Sentences with phrase «including cell design»

Not exact matches

Due to the volume of product required, Aegg designed the bespoke automation and packaging solution for its client at the chosen manufacturing site, which included a dedicated manufacturing cell within an already established BRC Grade A facility.

Our materials make innovation design solutions possible in a range of industries including consumer electronics, solar and wind energy, fuel cells, package printing, aerospace, automotive, food safety and industrial applications.

Also called «sensory trails,» the broad, generally flat paths have been created to accommodate wheelchairs and guide animals, and can include specially designed ropes, rails, and Braille signage, as well as audio tours accessible by cell phones and other smart devices.

We designed chimeric antigen receptor (CAR) T cells that specifically target podoplanin (PDPN), a key protein for the progression of solid tumors, including GBM.»

And early stage startup Neochromosome, which includes Boeke, intends to raise money to design synthetic chromosomes for medicine that could be used in an off - the - shelf universal cell line in cell therapies and transplants with minimal risk of rejection from the immune system.

But the Hopkins group, which included force microscopist Jan Hoh, probed their cells with an AFM designed to work in reverse.

Designed by Harvard researcher Zachary Manchester, about half the wafer consists of a solar cell for generating electricity, and the rest includes a small microprocessor, a radio transceiver and magnetometer, and a gyroscope for navigation and orientation.

Saatchi, which is owned by France's Publicis Groupe, SA, chose LifeStraw over a field of competitors that included a reusable controller to improve the distribution of IV fluids, a collapsible wheel that can be folded down for easier storage when not in use on bicycles or wheelchairs, an energy - efficient laptop designed for children in developing countries, a 3 - D display that uses special optics and software to project a hologramlike image of patient anatomy for cancer treatment, an inkjet printing system for fabricating tissue scaffolds on which cells can be grown, a visual prosthesis for bypassing a diseased or damaged eye and sending signals directly to the brain, books with embedded sound tracks to help educate illiterate adults on health issues, a phone that provides telecommunications coverage to poor rural populations in developing countries, and a brain - computer interface designed to help paralyzed people communicate via neural signals.

We hope this leads to the ability to design, study and test new therapies for every patient on their own cells in the lab, leading to new treatments and breakthroughs in personalized medicine for individuals with a variety of lung diseases, including cystic fibrosis,» explained lead author Katherine McCauley, a PhD student at BUSM.

Proponents of intelligent design, for example, argue that some supreme being created the first cell four billion years ago with all of its complex biochemical systems complete, including those that were to be used later, say for blood clotting.

The discovery relies upon a «conjugated redox polymer» design with a naphthalene - bithiophene polymer, which has traditionally been used for applications including transistors and solar cells.

An appliance designed for use in a café or restaurant could include a bioreactor for growing a fresh cell compote to be added to a food product.

Last year, the International Synthetic and Systems Biology Summer School in Italy began offering researchers, at all levels, and industrial professionals 5 days of courses in topics including genome design, metabolic engineering, synthetic circuits and cells, biological design automation, and high - throughput techniques.

The causes of such unpredictable results, Harris said, can include bad ingredients in the lab, including contaminated and misidentified cell lines; poor research design, including insufficient numbers of mice in animal studies; statistical error and overreach, including «HARKing» (hypothesizing after the results are known), a push beyond the limits of the data; and funding pressures, which can lead scientists to hype or exaggerate their results to remain competitive for additional grant money.

The engineered cells contain an antibody - like protein known as a chimeric antigen receptor (CAR), which is designed to bind to a protein called CD19 found on the surface of B cells, including the cancerous B cells that characterize several types of leukemia.

The modified T cells contain a protein known as a chimeric antigen receptor (CAR), which is designed to target the CD19 protein found on the surface of B cells, including the cancerous B cells that characterize several types of leukemia and lymphoma.

Testing many variants, the team eventually found an artificial receptor design that worked well in cell culture, enabling host T cells to efficiently destroy cells producing antibodies to desmoglein, including those derived from PV patients.

To do this, Lu and a team including MIT postdocs Lior Nissim and Ming - Ru Wu, have built a gene circuit encoded in DNA designed to distinguish cancer cells from noncancer cells.

Once activated, the circuit expresses proteins designed to direct the immune system to target the tumor cells, including surface T cell engagers, which direct T cells to kill the cells.

Dr. Weston now leads a team of researchers in the design and implementation of high throughput, cell - based assays including high - content screening.

The human genome contains around 20,000 genes, by refining CRISPR - Cas9 technology and using it to screen the leukemia genome the team uncovered a catalogue of approximately 500 genes that are essential for cancer cell survival, including more than 200 genes for which drugs could be designed.

«To understand the factors behind T - cell - receptor binding to peptides will have major impact on biomedical developments, including vaccine design and immunotherapy.»

They are like natural proteins, including those that embed themselves in cell membranes, and can be designed to have very specific forms and functions.

Phenylalanine pairs capable of forming a molecular switch are also present in many other signaling proteins, including receptors in human cells, making it an attractive target for drug design and biotechnology applications.

In 2002, his group was the first to report the design of «second - generation» CARs that, in addition to a binding domain outside of the T cell and a signaling domain inside, included a costimulatory domain designed to promote cell proliferation and survival.

His research interests have included the immunogenetics of diabetes, the biology of tumour - associated antigens and cell adhesion molecules, and ethical aspects of the design of trials involving human subjects.

Paul Hudson is granted for his project «INTEGRATE: A new paradigm for designing and cell factories», which also includes Per - Olof Syren at KTH / SciLifeLab, Jens Nielsen at Chalmers / SciLifeLab, and partners in EPFL Switzerland and Griefswald Germany.

His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function, designing strategies to overcome tolerance and enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate vaccines.

Enriched by the rapid evolution of these technologies, TEFOR - TACGene has developed a solid expertise in the design, production and use of TALE - N and CRISPR / Cas9 systems, both for its own research projects in cultured cells and in collaboration, in many model organisms, including the rat, zebrafish, Drosophila, and Xenopus as part of the National Infrastructure in Biology and Health TEFOR supported by Investissement d'Avenir programme (2012 - 2019).

, several groups have designed modular toolkits to assist with tagging genomic loci in other model systems, including mammalian cells.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Prof. Su's current research fields include the design, the synthesis, the property study and the molecular engineering of nanostructures and highly organized and hierarchically self - assembled porous materials, bio-integrated living and bio-inspired materials including leaf - like materials by the immobilization of living organisms and biomaterials for catalysis, photocatalysis, CO2 reduction and water splitting, artificial photosynthesis, nanotechnology, biotechnology, information technology, energy storage and conversion, cell therapy and biomedical applications.

NEW YORK, June 1, 2016 — Cancer immunotherapy, which is designed to empower a patient's own immune system to eliminate cancer cells anywhere in the body, has produced remissions in very advanced cancers, including former U.S. president Jimmy Carter in 2015.

Here we describe the idea, its potential utility, early proofs - of - concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.

A novel approach to cancer immunotherapy — strategies designed to induce the immune system to attack cancer cells — may provide a new and cost - effective weapon against some of the most deadly tumors, including ovarian cancer and mesothelioma.

We designed our strategy to select against re-targeting the «knockout - first» allele and identify essential genes in ES cells, including the histone methyltransferase Setdb1.

Specifically, we have generated clusters of transcripts that behave the same way under the entire spectrum of the sixty - seven experimental conditions; we have assembled genes in groups according to their time of expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic resources.

This website is designed with easy to use features; that includes creation of audio greetings using cell phones instead of switching computer every time.

They have plenty to share about the film, including lots of details about the thought process behind the designs and concepts in the film, as well as small details they find particularly interesting (like the inclusion of modern things like cell phones and social networking.)

Past assignments have included creating public - service announcements on energy efficiency for local broadcasts, raising awareness of the dangers of cell phone use while driving, and designing playground equipment for preschool children.

This bundle includes the following Task Cards: 12 Google Slides Task Cards: • Inserting slides • Changing slide background color • Adding a slide theme / design • Inserting images • Inserting Shapes • Inserting Word Art • Adding slide transition • Adding object animation • Creating Tables • Shading Tables • Downloading files to Microsoft PowerPoint from Google Slides • Uploading Microsoft PowerPoint documents into Google Slides 20 Google Sheets Task Cards: • Inserting columns • Deleting columns • Deleting rows • Inserting rows • Adding currency • Removing currency • Adding decimal places • Removing decimal places • Adding borders • Changing border color • Adding fill color • Sorting data • Merging cells • Unmerging cells • Creating charts • Customizing Pie Charts — A closer look • Moving charts to new sheets • Changing Chart types • Adding New Sheets • Deleting sheets 12 Google Drawings Task Cards: • Creating Tables • Shading tables • Insert Image • Insert Shape • Shape Fill • Line Thickness • Line Style • Line Color • Sending shapes to back • Bringing Shapes to Front • Rotating Shapes • Changing Shapes 12 Google Docs Task Cards: • Creating Tables • Inserting Page Numbers • Inserting images • Formatting Text (Bold, Italic, Underline) • Shading tables • Word count • Line Spacing • Text Alignment • Inserting Bullet Points • Inserting Numbered Lists • Downloading files to Microsoft Word • Uploading Microsoft Word documents into Google Docs

You will be able to quickly design an eye catching bulletin board display featuring your students» work using the bulletin board banner and additional cell phone accent pieces that are included with this set of Back to School English teaching resources.

Design cues that distinguish the GLC F - Cell from a standard GLC crossover include blue accents on the grille, alloy wheels, side skirts, and rear bumper.

Design features include Smart's signature Tridion cell — the exposed metal frame to which its composite plastic body panels are attached.

The Honda Clarity series was recognized by Edmunds» editors for its leading - edge approach to electrified powertrain technology: «With options including pure electric, plug - in hybrid and hydrogen fuel cell models, the 2018 Honda Clarity provides unmatched flexibility when it comes to alternative fuel choices, and proves that innovative design can push the industry further toward a future using renewable energy.»

Mercedes - Benz says the R 015 was also designed to accept its hydrogen fuel - cell system, which includes a high - voltage battery pack and CFRP - constructed impact - protected pressure tank.

Honda Clarity Series As the next progression of Honda's dynamic styling for electrified products, the Clarity series, Clarity Plug - in Hybrid, Clarity Fuel Cell and Clarity Electric, has a low, wide aerodynamic body with unique design elements, including its own special hero color, and differentiated front styling, headlights, tail lamps, non-compromised trunk space, Honda Sensing standard and 18 - inch alloy wheel designs.

For the rest of us, Hyundai did a good job at Geneva with a wide range of offerings, from the Le Fil Rouge concept that showcases the company's next design language, through the Santa Fe midsize SUV — which may have the industry's best array of standard safety features, including blind spot detection — through extensions of the line such as the electric Kona and Nexo second - generation fuel cell vehicle.

Every possible toy is included in the strikingly low $ 69,050 price tag including (take a breath) automatic shades for the rear side windows and rear window, auto hold, a 360 degree camera, Bluetooth, a wireless charging pad located in a compartment designed specifically for cell phones, driver alert detection, radar cruise control with lane departure warning and lane keep assist, rear cross-traffic alert, a large 12.3» screen to compliment said Audi MMI knob, a HUD, traction control, automatic braking with pedestrian detection, and even parking sensors.

The updates include a especially designed turbocharger, a new sports exhaust system with a 100 - cell sports cat with Y - pipe, a high - pressure fuel pump, a pre-feed fuel pump, a sportive suction system and a special water pump to keep things cool.