Sentences with phrase «inactivated gene copy»

She harbors two mutant copies of a gene, and therefore lacks a protein that manages blood clotting, but researchers found that people with one inactivated gene copy outlive their peers by a decade and gain protection against diabetes.

Not exact matches

This vaccine would include a circular plasmid of DNA with the genes of specific proteins of the Zika virus inserted into it, and its effect will be similar to that of an inactivated vaccine — making the virus unable to copy itself.

The two studies together suggest that single copies of inactivating ANGPTL3 mutations are found in roughly one of every 250 people of European descent, whereas people with mutations in both copies of the gene — as in the family studied by Musunuru and colleagues — are much rarer.

Women tend to be protected from diseases related to genes on the X because female cells randomly inactivate one of the X chromosomes, and that leaves some cells with a normal copy up and running.

Working with colleagues at St. Vincent's Hospital in Sydney, Martin identified two individuals who had the characteristics of hereditary nonpolyposis colorectal cancer, which is usually caused by a mutation that inactivates one of a person's two copies of the tumor suppressor gene MLH1, but who showed no signs of mutation.

And because mouse embryo cells with inactivated copies of BRCA2 are more sensitive to ionizing radiation than normal cells are, «it's a reasonable extrapolation» that breast cancers with mutated copies of the gene may be especially good candidates for radiation therapy.

In Angelman's syndrome a child receives two copies of genes on chromosome 15 from his or her father, and a single inactivated copy of those genes from his or her mother.

Researchers found that the gene XIST, which is responsible for inactivating one of the two copies of the X chromosome in cells that store genetic material, works overtime in female patients with mental illnesses, such as bipolar disorder, major depression and schizophrenia.

The end result, Bier says, is that both copies of a gene could be inactivated «in a single shot.»

Two groups have recently improved upon the CRISPR - Cas9 technique, using it to cut and inactivate only the damaged copy of the gene.

According to the two - hit theory of carcinogenesis by Knudson (Knudson 1971), a tumor suppressor is characterized by both copies of the gene being inactivated genetically, thereby eliminating its growth inhibition.

BRCA1 is a classical tumor suppressor and it is inactivated only when both gene copies / alleles are mutated (one by germ - line mutation and the other by somatic mutation).