Sentences with phrase «including epigenetic changes»

Not exact matches

This discrepancy suggests that other hereditary factors also play a role, such as epigenetic changes in the genetic material, including DNA methylation.

The genome - wide epigenetic changes clustered in certain chromatin domains and controlled «gene expression changes that specify different malignant traits, including the ability to form tumors,» McDonald said.

The researchers linked the excess weight and changes in metabolism to epigenetic modifications that reduce expression of the gene for adiponectin — a hormone that helps regulate several metabolic processes, including glucose regulation.

Several candidate mechanisms of CRCI have been proposed, including inflammation and cytokine dysregulation, chemotherapy - induced epigenetic changes, blood — brain barrier disruption, hormone deficiencies, oxidative DNA damage and shortened telomere length, and genetic susceptibility.21 — 26 However, the heterogeneity and design limitations within the emerging body of evidence have led to recommendations for harmonising study methodologies and moving towards multisite, longitudinal research.3 27 Such approaches would support the demonstration of robust relationships between measurable biological processes and cognitive outcomes.

Research evidence shows that maternal stressful experiences during pregnancy and in early postnatal period can lead to biological changes including neuroendocrine, epigenetic and neuroanatomical changes in children, 28 thereby increasing their risk for health and behavioural problems later in life.