Sentences with phrase «includes measures of uncertainty»

Also, the model - based approach includes measures of uncertainty about our population estimates, which are not usually provided by more common approaches and are crucial for understanding the level of confidence we have about our estimates.»

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Based on the above conclusions, they consider that the future integrity of the property is highly at risk, taking into account the possible prospect of offshore oil exploitation, the uncertainty about the impact of invasive species, the already existing threats for which progress on the corrective measures is unclear and the globally increasing effects of climate change to coral reef systems, including the Belize Barrier Reef system.

A comprehensive risk assessment would determine flood hazard for individual structures by modeling watershed and floodplain characteristics at fine spatial scales; it would describe the varying levels of protection offered by all elements of a flood protection system and mitigation measures; and it would account explicitly for uncertainties, including those related to current and future flood hazard, structure value and vulnerability, and the current and future performance of flood protection measures.

Instead, they discuss new ways of playing around with the aerosol judge factor needed to explain why 20th - century warming is about half of the warming expected for increased in GHGs; and then expand their list of fudge factors to include smaller volcanos, stratospheric water vapor (published with no estimate of uncertainty for the predicted change in Ts), transfer of heat to the deeper ocean (where changes in heat content are hard to accurately measure), etc..

3.3.2 In practice, there are many possible sources of uncertainty in a measurement, including: a) incomplete definition of the measurand; b) imperfect reaIization of the definition of the measurand; c) nonrepresentative sampling — the sample measured may not represent the defined measurand; d) inadequate knowledge of the effects of environmental conditions on the measurement or imperfect measurement of environmental conditions; e) personal bias in reading analogue instruments; f) finite instrument resolution or discrimination threshold; g) inexact values of measurement standards and reference materials; h) inexact values of constants and other parameters obtained from external

These issues, which are either not recognized at all in the assessments or are understated, include: - the identification of a warm bias in nighttime minimum temperatures - poor siting of the instrumentation to measure temperatures - the influence of trends in surface air water vapor content on temperature trends - the quantification of uncertainties in the homogenization of surface temperature data, and the influence of land use / land cover change on surface temperature trends.

These findings are not sensitive to a wide range of assumptions, including the time series used to measure temperature, the omission of black carbon and stratospheric water vapor, and uncertainty about anthropogenic sulfur emissions and its effect on radiative forcing (SI Appendix: Sections 2.4 — 7).

In fact, on Oct. 22, Morningstar raised its uncertainty ratings, which measure the margin of safety around the fair value of a stock, to high from medium for a number of companies in the retail REIT universe, including Kimco Realty Corp., Macerich Co. and PREIT, citing possible losses in revenue because of consumer spending and the financing environment.