Sentences with phrase «including gene regulation»

The protein studied in the mold is part of a larger family of proteins also found in humans and involved in many essential biological processes including gene regulation and fatty acid metabolism.

Not exact matches

The newly unmasked genes play a role in three distinctively different bodily functions, including systems that control inflammation and cholesterol and the regulation of how brain cells clean up toxic proteins.

Histones are proteins vital for gene regulation, and histone modifications are central to regulation of many chromosome - related processes, including DNA replication, transcription and repair.

The researchers linked the excess weight and changes in metabolism to epigenetic modifications that reduce expression of the gene for adiponectin — a hormone that helps regulate several metabolic processes, including glucose regulation.

A «perfect storm» leads to the collapse of almost all the molecular functions of SRY, including cellular trafficking, stability, DNA recognition and gene regulation.»

Genes with mammoth - specific changes were most strongly linked to fat metabolism (including brown fat regulation), insulin signaling, skin and hair development (including genes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the ArGenes with mammoth - specific changes were most strongly linked to fat metabolism (including brown fat regulation), insulin signaling, skin and hair development (including genes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the Argenes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the Arctic.

This cross-species gene regulation, which includes genes that contribute to the host plant's defense against parasites, has never before been seen from a parasitic plant.

The open portions of the genome include genes themselves, as well as many regions that contribute to the regulation of their activities (the switches).

The research that led to these findings is part of a larger effort to better understand gene regulation and expression, carried out by the GTEx Consortium, a National Institutes of Health - funded group that includes researchers from around 80 institutions founded in 2010.

At present, the regulation of gene drive research does not fit within the purview of any of the U.S. agencies involved in the Coordinated Framework for the Regulation of Biotechnology, which includes the Food and Drug Administration, U.S. Department of Agriculture, and the U.S. Environmental Protectiregulation of gene drive research does not fit within the purview of any of the U.S. agencies involved in the Coordinated Framework for the Regulation of Biotechnology, which includes the Food and Drug Administration, U.S. Department of Agriculture, and the U.S. Environmental ProtectiRegulation of Biotechnology, which includes the Food and Drug Administration, U.S. Department of Agriculture, and the U.S. Environmental Protection Agency.

Examples include gene technology, where regulations in China are not as stringent as in the United States.

Hypermethylation of DNA is a key epigenetic mechanism for the silencing of many genes, including those for cell cycle regulation, receptors, DNA repair, and apoptosis (5, 6, 7, 8).

Epigenetics involves the regulation of genomic functions, including gene expression.

Transcriptional regulation information for a gene, including any predicted DNA binding site motifs (YeTFaSCo) for the gene's protein product, as well as any of its targets (genes it regulates) or regulators (genes that regulate it), based on experimental evidence.

The work has led him to explore the role of protein phosphorylation in a diverse array of cellular functions, including transformation, cell communication, cell adhesion, cell - cycle regulation, the control of gene expression, and protein degradation.

Since they confer regulation on the majority of human genes, it is not surprising that microRNAs are involved in numerous biological processes, including cardiovascular, immunological, neurodegenerative, and psychiatric diseases and cancer.

We also identify genes involved in electrolyte metabolism and homeostasis, including NR3C2, SCPEP1, WNK2, and CACNA1D, with important direct (47, 48) and indirect (49) physiological consequences for blood pressure regulation.

He cloned and characterized many of the genes that are key in the regulation of glucose metabolism including insulin, glucagon, glucose transporters and many others.

Studies could include examining the activation and deactivation of genes (e.g., transcription factors or epigenetic regulation) or involve more classical genetic identification studies.

These include molecular evolution of transcription factors or changes in transcriptional regulation (Enard et al., 2002; Konopka et al., 2009), accelerated evolution of small non-coding RNAs (Pollard et al., 2006), changes in the tissue - specificity of enhancer elements (McLean et al., 2011; Prabhakar et al., 2008), or changes in patterns of alternative splicing of specific genes (Calarco et al., 2007).

Upon salt - stress treatment, Arabidopsis mobilizes a complex set of pathways that includes alterations in the regulation of gene expression and metabolic adjustments that attempt to establish a new

Sessions will cover recent findings in RNA polymerase II regulation, including the contributions of noncoding RNAs, chromatin structure and post-translational modifications, and other factors that regulate gene expression.

The range of subjects includes, but is not limited to, immune cell development and senescence, signal transduction, gene regulation, innate and adaptive immunity, autoimmunity, infectious disease, allergy and asthma, transplantation, and tumor immunology.

In a paper published in Nature Genetics, an interdisciplinary research team of scientists from the Centre for Genomic Regulation (CRG)-- including a Centro Nacional de Análisis Genómico (CNAG - CRG) group — in Barcelona, Spain, shows that the three - dimensional organisation of the genome plays a key role in gene expression and consequently in determining cell fate.

Examples of these include cell proliferation, intracellular targeting, cell polarity, membrane traffic, cell migration, stem cell biology, chromatin regulation and function, differentiation, morphogenesis and biomechanics, and regeneration and cellular homeostasis, as well as developmental roles of genes, cellular structural dynamics, and signaling pathways.

This modification is of special interest to p53 - dependent anti-senescence and pro-longevity functions because genetically engineered mice with p53 serine18 mutated to alanine (p53S18A) show increased ROS levels, metabolic stress, tumor frequency, premature aging symptoms and defects in regulation of a subset of p53 target genes that include sestrins.

Researchers at the Center work on a wide variety of applications, including autism, cancer, neuroscience, plant biology, gene regulation and evolution.

Major areas of activity in our lab include 1) identification and characterization of Sgenes, 2) genomic analyses to identify the diversity of TAL effectors in pathogen populations and understand their evolution, and 3) structural and biochemical studies to better harness the unique properties of these proteins for applications such as targeted gene regulation and genome editing.

The current findings could provide important clues to determine the culture conditions for promoting the differentiation of primate ES cells into mature gametes, and to understand molecular mechanisms of primate gametogenesis including the timing of germ cell induction, the regulation of germ cell gene expression, and the response to growth factors for germ cell differentiation.

Other molecular mechanisms linking the cloned 13.5 kb ws1 region to wing size evolution could also occur, including cis - regulation of prospero, changes in non-coding RNAs, or long - distance regulation of another gene.

Throughout the 2000s, Wistar scientists made seminal discoveries in the field of epigenetics and RNA transcription, contributing new knowledge on the role of histone modifications in gene regulation and DNA repair and how different RNA species, including microRNAs (miRNA) and long noncoding RNAs (lncRNA), are generated and how they regulate gene transcription.

TiGER (Tissue - specific Gene Expression and Regulation) is a database that provides comprehensive information about postnatal human tissue - specific gene regulation, including expression (from EST studies) and regulatory elemeGene Expression and Regulation) is a database that provides comprehensive information about postnatal human tissue - specific gene regulation, including expression (from EST studies) and regulatoryRegulation) is a database that provides comprehensive information about postnatal human tissue - specific gene regulation, including expression (from EST studies) and regulatory elemegene regulation, including expression (from EST studies) and regulatoryregulation, including expression (from EST studies) and regulatory elements.

(6) Zinc is an essential mineral that is an imperative part of many functions in the body, including the structure in many proteins and enzymes and regulation of gene expression.

Studies to date have demonstrated that phytochemicals in common fruit and vegetables can have complementary and overlapping mechanisms of action, including modulation of detoxification enzymes, scavenging of oxidative agents, stimulation of the immune system, regulation of gene expression in cell proliferation and apoptosis, hormone metabolism, and antibacterial and antiviral effects (15, 16).

A host of other such genes exist, including MTHFR (folate, vitamin B metabolism), FTO (body weight and fat composition), TCF7L2 (blood sugar regulation), APOE ε4 (cholesterol) and FADS1 (fatty acid metabolism).

Disruption of the gene leads to the development of cataracts via multiple pathways, including the down - regulation or loss of post-translational modification of different crystallin proteins [102].

``... several animal studies indicate serious health risks associated with GM food consumption including infertility, immune dysregulation, accelerated aging, dysregulation of genes associated with cholesterol synthesis, insulin regulation, cell signaling, and protein formation, and changes in the liver, kidney, spleen and gastrointestinal system.»

Two SNPs from the TPH1 gene were included even though their functionality is not yet clarified because this gene is involved in the regulation of serotonin synthesis in the body (as opposed to the brain) and given previous research to implicate low levels of peripheral serotonin this gene was an important inclusion.