Sentences with phrase «inactivate tumor suppressor genes»
Additionally, alterations of subcellular localization through aberrant splicing or genetic mutations also provide ways to inactivate tumor suppressor genes (50).
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Working with colleagues at St. Vincent's Hospital in Sydney, Martin identified two individuals who had the characteristics of hereditary nonpolyposis colorectal cancer, which is usually caused by a mutation that inactivates one of a person's two copies of the tumor suppressor gene MLH1, but who showed no signs of mutation.
Up to 90 % of colorectal tumors contain inactivating mutations in a tumor suppressor gene called adenomatous polyposis coli (Apc).
Poor repair of these «double - strand breaks» can activate cancer - causing genes or inactivate tumor - suppressor genes.
p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma.
Because DDX3 exhibits tumor suppressor functions, such as a growth - suppressive property and transcriptional activation of the p21waf1 / cip1 promoter, and is inactivated through down - regulation of gene expression or alteration of subcellular localization in tumor cells, all these features together suggest that DDX3 might be a candidate tumor suppressor.
According to the two - hit theory of carcinogenesis by Knudson (Knudson 1971), a tumor suppressor is characterized by both copies of the gene being inactivated genetically, thereby eliminating its growth inhibition.
These suppressor genes are inactivated in tumors, and since cancer drugs work by reducing the activity of enzymes, they won't work on such suppressors because a drug can't inhibit a gene that is already inactivated.»
These rearrangements involved PGBD5 - specific signal (PSS) sequences at their breakpoints and recurrently inactivated tumor - suppressor genes.
These observations support the notion that BECN1 is a haploid - insufficient tumor suppressor gene and distinguish it from other classic tumor suppressors that require both alleles be inactivated in promoting tumorigenesis.
BRCA1 is a classical tumor suppressor and it is inactivated only when both gene copies / alleles are mutated (one by germ - line mutation and the other by somatic mutation).