Sentences with phrase «including fibroblasts»

Many different cell types including fibroblasts, smooth muscle cells, endothelial cells, and cancer cells exert traction forces on the fibrous components of the extracellular matrix.

These scientific goals guide our efforts at determining the role and mechanisms of the stromal cells, including the fibroblasts, endothelial and lymphatic elements, the matrix and the inflammatory / immune cells as critical targets for therapeutic intervention.

The team also tested nanoparticle absorption for other kinds of human cells, including fibroblasts from donors of older ages and found significant differences.

Rivolta and his colleagues knew that during embryonic development, a handful of proteins, including fibroblast growth factor (FGF) 3 and 10, are required for ears to form.

Not exact matches

The tissue, called the stroma, includes fat cells, or adipocytes, that provide padding; fibroblasts, which make the framework for tissue; pericytes in blood vessels, which are contractile cells that help regulate blood pressure; as well as myoepithelial cells comprising the outer layer of the ductal system through which milk flows.

The experiments, including studies conducted in a bioengineered 3 - D model of lung tissue seeded with relevant cells, showed that CHI3L1 regulates a pathway that recruits cells such as macrophages and fibroblasts that produce the scarring, or fibrosis.

«The most intriguing of these genes is FGFRL1, which has a cluster of amino acid substitutions unique to giraffe that are located in the part of the protein that binds fibroblast growth factors — a family of regulators involved in regulating many processes including embryo development,» Cavener said.

The key experiments included for replication were selected because they examine the induction of POSTN expression in the pulmonary stromal fibroblasts and test the role of POSTN in primary tumor formation and metastatic efficiency, which are relevant as the role of POSTN as a possible prognostic marker and target for anticancer therapies is explored (Xu et al., 2012; Nuzzo et al., 2014).

Xu and his team, which includes researchers from Penn's departments of Dermatology and Biology, as well as the New Jersey Institute of Technology, started with human skin cells called dermal fibroblasts.

Thousands of genes in fibroblasts and mouse macrophages, including those involved in inflammation, metabolism, apoptosis, growth, and differentiation are affected.

Mechanical properties of many different cell types including glial cells, platelets, cardiocytes, macrophages, endothelial cells, epithelial cells, fibroblasts, bladder cells and more have been determined using F - d spectroscopy.

We included human dermal fibroblasts (Fib) in these validation experiments in recognition of the overlapping marker profiles of pericytes and fibroblasts.

(6) Moreover, subcutaneous adipose of prematurely - aged transgenic mice exhibited high levels of staining for the senescence marker senescence - associated - β - galactosidase (SAβ - gal) and expressed high levels of several established markers of senescence, including p21, p19, interleukin - 6, (insulin - like growth factor binding protein - 2 (Igfbp2), and Pai - 1; primary BubR1H / H; INK - ATTAC mouse embryonic fibroblasts forced artificially into senescence by oncogenic Ras or serial passage exhibited a subpopulation that was both GFP + and stained positively SAβ - gal.

This approach has led to the finding that activated fibroblasts in the tumor stroma mediate immune suppression in several mouse models of cancer, including the autochthonous model of pancreatic ductal adenocarcinoma of the Tuveson lab.

Confocal images of sections of the seminiferous tubules illustrated the existence of various iPS cell - derived EGFP - positive cells, including flattened fibroblast cell - like myoid at the outermost layer of the tubules, spermatogonial stem cells with spherical nuclei closest to the basement membrane and spermatocytes with distinctive chromatin closer to the lumen than spermatogonial stem cells (Figure 6D).

«Fibroblasts are also abundant and integrally involved in many other tissues, including skin, breast, lung and some cancers.

- The other forms the lower dermis, including the reticular fibroblasts that synthesise the bulk of the fibrillar ECM, and the pre-adipocytes and adipocytes of the hypodermis.

The researchers then successfully prodded what they call keratinocyte - derived iPS cells or KiPS cells to distinguish them from fibroblast - derived iPS cells into becoming all the cell types in the human body, including heart muscle cells and dopamine - producing neurons, which are affected by Parkinson's disease.

UK Research teams, including the «Wellcome Trust Centre for Stem Cells Research» had worked to understand mechanisms that explain the remarkable functional diversity of the fibroblasts constituting the skin.

In mouse embryo fibroblasts (MEFs)[2], as well as in the PCa cell lines [unpublished data], DAXX represses expression of these genes via mechanisms that include its binding to DNA methyl transferases (DNMTases) and hypermethylation of the promoter regions of the corresponding genes [2].

To further facilitate genome editing in pigs, we report here establishment of a pig line with Cre - inducible Cas9 expression that allows a variety of ex vivo genome editing in fibroblast cells including single - and multigene modifications, chromosome rearrangements, and efficient in vivo genetic modifications.

Differentiation took place either in control culture media, or in the presence of various agents including retinoic acid (RA), Fibroblast Growth Factor - 2 (FGF2) and Wnt pathway activators.

· Cancer Growth and Spread — Healing Angiogenesis and Metastasis, discussing blood vessel development and growth factors, dysregulation including hypoxia and other blood supply stress responses in cancer and other diseases and how cancer cells travel and invade — metastasis via the complex tumour microenvironment — TME — comprised of immune cells, cytokines, growth factors, reactive oxygen species (ROS) and cancer - associated fibroblast (CAF);

The effects of therapeutic lasers in wound healing include vasodilation, angiogenesis, increased collagen synthesis by fibroblast, differentiation of fibroblast into myofibroblasts, stimulation of leukocytes, and enhanced antioxidant activity.

A continuous mode maximizes thermal effects; this mode is therefore primarily used for tissue heating before stretching.9 Pulsed modes produce decreased thermal effects but are used for other applications, including acceleration of the inflammatory process, increased fibroblast proliferation, and increasing the tensile strength of healing tissues.9

The list includes platelet - derived growth factors (PDGF), ß - thromboglobulin, fibroblast growth factor, insulin - like growth factor 1, epidermal growth factor, and vascular endothelial growth factor.