Sentences with phrase «including endocannabinoids»

G - protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N - arachidonoylethanolamide (also called anandamide or AEA) and 2 - arachidonoylglycerol (2 - AG)(PubMed: 9888857, PubMed: 22388959).

He developed an innovative microdialysis approach that allows the in vivo sampling of lipid signaling molecules in the brain (including endocannabinoids) and has demonstrated that voluntary self - administration of ethanol, heroin, and cocaine produces distinct drug - and region - specific changes in brain endocannabinoid levels.

Not exact matches

The endocannabinoid system is located throughout the mammalian body, including the brain and all peripheral organs, and participates in the control of many physiological functions in the body, including food intake, energy balance, and reward.

The Vanderbilt scientists are pursuing other potential applications of activating endocannabinoids by substrate - selective COX - 2 inhibition, including relieving pain, treating movement disorders, and possibly preventing colon cancer.

His research program has provided innovative, seminal discoveries in the field of neuropharmacology, including characterization of the roles of endocannabinoids in the reinforcing effects of abused drugs and, more importantly, the involvement of dysregulated endocannabinoid function in the neuroplastic events that contribute to the pathology of addiction.

Platforms included: Lipid metabolism, Bile acids, Organic acids Central Carbon metabolism, Biogenic amines and amino acids, Acyl - carnitines, Eicosanoids, Endocannabinoids and oxidative stress markers.

Dr. Parsons has provided similar insights into the mechanisms through which endocannabinoids modulate the rewarding effects of opiates, alcohol, and cocaine, and he is presently extending his evaluations of this stage of the addiction cycle to include animal models of commonly occurring genetic polymorphisms that are associated with problematic drug use and dependence in humans.

What is particularly exciting about this research is that it opens up a whole new chemical system, called the endocannabinoid system, as a potential target for new avenues of research which could include illnesses like dementia.

The endocannabinoid system regulates energy homeostasis through G protein — coupled cannabinoid - 1 receptors5, 6 located in the central nervous system and in various peripheral tissues, including adipose tissue, muscle, the gastrointestinal tract, and the liver.7 While peripheral cannabinoid - 1 receptor activation decreases adiponectin production in adipocytes, 8 central cannabinoid - 1 receptor activation in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorders.

As you may know, the reason why cannabis medications work so efficiently is because our bodies are equipped with an endocannabinoid system, which includes a group of receptors that are configured only to accept cannabinoids.

Recent studies show that vigorous exercise stimulates the release of anandamide, and even exercise of moderate intensity activates the endocannabinoid system in the brain, inducing beneficial changes in mental status including analgesia, sedation, anxiolysis, and a sense of well - being.8 9

Research has proven the endocannabinoid system is involved in a number of physiological processes that can include appetite, pain, mood, and memory.

A well - operating endocannabinoid system is crucial to overall health and proper functioning in many processes, including energy balance and metabolic process.

The endocannabinoid system is responsible for maintaining balance within the body, including regulating the immune response, appetite, sleep, mood and more in all mammals.