Sentences with phrase «including apoptosis»

Studies have established that CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion and migration.

Blocking the mechanisms involved in other methods of cell death including apoptosis and phagocytosis did not disrupt the process, confirming that entosis operates in a different way.

Members of a family that includes the apoptosis regulator APAF1 (apoptotic - protease - activating factor 1), mammalian NOD - LRR proteins (also known as NACHT - LRR proteins or CATERPILLERs) and plant disease - resistance gene products.

Not exact matches

This process includes the removal of the milk - producing epithelial cells, whereby the alveolar epithelium undergoes apoptosis and is replaced with adipocytes.

MAPK regulates cell functions, including proliferation, gene expression, differentiation, cell division and a form of cell suicide known as apoptosis.

Hypermethylation of DNA is a key epigenetic mechanism for the silencing of many genes, including those for cell cycle regulation, receptors, DNA repair, and apoptosis (5, 6, 7, 8).

There are currently 25 research groups in our school and areas of research in Biochemistry include membrane proteins, enzymology, folic acid biochemistry, structural biology, tRNA biology, neurochemistry, neurodegeneration, metabolism, systems biology, cancer biology, molecular parasitology, apoptosis and drug discovery.

These generic responses define intermediate phenotypes that comprise to varying extents all basic pathobiologies and include inflammation, thrombosis and hemorrhage, fibrosis, the immune response, proliferation, and apoptosis / necrosis (Figure 1).

We are actively engaged in advancing novel methods to image molecular events in both humans and animal models that include receptor expression, proliferation, angiogenesis, and apoptosis.

Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8 % O2 for 3 h) including several known hypoxia inducible genes such as MAP kinase phosphatase - 1 (MKP - 1), several HIF - 1 target genes including VEGF and GLUT - 1, genes implicated in apoptosis, signal transduction molecules, and transcription factors.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

Thousands of genes in fibroblasts and mouse macrophages, including those involved in inflammation, metabolism, apoptosis, growth, and differentiation are affected.

GAPDH participates in nuclear events including transcription, binding RNA, RNA transportation, DNA replication, DNA repair and apoptosis.

Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), are known to be vulnerable to apoptosis upon various technical manipulation, such as single cell dissociation, freezing and thawing, etc., which hinder their use for clonal isolation in gene transfer, differentiation and FACS cell sorting.

Apoptosis following inhibition of mTOR expression or function was associated with down - regulation of antiapoptotic proteins, including c - FLIP, MCL - 1, and BCL - 2.

These include T - cell depletion by apoptosis; anergy (ie, the process by which T cells that are presented with a peptide in the absence of costimulatory signals become refractory to further stimulation with the antigen and are therefore inactivated); and the development of regulatory T cells, which can actively suppress antigen - specific responses following re-challenge with the antigen.

Flow cytometry is an evolving field with a wide range of applications that includes immunophenotyping, cell division and apoptosis, cell activation, intracellular pH shifts, phagocytosis, oxidative burst and much more.

Independent of MMP activity, TIMP - 1 can promote growth and inhibit apoptosis through various pathways, including P13K and PKA [9] and, furthermore, TIMP - 1 is able to provide β cell - specific pro-survival effects [5, 6, 10].

They include its effects on endothelial cell «differentiation» to yield tubular - like structures, endothelial and tumor cell proliferation, apoptosis, and migration, as well as its effects on extracellular matrix remodelling enzyme activities of matrix metalloproteinase - 2 (MMP - 2) and urokinase - type plasminogen activator (uPA).

DAXX associates with RelB, a transcription factor of the NF - κB family that directly controls the expression of numerous apoptosis - and autophagy - relevant genes, including tumor suppressor protein kinases DAPK1 / 3 [1; 2].

It has been shown that the MAP kinases including JNKs, ERKs, and p38 phosphorylate p53 in response to different stressful stimuli, and in turn, activate a p53 response leading to cell cycle arrest and apoptosis [24].

In response to DNA damage, the checkpoint regulates and coordinates many cellular processes critical for genomic stability, including cell cycle progression, DNA repair, DNA replication, and apoptosis.

Other flow cytometry applications include: cellular phenotyping by multiparameter cytofluorimetric analysis, sorting of fluorescence protein - tagged cells, assessing apoptosis and cell cycle status, the identification / isolation of stem and cancer stem cells (e.g., marker positive, side - population, etc.) and the deposition of single cells.

We are investigating the potential role of RNase L in prostate cancer by focusing on basic cellular processes regulated by RNase L including autophagy and apoptosis.

These mutations are also relevant to melanoma and to numerous associated birth defects of organs including the ear, eye, brain, reproductive, digestive and respiratory tracts, hemophilia, and cellular defects in protein transport, organelle biogenesis and apoptosis.

Fluorescence - based assays Fluorescent markers such as EGFP, YFP, mCherry and mTomato or fluorescent biosensors can be used to measure a variety of real - time cell - based activities, including, intracellular transport, protein signaling, receptor desensitization, migration, division, apoptosis, metabolism, differentiation, chemotaxis, transcription and translation.

The regression equation for correlation between pSTAT5 and apoptosis was configured to include lesion size (total number of cells in the lesion) along with pSTAT5 % as potential predictive factors of apoptosis, and only pertains to lesions from a single mouse (red).

Because Wnt signaling is involved in the regulation of proliferation and apoptosis, and miR - 150 is reported to regulate proliferation of breast cancer cells, we think that the functions of these microRNAs include the regulation of cell proliferation and apoptosis.

All CM members have research interests in basic cancer mechanisms, including the normal functions of oncogenes and tumor suppressor genes; regulators of cell cycle and apoptosis; regulators of angiogenesis and metastasis; and stem cells and blood formation.

Shiitakes, of course, contain many of the superpower health benefits of mushrooms, including reducing cholesterol levels, helping maintain healthy weight levels, boosting immunity, and even helping to fight cancer by inducing a cell cleansing process called apoptosis.

[10] Methyl jasmonate, a plant stress hormone produced by many plants including rosemary, olive, and ginger, inhibits HK, triggering apoptosis in cancer cells.

Studies to date have demonstrated that phytochemicals in common fruit and vegetables can have complementary and overlapping mechanisms of action, including modulation of detoxification enzymes, scavenging of oxidative agents, stimulation of the immune system, regulation of gene expression in cell proliferation and apoptosis, hormone metabolism, and antibacterial and antiviral effects (15, 16).

RemedyLink Ellagic Acid contains a blend of USP grade ellagic acid and specific herbs which offer many health benefits, some of which include inhibiting fungi and yeast growth, killing bacteria, promoting the apoptosis of certain cells, and more.

Included in those is disrupting cancer cell replication, targeting and disrupting cancer stem cell development, and promoting cancer cell apoptosis (cell destruction)(6).

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

Several other fascinating research studies on the healing properties of lemons and limes have shown that cell cycles — including the decision a cell makes about whether to divide (called mitosis) or die (apoptosis — are altered by lime juice, as are the activities of special immune cells called monocytes.