Sentences with phrase «including gene families»

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These adaptations include the massive and rapid expansion of gene families that produce venom toxins, providing the snake with a highly toxic protein mixture required to overcome a variety of different prey and also circumvent any resistance to venom that may have developed in such prey.

By providing a woman's family history of these cancers, including the ages they were diagnosed, the programs calculate a probability that the patient carries a harmful mutation in BRCA1 or BRCA2 (genes involved in controlling malignant cell growth).

Nine rare, disease - causing mutations of the gene, FBXL4, were found in nine affected children in seven families, including three siblings from the same family.

Recent studies showed that low oxygen conditions increase levels of a family of proteins known as HIFs, or hypoxia - inducible factors, that turn on hundreds of genes, including one called NANOG that instructs cells to become stem cells.

According to the National Cancer Institute, more than a third of all human cancers, including a high percentage of pancreas, lung and colon cancers are driven by mutations in a family of genes known as Ras.

Among them: some genes believed to be tumor suppressors turned on or became more active, whereas certain disease - promoting ones, including oncogenes (in the so - called RAS family that are implicated in both prostate and breast cancer), were down - regulated or switched off.

A family of neuropeptide genes which includes the gene encoding ELH along with two additional genes encoding the A and B peptides thought to initiate the egg - laying process has been isolated and their nucleotide sequence has been determined.

The protein studied in the mold is part of a larger family of proteins also found in humans and involved in many essential biological processes including gene regulation and fatty acid metabolism.

The study found that 8,600 families of genes are shared across deuterostomes, a large animal grouping that includes a variety of organisms, ranging from acorn worms to star fishes, from frogs to dogs, to humans.

«The most intriguing of these genes is FGFRL1, which has a cluster of amino acid substitutions unique to giraffe that are located in the part of the protein that binds fibroblast growth factors — a family of regulators involved in regulating many processes including embryo development,» Cavener said.

Instead of using the usual small set of DNA markers, both teams compared hundreds of genes from up to 40 spider species to build a family tree that included all the web builders.

And when they sequenced Sputnik's genome, they found its small ring of DNA contained genes from three different viral families, including Mamavirus.

C. krusei, they found, has few copies of gene families associated with pathogenesis in C. albicans, including oligopeptide transporters, aspartyl proteases, and phospholipase B genes.

The researchers» next step is to use the genomic data they collected from the families — including full genome sequences and gene expression data — to begin identifying the specific genes that contribute to risk for bipolar disorder.

They also identify factors that may be involved in duck host immune response to avian virus infection, including the avian and mammalian - defensin gene families.

Although it shows no sign of the whole - genome triplication identified in Solanaceae species such as tomato, the genome includes several species - specific gene family expansions, among them N - methyltransferases (NMTs) involved in caffeine production, defense - related genes, and alkaloid and flavonoid enzymes involved in secondary compound synthesis.

HXR9 targets the HOX gene family, which includes 39 fairly similar genes that help enable the remarkably rapid cell division in growing embryos.

The Milto family raised money for a gene therapy study for Batten disease that included their sons Nathan (right) and PJ.

Aung Ko Win, M.B.B.S., Ph.D., M.P.H., of the University of Melbourne, Victoria, Australia, and colleagues conducted a study that included 1,128 women with an MMR gene mutation identified from the Colon Cancer Family Registry.

The study focused on a small subset of nuclear receptors, a large family of proteins that regulate gene expression in response to signals from various binding partners, including steroids and fats.

As we take our first bites, our parents supply us simultaneously with both nature (genes) and nurture (environment in its broadest sense, including everything from cuisine to family dynamics to religion to cutlery and table manners to the ethics of meat to views on whether it's acceptable to eat food off the floor if it was there for only five seconds).

This sort of horizontal gene transfer across families of bacteria — other relatives include Samonella, Shingella and the plague - causing organism Yersinia — marks a significant finding, Blattner notes.

The vector is a self - inactivating lentivirus — a member of a family of viruses that can insert genes into mammalian cells and drive expression of those genes — that has been engineered to avoid triggering the development of leukemia, a complication seen in previous gene therapy trials for immunodeficiency syndromes, including WAS.

The researchers compared the genes of more than 8,000 white European women — including around 3,250 women diagnosed with ovarian cancer, 3,400 women who did not have cancer and 2,000 women who had a family history of the disease.

Members of a family that includes the apoptosis regulator APAF1 (apoptotic - protease - activating factor 1), mammalian NOD - LRR proteins (also known as NACHT - LRR proteins or CATERPILLERs) and plant disease - resistance gene products.

Contribution to the understanding of how the evolution of gene families relates to functional divergence, including the fate of duplicated genes, horizontal transfer and interspecies hybridization, as well as the characterization of the ancestral patterns of evolution among archosaurs, and the discovery of the late acquisition of mitochondria in eukaryotes (Gabaldón's group, Science 2014, PLoS Biology 2015, PLoS Genetics 2015, Nature 2016).

We discuss the critical role of the BRCA gene family in signaling pathways (including angiogenesis) and evaluate the impacts of the loss - of - function mutations associated with the aforementioned disease.

He foresees a time when patients meet with a physician at age 50 for an assessment that includes blood and gene tests, personal and family history, and talk about diet, habits and behavior.

It was also the first hospital in Spain to include genetic analyses of these genes with the aim of offering better assistance to patients and their families.

The genome encodes a large number of novel receptor kinases and contains expansions of a variety of gene families, including those associated with virulence.

This, and related research, reveals that the bread wheat genome has undergone rapid and significant changes, including loss of gene family members during the time it was being domesticated.

Because the gene shows striking conservation with a corresponding gene family in mammals, including...

GeekWire Award finalists include Bezos Family Immunotherapy Clinic and Nohla Therapeutics, among others; Scientists read infection history in immune genes; and two Hutch faculty members in final class of Kimmel Scholars.

The evolution of mammalian genomes is thought to include at least two whole genome duplications of an ancestral genome (Holland et al., 1994), as well as duplication of sub-chromosomal segments together with extensive gene duplication that has given rise to many large multigene families (Lundin, 1993).

They also include a comprehensive bioinformatics package, enabling you to identify the DNA sequence, clonal prevalence, and V - J family identity for each gene rearrangement.

Experts in pediatric oncology, pediatric surgery, cell and gene therapy including stem cell transplant, radiation oncology, pediatric anesthesia, pharmacology, social work, child life and the full complement of pediatric subspecialty services put a strong focus on family - centered care and emotional support for both the child and the family.

Recently, some other cytokines (such as tumor necrosis factor) or chemical drugs were also found to up - regulate several IFN - inducible gene family members (including RIG - G) through production of type I IFNs (37, 38), further indicating that the induction of RIG - G by ATRA in NB4 cells was tightly related with an IFNα autocrine pathway.

Although we have seen that sponges and eumetazoans share many common pathways related to morphogenesis and cell - type specification, there are notable genomic differences, including different microRNA assemblages46, lineage - specific domains and domain architectures, and the differential expansions of gene families.

DAXX associates with RelB, a transcription factor of the NF - κB family that directly controls the expression of numerous apoptosis - and autophagy - relevant genes, including tumor suppressor protein kinases DAPK1 / 3 [1; 2].

The Alzheimer's trial will include the patients in Colombia whose genetic information was used to develop it - the HD community needs to remember and serve the Venezuelan families where HD is very common and whose DNA helped find the HD gene.

Lysogene's MPS IIIA gene therapy clinical trial strategy includes a partnership with the MPS patient networks to ensure families are well informed about our development program and are able to make informed choices concerning the best treatment strategy for their children.

The researchers discovered striking differences from other invertebrates, including widespread genomic rearrangements and a dramatic expansion of a family of genes involved in neuronal development that was once thought to be unique to vertebrates.

They include genes of the origin of replication complex (orc), the minichromosome maintenance (mcm), and the cell division cycle (cdc) families.

Other gene families that were dramatically expanded in the octopus include zinc finger transcription factors, which are mainly expressed in embryonic and nervous tissues and are thought to play roles in development.

Genes shared with the other members of the New Renault Clio family A long list of safety and travelling comfort equipment has been carried over from New Renault Clio to New Clio Renault Sport, including:

Teresa Barker is a veteran journalist and book writer, whose collaborations include the New York Times bestseller The Big Disconnect: Protecting Childhood and Family Relationships in the Digital Age, with Catherine Steiner - Adair, EdD (HarperCollins 2013), Raising Cain: Protecting the Emotional Lives of Boys (Ballantine 1999) with Michael G. Thompson, Ph.D., and Dan Kindlon, Ph.D.; In the Moment: Celebrating the Everyday, a Literary Guild Holiday Featured Selection with Harvey L. Rich, MD (HarperCollins 2002); Girls Will Be Girls: Raising Confident, Courageous Daughters, a USA Today Top Summer Reading choice, with JoAnn Deak, Ph.D. (Hyperion 2002); Speaking of Boys: Answers to the Most - Asked Questions About Raising Boys (Ballantine 2000) by Michael G. Thompson, Ph.D.; The Creative Age: Awakening Human Potential in the Second Half of Life (Avon 2000), by Gene Cohen, M.D., Ph.D., founding director of the national Center on Aging, and The Mother - Daughter Book Club: How Ten Busy Mothers and Daughters Came Together to Talk, Laugh and Learn Through Their Love of Reading (HarperCollins 1997) by Shireen Dodson, former assistant director of the Smithsonian Institution's Center for African American History.

Siddhartha Mukherjee, author of two popular science books, The Emperor of All Maladies (2010) and The Gene: An Intimate History, has also been open about his family's experience of «madness,» including two uncles and a cousin who all had schizophrenia.

The genetic closeness of the dogs made it easy to pass on certain traits — it just so happens that the traits of the Old Family dogs included not only gameness, but the genes for red noses as well.

,» USA Today and the Los Angeles Times, as well as on a T.V. series including CW's «For Better or Worse,» E!'s «Keeping Up With the Kardashians» and A&E's «Gene Simmons» Family Jewels.»

Dallas Cowboys Announce Art Program for New Stadium 14 Artists Creating Site - Specific Works for Cowboys Stadium, Including Mel Bochner, Olafur Eliasson, Teresita Fernandez, Matthew Ritchie, Lawrence Weiner Unprecedented Art Program Features Monumental Commissions At Key Locations Throughout Cowboys Stadium Arlington, TX (August 7, 2009)-- Dallas Cowboys owners Gene and Jerry Jones, along with their family, today announced the Dallas Cowboys Art Program, an ongoing initiative to commission contemporary artists to create monumental, sitespecific installations for the recently completed Cowboys Stadium.