Sentences with phrase «including biomarker»

Lipotype offers high quality lipid analysis services with its Lipotype Shotgun Lipidomics Technology for a wide range of customers and applications including biomarker identification for clinical researchers, pharma and biotech companies, functional food development for the food industry, claim support for the cosmetics industry, as well as for the small - scale profiling needs of academic researchers.

His primary clinical and research focus is dementia, with specific areas of interest including biomarkers to assist in the diagnosis and understanding of disease mechanisms for Alzheimer's and Parkinson's disease, and translational research using novel therapeutic approaches.

«GECCO aims to continue to discover additional colorectal cancer - related variants by investigating how genetic variants are modified by other environmental and lifestyle risk factors, including biomarkers as well as how they influence patient treatment response and survival,» Peters said, emphasizing how much further research is required to uncover the specific mechanisms by which genes modulate the intake of certain foods on colorectal cancer risk.

Professional clinical and research interests include biomarkers of cancer and chemotherapy toxicity, novel chemotherapy drugs and treatments, and more recently inhalant chemotherapy and exhaled breath condensate evaluate in the monitoring and treatment of primary and metastatic lung cancer.

Not exact matches

Studies — including at least one clinical trial with 100 participants — have found that this diet can significantly alter signs of disease, reduce weight and body fat, lower blood pressure, decrease levels of biomarkers associated with cancer, and improve blood - sugar levels.

The money raised benefits the Women's Cancer Programs of the Entertainment Industry Foundation (EIF) which include Lee Laboratories, the EIF Breast Cancer Biomarker Discovery Project and Cancer Support Communities.

Next steps include establishing robust biomarkers of human aging and examining the effects of calorie restriction in conjunction with antioxidant foods or substances like resveratrol, which mimic calorie restriction.

For researchers using mouse models to study a variety of cancers, including lymphoma, melanoma, breast, and prostate cancers as well as autoimmune and infectious diseases, the panel facilitates a highly sensitive and high - throughput investigation of biomarkers associated with disease progression.

Agnew, 28, has done her Ph.D. work with a team of researchers — including Caltech chemistry professor James Heath — to help them develop synthetic antibodies called «protein capture agents,» which can identify, bind to and remove protein biomarkers that are indicators of disease and infection.

This includes determining whether the drugs should be used earlier on in cancer treatment, finding biomarkers to predict response, and combining immunotherapy with other treatments.

Mochly - Rosen and colleagues identified several other potential biomarkers that were elevated in HD model mice, including the levels of 8 - hydroxy - deoxy - guanosine, a product of oxidative DNA damage, in the urine and the presence of mutant huntingtin aggregates and oxidative damage in muscle and skin cells.

Due to the increasing interest in digital health care systems, she moved to Roche's oncology department, where her activities included formulating and implementing validated assays, coupled with digital solutions and key contributions to the Discovery Biomarker portfolio and to the development of software tools for data mining purposes.

While the study included a large number of vascular risk factors, no information was available on individual biomarkers, or migraine specifics such as the presence or absence of migraine aura.

The authors anticipate that health care providers will use the early - detection biomarkers to test for their presence and levels in blood from pancreatic cancer patients and blood drawn from individuals with a high risk of developing pancreatic cancer, including those who have a first - degree relative with pancreatic cancer, are genetically predisposed to the disease, or who had a sudden onset of diabetes after the age of 50.

«The Quanterix Simoa will accelerate the discovery of new biomarkers to identify TBI and the development of new treatments, including targeted medications and other therapies,» says Charles L. Marmar, MD, the Lucius Littauer professor and chairman of Psychiatry at NYU Langone and executive director of the Cohen Veterans Center.

The members of the initiative hope to improve early detection of cancer by making an impact in a variety of areas, including doing epidemiologic studies on risk factors, developing new and improved methods of diagnostic imaging, discovering and verifying new biomarkers as indicators of cancer, and developing new technologies to aid early detection.

The researchers announced results from human and animal studies that found biomarkers of harmful cardiac, pulmonary, and reproductive effects from exposure to alternative tobacco products — a growing market of constantly evolving products including electronic cigarettes, hookah, and smokeless tobacco like snuff and gutkha.

The study found no clear change in blood eosinophils with dupilumab therapy; however, other biomarkers decreased, including fractional exhaled nitric oxide, thymus and activation regulated chemokine, immunoglobulin E and eotaxin - 3, confirming the biologic activity of dupilumab.

«To further enhance the diagnostic power of this biomarker, we plan to expand it by including non-coding RNAs, proteins, metabolites and mutations associated with pancreatic cancer.

It also calls for «new funding for the National Institutes of Health (NIH) through a temporary «innovation fund,» which would give the agency an extra $ 8.75 billion over 5 years; $ 500 million per year would fund specific projects within NIH's 27 institutes, including research on biomarkers and precision medicine.

Participants are offered a battery of tests over time, including neuropsychological testing, MRI scans, DNA sequencing, and analysis of blood samples for biomarkers, such as those reflecting stress response.

In previous studies, the same group along with others had demonstrated that microRNAs (miRNAs) produced by eukaryotic cells and viruses are present in human blood in highly stable, cell - free forms and these so called circulating miRNAs can serve as non-invasive biomarkers for the early diagnosis of various diseases, including viral diseases.

[Visiting Google] this summer opened my eyes to what it would mean if, instead of thinking of biomarkers as something we measure in blood or in a brain scan, we also include things we can measure on a smartphone: your activity level, your sleep, your social activity, and your cognitive performance.

His main research focus and clinical interest is fluid biomarkers for central nervous system disorders including Alzheimer's disease, for which he has developed new diagnostic tests.

Published in the Neurobiology of Aging, the study, which focused on detecting changes in the white matter connections of the brain, offers tantalizing potential for the identification of biomarkers connected to the development of dementia, including Alzheimer's disease.

Their natural characteristics make them uniquely suited for research and clinical applications, including as biomarkers both for diseases and for intrinsic biological activity.

Even though a biomarker shared by schizophrenia and autism might not reveal anything specific to autism, he adds, it might highlight a neural process that is central to social cognition, and that might be altered in several conditions, including autism.

Researchers, including a team from Children's National Health System, have identified head circumference and head tilting reflex as two reliable biomarkers in the identification of autism spectrum disorders (ASD) in children that are between 9 and 12 months of age.

Researchers collected data from 751 surveys between 1980 and 2014 that included 4,372,000 adults whose data of diabetes was measured through their biomarkers in 146 out of 200 countries where this study was carried out.

«Given this proof - of - principle, it's our hope that molecular biomarkers will be included in future prospective clinical trials in metastatic colorectal cancer.»

Medical / physical outcome measures, or biomarkers, include a wide range of tools, from blood - based analyses to neurophysiological and neuroimaging methods such as eye - tracking because eye gaze abnormalities are a common feature of FXS.

A similar principle is used in the medical field to detect biomarkers for different kinds of health conditions, including cancer, by taking breath samples.

He and colleagues are examining myriad factors, including looking at financial and educational outcomes, and even if bullying or being victimized is associated with genetic biomarkers.

Therapies could include those targeting biomarkers or other detectable molecules associated with diseases.

«Our group, which includes more than 180 myeloma researchers worldwide, has updated the definition of multiple myeloma for diagnostic purposes to include validated biomarkers in addition to the current clinical symptoms used for diagnosis which include, elevated blood calcium levels, kidney failure, anemia and bone lesions,» said lead author S. Vincent Rajkumar, M.D. a hematologist at Mayo Clinic.

Clariom D Pico assays allow discovery of coding and noncoding genes, exons, and splicing events, including rare transcripts, expanding the potential for finding novel biomarkers missed by alternative techniques.

Policymaking committees should consider giving less weight to food industry - funded studies, and include mechanistic and animal studies as well as studies appraising the effect of added sugars on multiple CHD biomarkers and disease development,» the article concludes.

In addition, researchers will create a bio-repository that will include blood samples, including patient genetic material, to better understand the biomarkers or genetic factors impact on patient outcomes.

For the biomarker study, the Johns Hopkins scientists prospectively analyzed blood samples collected from 141 women with advanced breast cancer (cancer that had spread to other organs) who were beginning a new treatment at seven cancer centers in the U.S., including The Johns Hopkins Hospital.

Dr. Leiser has over 10 years of experience in drug discovery and applying translatable neurophysiological biomarkers in diverse drug discovery projects across CNS disorders including schizophrenia, Alzheimer's, depression, epilepsy.

In Europe, the legislation for marketing of medicinal products (MP) and IVDs including predictive biomarker - based assays (Companion Diagnostics, CDx) are not directly linked which is challenging for co-development.

UNISI provides expertise in the measurement of cell signalling proteins, such as cytokines, chemokines and inflammatory biomarkers in multiple samples (including serum, plasma and tissue culture supernatants), using a multiplex suspension array system or a flow cytometric bead assay.

His research interests include new therapies, predictive biomarkers, cancer survivorship, and quality of care.

Current applications include studies related to carbon sequestration, as well as the development of biomarkers for breast and brain cancer, neurological diseases, and diabetes and kidney diseases, among others.

The research ideas you develop at the workshop should: • Lead to the significant advancement of our understanding of sensor technologies suitable for liquid biopsy • Consider the practical challenges of low volume liquid usually taken for analysis and the inconsistency of sample preparation across point of care sites • Prioritise biomarkers with high specificity for cancer or even for multiple cancer types, including markers specific to cancers that will become aggressive as opposed to non-lethal disease

The application to monogenic diseases also encompasses numerous topics of basic research, including the definition of the pathological mechanisms, the identification of the biomarkers, etc...

In addition to her expert skill as a clinician, Dr. Frontera also has many research interests including identifying biomarkers and predictors of early brain injury and vasospasm / delayed cerebral ischemia after subarachnoid hemorrhage and their impact on outcome; determining the efficacy of therapeutic strategies and developing guidelines for the management of patients with intracranial hemorrhage; evaluating the cost, length of stay, quality of life, functional and cognitive outcomes in a broader population of intracranial hemorrhage patients; developing guidelines for the integration of palliative care into the intensive care unit setting; and evaluating the relationship of Zika virus infection, Guillain - Barre, and other neurologic disorders.

The third promising biomarker involves imaging of the inner retina, including vascular, nerve fiber and ganglion cell components.

FOCUS FOR BASIC AND CLINICAL RESEARCH Dr. De Vivo noted that there is a need to define outcome measures such as muscle strength and function; pulmonary function; quality of life; and surrogate biomarkers including blood cell SMN transcripts and protein.

Development of novel / customised Luminex bead arrays (MHRA): Luminex technology uses bead arrays for the quantitative detection of diverse biomarkers, including cytokines, antibodies, signalling molecules and proteases.