Sentences with phrase «include islet amyloid»
Other factors that adversely affect β - cell numbers and function include islet amyloid deposition (24), glucose toxicity (25), pancreatitis (8), and certain dietary influences (26).
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(A) Isolated islets from 3 - wk - old, female, Tg - hIAPP mice were cultured in presence of different concentrations of IAPP aggregates prepared in vitro from synthetic IAPP, as well as controls treated with other amyloidogenic proteins, including the Alzheimer's disease — associated protein Tau (the K18 fragment) and the bacterial amyloid Mcc.
12 - mo - old Tg mice displayed extensive islet pathology and overt signs of T2D, including massive amyloid deposits, impaired insulin production (Fig. 1) and severe hyperglycemia (> 360 mg / dl fasting blood glucose).