Sentences with phrase «in zebrafish models»

Knockdown of dynamin - binding protein or Tuba results in abnormal kidney development and other aberrant phenotypes in zebrafish models (middle and right panels) compared with controls (left panel).

Genetic modification in zebrafish models is cheap and easy, so authors point out that future research on these animal models will contribute to understand the molecular relationship that exists between the proteins involved in the physiopathology of megalencephalic leukoencephalopathy.

Microinjection of wild - type human ACVR1 RNA into alk8 — / — zebrafish embryos rescued approximately 80 % of the injected embryos completely or partially (Figure 3, C and F), showing that human ACVR1 can function as a BMP type I receptor in this zebrafish model and substitute for Alk8.

I am interested in applying fluorescence lifetime imaging microscopy (FLIM) to study the metabolic activity during immune response to pancreatic cancer in a zebrafish model.

In their zebrafish model, the barcode contains 10 20 - base - pair sequences targeted by Cas9 endonuclease, with each of the sequences matching a specific single guide RNA.

C) Angiogenesis assay in the zebrafish model.

In a zebrafish model of cryptococcal disease, a decrease in ERK5 activity led to reduced dissemination of infection by an increase in vomocytosis.

Drug screening in a zebrafish model of SCN1A mutation has identified lead compounds for development of novel therapies.

Not exact matches

More recently, Godinho Ferreira, who now employs three Ph.D. students and four postdocs, has been working to establish Zebrafish as a new model system to try and understand the role of telomeres in aging and the role of telomere - elongation enzymes in cancer.

In an e-mail to Nature a few days later, Kogan said that zebrafish might be a useful model organism for psychiatric disease after all.

«We knew that the brain hat was a very high potential» among marchers, says Chris Pierret, a biologist at the Mayo Clinic in Rochester, but his group commissioned crocheted zebrafish hats, honoring one of their favorite disease research models.

They next tested six randomly selected best - and worst - performing lipidoids in rats and found that the correlation between performance in rats and in zebrafish was 97 percent, suggesting that zebrafish are a good model for predicting drug - delivery success in mammals.

Zebrafish are commonly used to model human diseases, in part because their larvae are transparent, making it easy to see the effects of genetic mutations or drugs.

Together, studies in zebrafish and mammalian models could inform new ways to manipulate glial cells after human spinal cord injury.»

She commented: «Our previous research to validate zebrafish as a model for epilepsy put us in a good position to be able to help the EuroEPINOMICS consortium investigate the function of CHD2.

A simple and inexpensive zebrafish model of concussion, reported in eNeuro, reveals the genetic pathways underlying the animal's remarkable ability to regenerate injured brain tissue.

The zebrafish larva is an ideal model to study genes involved in epilepsy, and the methods necessary for such studies are now well - established in our laboratory.

In addition, the creation of a zebrafish model for CHD2 encephalopathy may facilitate the discovery of new drugs that can treat patients with this form of epilepsy.

Research in the laboratory of Rebecca Wingert, the Gallagher Family Associate Professor of Adult Stem Cell Research in the Department of Biological Sciences at the University of Notre Dame, has confirmed the key role of a certain small molecule in the development of kidney structures in zebrafish, a widely used model for human kidneys.

Zebrafish larvae and fluorescently marked immune cells allow researchers to track immune system activity in a model of retinal degeneration.

To test whether fatty acid levels in the bloodstream was a cause or a consequence of disease, the researchers turned to a zebrafish model of Crohn's disease that had been developed by Stefan Oehlers, a post-doctoral fellow in David Tobin's group at Duke.

His lab is continuing to use the zebrafish as a model organism, but Junker also sees great potential in applying the technique to human organoids.

«Our hope is that by creating this system, we can continue our own investigations into other harmful organisms, and that other scientists worldwide can adapt our zebrafish model to investigate the diseases that are priorities in their communities,» Perfect said.

We have been using cell culture models and zebrafish as an assay to determine the effects of BMP on signaling, but we also want to be able to understand what the effect of the mutation is in the tissue and organ systems.

First, the researchers developed a model of Parkinson's in zebrafish — the first such animal model of the disease — and exposed them to ziram so that they lost dopamine.

The study, published Feb. 16 in PLOS Biology, made use of a mutant zebrafish strain that models human Hirschsprung disease, which is caused by loss of the gut neurons that coordinate gut contractions.

His group studies the cellular and genetic control of gastrulation movements in zebrafish, one of the model organisms studied at the institute besides Drosophila, the C. elegans worm, frogs, mice, and newts.

But overall, the resulting toxicity of the wastewater due to its silver content was negligible to zebrafish embryos — a model animal used in toxicity studies.

Using genetic models in a variety of organisms — yeast, nematodes, fruit flies, zebrafish — PLab aims to identify candidate treatment compounds for each disease, which can then be refined and taken to the clinic with partner companies.

In genetics, the zebrafish is considered an important model organism for studies of vertebrates.

OIST scientists selected the zebrafish as an animal model because its retina is rich in cones and its visual acuity can be measured with a simple device.

«Epilepsy drug discovered in fish model shows promise in small pediatric clinical trial: Research suggests zebrafish models may be efficient resource for identifying drugs for clinical use.»

Now OIST researchers in the Developmental Neurobiology Unit have exposed a similar syndrome in zebrafish, which are an excellent model for studying human diseases.

«Clinical phenotype similarity in megalencephalic leukoencephalopathy patients explained by zebrafish model study.»

Now, a study in the journal Brain describes what could be considered a direct «aquarium - to - bedside» approach, taking a drug discovered in a genetic zebrafish model of epilepsy and testing it, with promising results, in a small number of children with the disease.

In order to understand this contradiction, the research group led by Raúl Estévez and Alejandro Barrallo compared genetically - modified zebrafish and mice models — in other words, knock - out organisms that, in this case, do not express the gene MLC1 — with the brain biopsy from an MLC patienIn order to understand this contradiction, the research group led by Raúl Estévez and Alejandro Barrallo compared genetically - modified zebrafish and mice models — in other words, knock - out organisms that, in this case, do not express the gene MLC1 — with the brain biopsy from an MLC patienin other words, knock - out organisms that, in this case, do not express the gene MLC1 — with the brain biopsy from an MLC patienin this case, do not express the gene MLC1 — with the brain biopsy from an MLC patient.

«Organ development, especially the liver, is highly conserved among vertebrates — including zebrafish — and the mutations we create in zebrafish alter embryogenesis in a manner consistent with humans, making it an ideal model system to study diseases such as Alagille syndrome.»

«We use zebrafish to study Alagille syndrome because these vertebrates allow us to use experimental approaches that aren't possible with other disease models,» says Duc Dong, Ph.D., assistant professor in the Human Genetics Program at SBP and senior author of the paper.

Researchers have pursued alternative therapies for TB using a variety of animal models, including the zebrafish found in many pet stores and household aquariums.

«We tested a drug currently used for cancer treatment (vorinostat (Zolinza)-RRB- and found that it reduced average daily seizures in zebrafish and mouse models by 60 per cent,» says Kurrasch.

By screening commercially available drugs currently being used for other diseases, researchers found vorinostat to be an effective anti-seizure drug in zebrafish and mouse models.

In addition, the significant number (> 1000) novel models that came from RNA - Seq that were absent from the zebrafish cDNAs suggests that the deep sequencing offered by RNA - Seq can be used to expand the gene annotation of even well - studied model organisms.

Rieger used zebrafish larvae to model peripheral neuropathy because the embryos develop rapidly and because the larval fish are translucent, making them ideal for studying the progression of nerve degeneration in live animals.

CELPHEDIA WP1 workgroup gathers experts using CRISPR / Cas9 system in various animal models including mouse, rat, zebrafish and drosophila.

At the Erasmus Medical Center in Rotterdam, the Netherlands, researchers have investigated this movement disorder using a PARK15 (an atypical early - onset parkinsonism) zebrafish model and DanioVision.

Neuroprotective and Neuro - restorative Effects of Minocycline and Rasagiline in a Zebrafish 6 - Hydroxydopamine Model of Parkinson's Disease.

Zebrafish Model is Useful Tool in Identifying Self - renewing Properties of Prostate Cancer Stem Cells Tri-Town News, Greater Media Newspapers — February 6, 2014

The zebrafish is a good choice because of its similarity to humans as a vertebrate, its transparency as an embryo, and the powerful genetic tools available in this model organism.

Zebrafish have only been used as a model organism by a lot of labs in the last 15 years or so.

Zebrafish is a an outstanding model organism to investigate these questions due to its advantages in live imaging and its improving ease of genetic manipulations.