells.

ONC201 combined with bortezomib in a Burkitt's lymphoma xenograft model reduced tumor cell density and improved CHOP induction compared to either agent alone.

In preclinical trials, the effect of chloroquine and hydroxychloroquine on tumorigenesis has been extensively investigated in mouse cancer models, including genetic and xenograft models (summarized in Table 2In preclinical trials, the effect of chloroquine and hydroxychloroquine on tumorigenesis has been extensively investigated in mouse cancer models, including genetic and xenograft models (summarized in Table 2in mouse cancer models, including genetic and xenograft models (summarized in Table 2in Table 2).

Over 170 carefully curated, well - characterized patient - derived xenograft tumor models are available for use in your facility, or use Horizon's comprehensive preclinical in vivo efficacy service.