Sentences with phrase «including change in treatment»

Individualized actions were taken in 23 of the 91 (25 percent) based on clinical sequencing findings, including change in treatment for 14 patients (15 percent) and genetic counseling for 9 patients (10 percent).

This 78 - page reference, recently updated to include changes in the treatment of digital rights, contains in - depth explanations of virtually every clause in traditional publishing agreements, along with helpful negotiation tips and strategies.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Both bills provide for similar changes in the corporate and international tax code but differ mostly in the structure of the individual tax code, including the tax treatment of pass - through businesses and individual income tax brackets as well as the status of the estate tax.

The winds of reaction and change were evident in publications of the 1970s and 1980s, which included two fill - length treatments of Israelite history: J. A. Soggin's A History of Ancient Israel (1984) and J. Maxwell Miller and John H. Hayes's A History of Ancient Israel and Judah (1986).

After 12 days in intensive care I was moved to a ward and still needed lots of treatment including physiotherapy to learn to breathe unassisted and walk again, dressing changes for the wound on my tummy, dialysis treatments and blood transfusions.

Some treatments of this occurrence include baby massage, upright feeding, change in diet formula, gripe water and more.

Question topics during a post-announcement Q&A included the surprise resignation of Joe Percoco, the extensive list released today of New York endorsers of Hillary Clinton and Mayor Bill de Blasio's absence from that list, whether he supports de Blasio's call for changes to bail in light of the killing of Police Officer Randolph Holder, «felony drug dealers» being offered treatment instead of jail time, dealing with homeless people in the subway and rail systems, details of his executive order extending anti-discrimination laws to transgender people, Board of Regents Chancellor Merryl Tisch's departure and rules and laws around criminal defendant drug diversion programs.

To halt this trend, Governor Cuomo has implemented aggressive efforts, including changes in insurance to ensure coverage of substance use disorder treatment, increased access to treatment, additional treatment capacity in regions across the state, and comprehensive public awareness efforts.

Democrats have been trying to make these changes — which include giving judges more authority in sentencing by repealing the minimums, and developing treatment programs to replace incarceration for new offenders — for years now, but have been stopped in the past by Republicans controlling the State Senate.

With his «Changing Lives» motto, President Mahama, will in the coming days, commission other major projects in Accra, including the new Ridge Hospital, inauguration of the James Town - Bukom ultra modern boxing arena, inaugurate the new liquid waste treatment plant, to make way for the eternal closure of lavender hill, which has been in existence for the past 60 years.

These include a directive in 2014 that insurers cover gender reassignment surgery, hormone therapy and other gender transition treatments, and a 2016 change in Medicaid to include coverage for these services to minors.

In a study that included children and young adults with relapsed or refractory cancer, incorporation of integrative clinical genomic sequencing data into clinical management was feasible, revealed potentially actionable findings in nearly half of the patients, and was associated with change in treatment and family genetics counseling for a small proportion of patients, according to a study in the September 1 issue of JAMIn a study that included children and young adults with relapsed or refractory cancer, incorporation of integrative clinical genomic sequencing data into clinical management was feasible, revealed potentially actionable findings in nearly half of the patients, and was associated with change in treatment and family genetics counseling for a small proportion of patients, according to a study in the September 1 issue of JAMin nearly half of the patients, and was associated with change in treatment and family genetics counseling for a small proportion of patients, according to a study in the September 1 issue of JAMin treatment and family genetics counseling for a small proportion of patients, according to a study in the September 1 issue of JAMin the September 1 issue of JAMA.

Examples include changing policies to encourage older adults to remain part of the workforce for longer (e.g., removing tax disincentives to work past retirement age), emphasising low - cost disease prevention and early detection rather than treatment (eg, reducing salt intake and increasing uptake of vaccines), making better use of technology (eg, mobile clinics for rural populations), and training health - care staff in the management of multiple chronic conditions.

«Surprisingly, we saw PSA reductions in all of 10 men, including four whose PSA didn't change during the trial, who were given testosterone - blocking drugs after the testosterone treatment,» says Denmeade.

Hepatic encephalopathy occurs when the liver can not remove certain toxins and chemicals, such as ammonia, from the blood.1 These toxins and chemicals then build up and enter the brain.1 Hepatic encephalopathy is one of the major complications of cirrhosis (scarring of the liver), and a leading cause of hospital re-admission due to its recurrence, despite treatment.1 It can occur suddenly in people with acute liver failure, but is seen more often in those with chronic liver disease.1 Symptoms of hepatic encephalopathy include mild confusion, forgetfulness, poor concentration and personality or mood changes, but can progress to extreme anxiety, seizures, severe confusion, jumbled and slurred speech and slow movement.1 The first step in treatment is to identify and treat any factors that cause hepatic encephalopathy.2 Once the episode has resolved, further treatment aims to reduce the production and absorption of toxins, such as ammonia.1 Generally, there are two types of medication used to reduce the likelihood of another hepatic encephalopathy episode — lactulose and rifaximin.2 However, it remains a leading cause of hospitalisations and re-hospitalisations in cirrhotic patients, despite the use of the above - mentioned standard of care treatment.

«The totality of evidence clearly indicates that the more widespread and appropriate utilization of statins, as adjuncts, not alternatives to therapeutic lifestyle changes, will yield net benefits in the treatment and primary prevention of heart attacks and strokes, including among high, medium and low risk patients unwilling or unable to adopt therapeutic lifestyle changes,» said Hennekens.

«A significant part of adulthood is managing health care, which includes regular trips to the doctor, following treatment plans, and being aware of symptoms and changes in health,» said Nancy Cheak - Zamora, an assistant professor in the MU School of Health Professions and researcher in the Thompson Center for Autism and Neurodevelopmental Disorders.

They have called attention to more or less «evenly distributed errors» across Lomborgs treatment of population, food, forests, air pollution, acid rain, climate change, and biodiversity loss, among other topics errors including all of the types I identified in his energy chapter, and more even while acknowledging, as I did, that in this potpourri Lomborg manages to get a few things right.

Clinicians and researchers will work together to evaluate possible treatment opportunities based on this insight, including whether supplementing copper in the diet could change risk for those who carry the mutation.

Improving the understanding of these genetic changes in these diseases, can point to new directions for diagnosis and treatment, including a way to potentially differentiate aggressive tumors from those that are not life threatening.

«I think that those lifestyle changes, coupled with treatments that are being developed in the lab, will enable us to forestall or even prevent a whole host of conditions that all of us now dread — including Alzheimer's, cancer, Parkinson's and Type 2 diabetes.»

Additional limitations to the traditional approach include: costly failures to replicate positive results in larger trials; difficulty in determining the reasons for negative results; low yield in terms of identifying disease or intervention mechanisms due to an exclusive focus on symptom change and clinical endpoints; and, the expensive and very lengthy practice of first establishing multi-component psychosocial treatments followed by years of «unpacking» studies.

This year's Action Award honorees include global leaders in the fight to end cancer as we know it; a world leader in advancing the emerging field of regenerative medicine and game - changing cell therapy medical treatments; the president of a non-profit group focused on developing cures for chronic, debilitating and fatal diseases; a sickle cell and stem cell advocate and founder / science administrator of the Axis Advocacy; and the founding director of the Institute for Integrated Cell - Material Sciences (iCeMS) at Japan's Kyoto University.

The changes included reductions in the use and dose of radiation therapy and chemotherapy drugs called anthracyclines for treatment of acute lymphoblastic leukemia (ALL), Hodgkin lymphoma and Wilms tumor, a cancer of the kidneys.

Guided by a world - renowned Scientific Advisory Council that includes three Nobel laureates and 26 members of the National Academy of Sciences, CRI has invested $ 336 million in support of research conducted by immunologists and tumor immunologists at the world's leading medical centers and universities, and has contributed to many of the key scientific advances that demonstrate the potential for immunotherapy to change the face of cancer treatment.

A gene screen revealed a number of genetic changes in the first (daughter) and third (great granddaughter) high - fat mice generations, including several linked to increased breast cancer in women, increased resistance to treatment, poor prognosis, and impaired anticancer immunity.

The cellulite treatments that seem to be the most effective are simpler, natural techniques like massage (especially cupping massage), dry brushing, and dietary changes (like including more fat soluble vitamins and gelatin - rich foods in your diet).

In addition to diet and lifestyle changes, natural therapies including botanical medicine, clinical nutrition, hydrotherapy, homeopathy, naturopathic manipulation and traditional Chinese medicine / acupuncture, may also be used during treatments.

Founded in 1897, PTA has been a leading voice in policy decisions that have forever changed the lives of America's children, including the passage of child labor laws, ensuring hot and nutritious lunches in schools, improvements to the unfair and punitive treatment of children in the justice system, and increased education opportunities for all children.

Cosmetic changes include RACE branding decals in Red & green combination, New Maze Grey body color, Front Caliper in Golder color, Red rims on the front and Rear, Rear Shock absorber spring gets red treatment and Black rubber mat with red elements avaialble as accessory.

Newly updated to include recent changes in the treatment of digital rights, the Model Contract examines publishing contracts clause by clause, empowering authors with knowledge and insight for their negotiations with their publishers.

Newly updated to include recent changes in the treatment of digital rights, the Model Contract examines publishing contracts clause - by - clause, empowering authors with knowledge and insight for their negotiations with their publishers.

This includes changes of typeface, type size, image treatments, and the overall style in which your book was formatted.

Please note, in keeping with the wishes of the Texas Board of Veterinary Medical Examiners, Dr. Hines» services will not include «specific diagnosis, treatment, correction, change, manipulation, relief, or prevention of animal disease, deformity, defect, injury, or other physical condition, nor the prescription or administration of a drug, biologic, anesthetic, apparatus, or other therapeutic or diagnostic substance or technique or the ability or willingness to do so».

This treatment will include changes in your pet's normal diet.

«There are a number of alternative canine leukemia treatment options available, in many different disciplines including herbal supplements, acupuncture, acupressure and dietary change.

Treatments include a change to a soft, bland diet and, in severe cases, surgery.

Integrative treatments may include herbal therapy and acupuncture in addition to antioxidants and diet changes.

Treatment of diabetes includes the injection of insulin and changes in diet.

Your vet can offer a variety of treatments depending on the severity of the condition, but may include lifestyle changes, anti-inflammatory medications, or, in extreme cases, surgery.

Some of the valuable information our veterinary team will discuss with you includes: signs, symptoms, and treatment of arthritis, nutritional differences in seniors, how to keep your senior active and healthy, and what changes you can expect as your pet ages.

Treatment includes both medication and simple changes in your home to allow your cat to maintain their normal behaviors.

Observable changes in cats after successful treatment may include weight gain, better hair coat and grooming habits, normal appetite, an absence of vomiting, and a greater tendency to «cat nap» during the day and sleep at night.

The Club Oasis in Grand Hyatt Mumbai features a spa center all equipped with the facilities like private treatment suites, each with its own private shower and changing area, steam and sauna rooms, whirlpool bath and two outdoor pools, including a children's pool with a poolside bar and sun deck.

There is a seasonally changing menu of special offers that can be added to the room rate, including one that combines spa treatments, local guided tours, refreshments and parking in the hotel's private garage.

Each entry includes a Technical Summary, which discusses the materials and techniques used by the artists in the creation of the paintings, as well as any changes and documented treatments.

In models that include indirect effects, different treatments of the indirect effect are used, including changing the albedo of clouds according to an off - line calculation (e.g., Tett et al., 2002) and a fully interactive treatment of the effects of aerosols on clouds (e.g., Stott et al., 2006b).

Our financial regulatory advice to financial institutions has spanned a wide range of subjects, including the chartering of new banking institutions and their subsidiaries; charter conversions; conversions to BHC; FHC elections; the expansion of regulated banking and non-banking activities through acquisitions and de novo expansion; broker - dealer registration and material changes in business operations; the treatment of new financial products under regulatory capital requirements; and legal risks in cross-border payment and securities settlement systems.

Benchmark cases successfully litigated by Leopold and his firm include those that led to significant improvements in automotive safety, including safer child seatbelt restraint systems, SUV stability and handling, safer tires and to significant changes in the managed care industry that resulted in greater access to care and treatment for catastrophically ill children and adults.