Not exact matches
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth
in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures
in European countries that may increase the amount of discount required on Gilead's products; an increase
in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift
in payer mix to more highly discounted payer segments and geographic regions and decreases
in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations
in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations
in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or
reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials
in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations
in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the
zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates
in the timelines currently anticipated; Gilead's ability to receive regulatory approvals
in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta
in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes
in its stock price, corporate or other market conditions; fluctuations
in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time
in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
Then,
in January 2016,
zinc finally responded to
reduced supply as the big shutdowns at Century, Bathurst, and Lisheen finally took their toll, leading to an advance from US$ 0.65 / lb.
They are a good source of the minerals iron and
zinc, though soaking is paramount
in order to
reduce the inhibitory phytates.
A natural source of complete protein, tofu can help
reduce cholesterol levels, aid
in weight loss, and supply a healthy dose of folate, calcium, magnesium,
zinc, and vitamin K, according to Taub - Dix.
For example, a study of
zinc and magnesium bio-availability
in rats where bio-availability had been
reduced by phytic acid found that «resistant starch restores
zinc bio-availability» and «increased magnesium absorption» (3).
Reduced fat peanut butter is also available, or if you choose a vitamin - fortified brand, such as Peter Pan Plus, it also provides your child with vitamin A, iron, vitamin E, vitamin B6, folic acid, magnesium,
zinc, and copper,
in addition to being a good source of protein.
The recommended routine use of
zinc in the management of childhood diarrhea, not currently practiced
in many countries, is expected to
reduce disease incidence.
In cholera,
zinc is used with the oral rehydration fluids to help
reduce the amount of fluids needed.
Among other things, a subclinical
zinc deficiency
in humans has been attributed to increased levels of inflammation markers and
reduced immunocompetence.
There is no known treatment to correct macular degeneration; until now physicians have focused on trying to
reduce the risk of the disease and keep it
in check with laser treatment, eyewear with special magnifying capabilities, and nutritional supplements including antioxidants and
zinc.
«We are also working on a new mutant that will eliminate an antinutrient present
in wheat — phytic acid — which
reduces the bioavailability of the
zinc and iron present
in the grain.»
PNNL's new
zinc - polyiodide flow battery has a high energy density, which
reduces its size and cost and makes it well suited to store energy
in densely populated cities.
The authors were interested
in whether
zinc supplements could
reduce childhood death and disease, and help support growth.
The drug also appeared to
reduce the amount of the protein amyloid beta (which forms toxic plaques
in the brains of Alzheimer's patients) by decreasing the levels of metals such as
zinc and copper.
Zinc supplements
reduce diarrhea and other infections
in malnourished children, and may prevent death, according to a new study published
in The Cochrane Library.
«However,
in countries where
zinc deficiency is common, supplements may help to
reduce child deaths and related diseases
in the short - term.»
Each ZFP was then fused to a modified FokI cleavage domain, active preferentially as a dimer to
reduce nonspecific DNA cleavage, resulting
in zinc - finger nucleases (ZFNs)[25].
Researchers found that toxic concentrations of
zinc and copper
in water runoff could be
reduced by 10 percent to 20 percent by 2035 if all cities
in the studied watersheds implemented a law similar to the Los Angeles City law that requires new and redevelopment to infiltrate rainwater from a 3 / 4 - inch storm.
Zinc also
reduces keratin production, which helps prevent pores from becoming clogged, kills bacteria on the skin, and even
reduces testosterone — the main hormone that causes acne when
in excess.
The authors published their findings today
in the journal Nature Medicine, concluding that too much dietary
zinc «
reduces the threshold of antibiotics that are needed to convert a resistant microbial community to one that is sensitive to C. diff.»
High levels of phytic acid
in soy
reduce assimilation of calcium, magnesium, copper, iron and
zinc.
These ways include increasing one's vitamin D levels, strength training, losing weight, partaking
in high intensity exercise, consuming plenty of
zinc, greatly limiting or completely eliminating sugar intake,
reducing stress, eating healthy fats and testosterone replacement therapy (TRT).
In fact, one study found that 500 milligrams of spirulina daily combined with
zinc supplementation was enough to
reduce arsenic toxicity by almost half!
The theory that
zinc could be effective for the common cold originated from research performed
in 1984, which revealed that
zinc lozenges can
reduce the length of time symptoms lasted.
These ways include increasing one's vitamin D levels, strength training, losing weight, partaking
in high intensity exercise, consuming plenty of
zinc, greatly limiting or completely eliminating sugar intake,
reducing stress, -LSB-...]
When
zinc is lacking
in a child's diet, his sense of smell is
reduced and food tastes unappetizing.
Because
zinc can help
reduce the amount of sebum (natural oil) your skin produces, some research has found that those with acne have a lower intake of
zinc in their diet than those without acne.
In addition, this study found that zinc supplementation did not significantly reduce the levels of copper or HDL cholesterol in the bod
In addition, this study found that
zinc supplementation did not significantly
reduce the levels of copper or HDL cholesterol
in the bod
in the body.
In addition to its role in the immune system, zinc also reduces oxidative stress, plays a structural role by stabilizing proteins, regulates the expression of many genes, and drives hundreds of chemical reactions in the bod
In addition to its role
in the immune system, zinc also reduces oxidative stress, plays a structural role by stabilizing proteins, regulates the expression of many genes, and drives hundreds of chemical reactions in the bod
in the immune system,
zinc also
reduces oxidative stress, plays a structural role by stabilizing proteins, regulates the expression of many genes, and drives hundreds of chemical reactions
in the bod
in the body.
Treatment with
zinc improved thyroid function and
reduced the incidence of subclinical hypothyroidism
in patients with Down syndrome, who have an increased risk of hypothyroidism (6).
Oral products containing
zinc are also effective
in reducing or inhibiting oral malodor.
Zinc was even shown
in one study to
reduce acne levels by 49.8 %.
Specifically, elite wrestlers were given a daily
zinc supplement during a 4 - week high intensity training routine to
reduce the decline
in testosterone levels from increased stress (28).
For robust leptin function,
reduce the amount of fructose
in your diet to fewer than twenty grams per day and eat
zinc - rich foods such as beans, chicken, oysters, and cashews to balance out leptin.
In a large 2003 government survey known as the Third National Health and Nutrition Examination, or NHANES III, increased intakes of added sugars were found to
reduce the intakes of calcium, vitamin A, iron and
zinc for most age groups.
Zinc works to inhibit the enzyme that converts testosterone into its non-aromatizable form, dihydrotestosterone (DHT), which is how it can
reduce hair loss as well as other symptoms associated with high testosterone levels
in women with PCOS like acne and unwanted hair growth.
The author of another review completed
in 2004 also concluded that
zinc can
reduce the duration and severity of cold symptoms [65].
Zinc supplementation significantly
reduced visual acuity loss
in one of the studies [76] but had no effect
in the other [77].
In addition, they might benefit from using certain food preparation techniques that
reduce the binding of
zinc by phytates and increase its bioavailability.
In addition, results from a pooled analysis of randomized controlled trials of zinc supplementation in developing countries suggest that zinc helps reduce the duration and severity of diarrhea in zinc - deficient or otherwise malnourished children [62
In addition, results from a pooled analysis of randomized controlled trials of
zinc supplementation
in developing countries suggest that zinc helps reduce the duration and severity of diarrhea in zinc - deficient or otherwise malnourished children [62
in developing countries suggest that
zinc helps
reduce the duration and severity of diarrhea
in zinc - deficient or otherwise malnourished children [62
in zinc - deficient or otherwise malnourished children [62].
(18) Specific nutrients
in a whole - foods diet, such as omega - 3 fatty acids, vitamin E, vitamin C, beta - carotene, selenium,
zinc, cryptoxanthin, lycopene, vitamin D, and folate have been found to individually improve semen quality parameters such as sperm concentration and motility by
reducing sperm oxidative damage and inhibiting sperm DNA damage.
In another clinical trial involving 273 participants with experimentally induced colds,
zinc gluconate lozenges (providing 13.3 mg
zinc) significantly
reduced the duration of illness compared with placebo but had no effect on symptom severity [68].
Another example: if you attempt to get your
zinc from whole grains, like bread and pasta, then your body will become highly
zinc deficient (because the
zinc in grains is not absorbed), whereas if you try to get it from seafood like oysters, you will have plenty of it
in your body and your acne will be
reduced.
In a population - based cohort study in the Netherlands, high dietary intake of zinc as well as beta carotene, vitamin C, and vitamin E was associated with reduced risk of AMD in elderly subjects [73
In a population - based cohort study
in the Netherlands, high dietary intake of zinc as well as beta carotene, vitamin C, and vitamin E was associated with reduced risk of AMD in elderly subjects [73
in the Netherlands, high dietary intake of
zinc as well as beta carotene, vitamin C, and vitamin E was associated with
reduced risk of AMD
in elderly subjects [73
in elderly subjects [73].
More recently, a Cochrane review concluded that «
zinc (lozenges or syrup) is beneficial
in reducing the duration and severity of the common cold
in healthy people, when taken within 24 hours of onset of symptoms» [70].
Because breast milk is naturally low
in zinc, it is important for mothers to supplement and consume a high
zinc diet during pregnancy to
reduce the risk of eczema
in infancy.
These ways are with: Diet — eat more fruits and vegetables daily, including: foods rich
in Vitamins A (leafy green vegetables), C (peppers, citrus fruits, berries, tropical fruits, broccoli and tomatoes), and E (almonds, spinach, wheat germ and sweet potato),
Zinc (grass - fed beef, kefir, yogurt, chickpeas and pumpkin seeds); Lutein and zeaxanthin (spinach, kale and broccoli, and eggs), fish and omega 3 — eating fish 3 times a week is
in total co-relation to cataract health and can lower the risk of cataracts; Supplements (it's preferable to get your nutrients from food, but it's not always possible) such as bilberry which is used traditionally to help protect against cataracts, glaucoma, and macular degeneration; Sun protection — make sure to wear eye protection whenever out
in the sun to help
reduce the risk of eye health issues; Lifestyle modifications — smoking and drinking are known health risks, but also for the eyes; and the possible upcoming Eye Drop intervention — drops containing Lanosterol have been tested on 3 dogs that cleared their vision after 6 weeks of using these drops — unfortunately, it's not yet available for human use at this time.
Zinc and selenium deficient diets are associated with increased inflammatory cytokines
in the skin and
reduce epidermal barrier function which predisposes one to developing eczema and other skin disorders.
Zinc has also been linked to massively
reduced acne
in plenty of studies.
This could be because frequent ejaculation leads to
reduced testosterone levels
in the long - run (no scientific evidence here, just speculating), likely due to
reduced zinc levels (about 5 mg of
zinc, a third of your body's RDA, is lost during ejaculation).