Sentences with phrase «including gene model»

In both cases, the results are based on the same set of blastp searches, in which we blasted each Nasonia gene against the predicted proteomes of 30 additional species, including 12 additional Hymenoptera genomes, 6 Dipteran genomes, 5 additional insect genomes, 2 additional non-insect arthopod genomes, and 5 non-arthropod outgroup genomes (see Table S4 for the full list, including gene model versions and data sources).

Not exact matches

We've developed a range of tools and techniques to answer today's challenges and plan for the future, including gene technology, digital modelling and region - specific strategies.

So far, gene therapy attempts have only resulted in partial improvements of hearing in mouse models of specific human deafness forms that did not include severe anomalies in hair cell structure.

Page and his colleagues, who use animal models to understand how autism risk factors impact the developing brain and to identify potential treatments for the condition, have found that animals with mutations in the autism risk gene phosphatase and tensin homolog (Pten) mimic aspects of autism, including increased brain size, social deficits and increased repetitive behavior.

Using a mouse model, the team also demonstrated that two processes during neurodevelopment are regulated by the gene: proliferation — the replication of neuronal stem cells that have the potential to become multiple different kinds of cells, including neurons — and migration — the movement of neurons to specific locations in the brain during development.

Computational genomics includes: bio-sequence analysis, gene expression data analysis, phylogenetic analysis, and more specifically pattern recognition and analysis problems such as gene finding, motif finding, gene function prediction, fusion of sequence and expression information, and evolutionary models.

Research areas include species for comparative research; phenotypic characterization; fitness, genome stability and lateral gene transfer; control of organismal traits; monitoring and surveillance; modeling and standardization of methods and data.

«For the first time, we can provide a complete description of an animal model from genes to behavior — including at the level of neuronal network activity, which has been ignored in most studies to date.»

But gene therapy companies - which also include Bluebird Bio, BioMarin, Sangamo and GenSight - may need new business models.

Researchers at Carnegie Mellon University have developed a new dynamic statistical model to visualize changing patterns in networks, including gene expression during developmental periods of the brain.

The results, published in the current issue of Human Molecular Genetics, open the door for pursuing gene editing in nonhuman primates as models for new therapies, including pharmacological, gene - and stem cell - based therapies, said Keith Latham, MSU animal science professor and lead author of the study.

Furthermore, we are testing candidate tissue specific genes using models described in the projects listed below to examine various nutrient responses including fat metabolism, physical activity, intestinal permeability, calcification and aging.

In 2005, Cagan's team created a general fly model of a human thyroid tumor caused by mutations in the Ret receptor tyrosine kinase gene, then screened a panel of drugs including a kinase inhibitor called vandetanib that suppressed the tumor (Cancer Res, 65:3538 - 41, 2005).

Conversely, fundamental research using mouse models can identify genes associated with disease and provide insights into pathogenic mechanisms underlying environment - driven diseases, including infectious diseases and cancer.

In the paper, the model is used to demonstrate a number of these approaches, including detailed investigations of DNA - binding protein dynamics and the identification of new gene functions.

Bethesda, USA (2016 - present) Research areas: Super-resolution microscopy, single - molecule imaging, gene expression, computational modeling and data analysis This section includes all projects during my postdoctoral research stay at the National Institutes of Health in Bethesda, MD (Unites States): (9) Understanding gene expression in eukaryotic cells»

A team of Chinese and American researchers led by Dr. Ji - jing Pang of the Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, PR China, and including Jackson Laboratory scientist Bo Chang, M.D., used gene therapy to restore cone function in the retinas of the B6 (A)- Rpe65rd12 / J (005379) mouse, a model of Leber congenital amaurosis — even if the disease has progressed for three months (Li et al. 2011; Pang et al. 2005).

This included 7 genes with renal function which have never been analysed in a preclinical model before.

With the reference cell census data in hand, the research team is excited to conduct additional studies, including ones involving models or human patients with gastrointestinal conditions — Crohn's disease, ulcerative colitis, gastrointestinal cancers, forms of food allergy, etc. — aimed at identifying changes in gene expression and epithelial structure and function that could reveal new insights and opportunities for therapeutic development.

Population dynamics modeling including individual - based models, gene - based models.

This molecule brings a revolutionary technology platform for genetic engineering in vertebrates, including gene discovery in model species and for therapeutic transgene delivery for possible human applications.

Production of suitable tools (including antibodies) and model systems (including gene modified animals)

Following a Forward Genetics approach, Fleming researchers identified a novel neurological mouse model caused by a functional mutation in the Slc25a46 gene, a new pathogenic target in a wide spectrum of human neurological diseases, including optic atrophy, Charcot - Marie - Tooth type 2, Leigh syndrome, progressive myoclonic ataxia and lethal congenital pontocerebellar hypoplasia.

Research on the most tractable models, such as Drosophila, is greatly advancing our understanding of what specific genes do, including many directly relevant to human biology and medicine.

Key aims include developing new methods to annotate genes (characterize the parts list for biology) and building new methods that learn biological networks, and eventually dynamic models (put the parts together).

In 2017, it will be joined by Anipath, a platform devoted to the histological analysis of small animal models including phenotyping, diagnosis of morbidity cause, in situ gene expression studies.

He later combined it with studies on chromatin, tissue specific gene expression and mouse models for human diseases including Type II diabetes, polycystic kidney disease as well as cancer.

His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function, designing strategies to overcome tolerance and enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate vaccines.

Notably, being induced is positively associated with gene youth (P = 2.96 × 10 − 9), even when including size as a cofactor in the model.

In addition, projects to perform genetic interaction screens on disease genes in model organisms (yeast, worm, fly, fish) will not be considered, unless the project includes substantive specific aims that investigate the disease relevance of any new genes discovered in human or mammalian model systems.

Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection of actively maintained mouse models; determining molecular networks implicated in pathological disruption of the retinal pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role of gene variants that increase the risk of age - related macular degeneration as identified by human genome - wide association studies.

For example, by using histone deacetylase (HDAC) inhibitors, which, by remodeling chromatin structure, are thought to promote gene expression broadly, including for SMN2, numerous groups showed that they could increase SMN protein levels — both truncated and full - length — in mouse models of SMA as well as in patient - derived cell lines.

The ENSEMBL gene models are also included.

LOS ALAMOS, N.M., Jan. 31, 2018 — Using a simple analytical framework for random events within a predictable system, computational biologists have found a new way to accurately model certain forms of gene expression, including the body's 24 - hour internal clock.

This curation effort has resulted in several improvements to the gene set including the addition of UTRs to gene models, correction of gene boundaries and exons, and the discovery of nearly 650 new genes.

Many of the model organism databases (MODs) used by members of the GSA community — including FlyBase, WormBase, SGD, ZFIN, and MGI — have been supported by NIH's National Human Genome Research Institute (NHGRI), along with others supporting human and other research — such as OMIM, the Gene Ontology Consortium, and UniProt.

Our approaches include gene discovery, mapping of signaling networks in cell culture models and in vivo functional analyses done through gene knock - out and knock - in techniques in mice.

Full - length transcript models produced by CLS enabled us to definitively characterize the genomic features of lncRNAs, including promoter and gene structure, and protein - coding potential.

Analyzing the first 3,328 genes identified models for 360 diseases, including the first models, to our knowledge, for type C Bernard - Soulier, Bardet - Biedl - 5 and Gordon Holmes syndromes.

Frequently, a typical omics classification includes redundant and irrelevant features (e.g. genes or proteins) that can result in long computation times; decrease of the model performance and the selection of suboptimal features (genes and proteins) after the classification / regression step.

The 120 repeat R6 / 2 mouse model of HD expresses a human transgene containing exon 1 of the mutant huntingtin gene and faithfully replicates many of the symptoms of the disease, including progressive loss of body weight, marked impairments in cognition, and severe motor deficits.

This particular iPS - based ALS model includes a gene mutation that produces TDP - 43, a protein commonly found in most forms of ALS.

The MMRRC at UC Davis received 604 strains for a total of 495 mutant alleles, including the secreted and trans - membrane protein models, and knockout models targeting 23 other genes from the Genentech and Lexicon Pharmaceutical collaboration.

Speakers will discuss applications of patient - specific and disease - specific stem cell lines, including gene repair (via tools such as the Cas9 nuclease), disease modeling, drug screening, and regenerative medicine.

Some scientific problems with modern paleo movement include: 1) dogmatic insistence on the Raymond Dart model of «man the hunter», which has been contested and supplanted in paleoanthropology for decades; 2) ignorance about the speed of evolutionary adaptation, for example our very recent acquisition of lactase persistence and high amylase gene number; 3) focus on the diets of 80 - 10,000 years ago, dismissing the 40 million years when our lineage were predominantly herbivorous forest dwellers.

Various modes of inheritance of epilepsy have been deduced in different breeds, including simple autosomal recessive 3 with a sex - modifier 4, 5, polygenic recessive 6 with a sex - predilection 7, polygenic with a large contribution by a single autosomal recessive gene 8, and a multi-locus model 9.

It was assumed that if the data sets had a normal residual distribution when fitting the polygenic models, normality was maintained when the models were extended to include the major gene effects.

In order to analyze sex differences statistically, both the main and interaction terms of sex and the genes of interest must be included in the same model.