Sentences with phrase «including genetic studies»

We need research to robustly test the ADHD - phenocopy hypothesis, including genetic studies that incorporate, or control, epigenetic phenomena.

Studies may involve laboratory or clinical investigation, including genetic studies, but the Program will not sponsor therapeutic trials.

Not exact matches

By Kraig Kraft The Search for the Origins of Chile Peppers Starts in Arizona As a graduate student studying crop evolution at U.C. Davis, I am focusing my work on describing the genetic changes that took place during the domestication of Capsicum annuum, a species that includes some of the most common varieties of chile peppers cultivated worldwide.

However, this study only included kids at high - risk for celiac (based on genetic markers or a first - degree relative with the disease), so it might not apply to the general population.

These limitations and complexities include bias in socioeconomic class and other environmental and genetic factors that are difficult to control, particularly in small studies.

Because there is a clear genetic predisposition to IBD, these populations should probably be composed of families that include persons who already have IBD [such as the studies conducted by Koletzko et al (20, 26)-RSB-.

The study results build on genetic and epigenetic basics, including that the blueprint for the human body is encoded in genes that direct the building of one or more proteins.

According to Dr. Philip Awadalla, senior author and principal investigator, «the fact that two very close populations (French versus French Canadians) accumulate such an excess of differences in rare variants has important consequences in the design of genetic studies, including the identification of possibly damaging mutations associated with diseases specific to this population.»

The project was supported by a USDA NIFA grant, and the study's authors include researchers from the National Program for Genetic Improvement of Feed Efficiency in Beef Cattle, as well as associated graduate students and staff.

African populations harbour the greatest genetic diversity and have the highest per capita health burden, yet they are rarely included in large genome studies of disease association.

Evidence includes: «moderate genetic influences demonstrated in well - sampled twin studies; the cross-culturally robust fraternal - birth - order effect on male sexual orientation; and the finding that when infant boys are surgically and socially «changed» into girls, their eventual sexual orientation is unchanged (i.e., they remain sexually attracted to females).

Indeed, he notes, it's improbable that all of the previous genetic studies of red deer, including those living throughout Europe today, wouldn't have picked up any of the haplotypes he and his team identified in their new research.

The largest of its kind, the study examined genetic data in 100,000 individuals including 40,000 people with a diagnosis of schizophrenia and also found that some of the genes identified as increasing risk for schizophrenia have previously been associated with other neurodevelopmental disorders, including intellectual disability and autism spectrum disorders.

Two study aims were to use novel whole - genome sequence data to (1) study possible correlations between language groups and genetic clustering, and (2) investigate the ancestral compositions of these individuals, including maternal and paternal lineages.

In conducting their study, which includes detailed behavioral, medical and genetic observations of 14 boys with CS from 12 families, the team of scientists and physicians worked closely with families of the small but fast - growing Christianson Syndrome Association, including hosting the group's inaugural conference at Brown's Alpert Medical School last summer.

Using a novel combination of technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

Yet a new study finds that people who harbor one of two genetic variants seem to have a heightened risk of the cancer if they take aspirin or NSAIDs, drugs that include ibuprofen and naproxen.

In all, the study included the data of more than 23,000 people to show that approximately 12 percent of a person's variation in delay discounting can be attributed to genetics — not a single gene, but numerous genetic variants that also influence several other psychiatric and behavioral traits.

The study's cohort of Quebec twins, which included 223 sets of monozygotic twins (with an identical genetic code) and 332 sets of fraternal twins, made it possible to determine whether the individual differences observed in proactive and reactive aggression were due to genetic or environmental factors.

The study also included genetic data from eight extant species, including the three largest lemur species still alive today.

The study illustrates the genetic foundation of evolution, including how genes can flow from one species to another, and how different versions of a gene within a species can contribute to the formation of entirely new species, the researchers report in the journal Nature.

The major role that genetic variation of rDNA appears to have and the fact that rDNA analysis would not have been included in these studies could explain some of this missing heritability.

As far as we're aware, it's the first study worldwide to show this in such detail, including a large number of genetic variants.»

Ko is quick to note that these new findings do not warrant radical dietary changes in people with Crohn's: More studies, including more refined genetic analyses of fatty acids and Crohn's and testing in animal models, are needed.

In a March 2009 study published in Genes and Immunity, researchers at the National Center for Computational Toxicology compared the genetic signatures of 16 people who experienced smallpox vaccine side effects, including fever, rashes and enlarged lymph nodes, to 45 people who did not.

Marcelino and Swain anticipate that as the rarer algae types are further studied, the algorithm will eventually include rankings for all different genetic types.

A landmark international study of DNA samples from 520,000 individuals worldwide — including 67,000 affected individuals — identified 22 new genetic risk factors for stroke.

Researchers conducted an analysis that included nearly 10,000 women with the BRCA1 or BRCA2 genetic mutations to estimate the age - specific risk of breast or ovarian cancer for women with these mutations, according to a study published by JAMA.

The research team, including members of Prof. Keinan's lab, Prof. Eitan Friedman of TAU's Sackler School of Medicine, and Prof. Gil Azmon and colleagues at Albert Einstein College of Medicine and the University of Haifa, based their study on data from the Jewish HapMap project, an international effort led by Prof. Harry Ostrer of Albert Einstein College of Medicine, to determine the genetic history of worldwide Jewish diasporas.

Apart from the number of participants, the strengths of this study include the use of three different methods to achieve acurate measurement results: cerebrospinal fluid samples, the use of a so - called PET scanner, and genetic analysis.

Now, a new study that included genetic data from more than 190,000 people has identified two genes that, when altered in specific ways, either promote or undermine cardiovascular health.

A new study offers insights into the genetic changes that accompany the evolution of social complexity in bees, including honey bees.

An international team of scientists, led by researchers from the University of Tuebingen and the Max Planck Institute for the Science of Human History in Jena, successfully recovered and analyzed ancient DNA from Egyptian mummies dating from approximately 1400 BCE to 400 CE, including the first genome - wide nuclear data from three individuals, establishing ancient Egyptian mummies as a reliable source for genetic material to study the ancient past.

By including data from both identical and fraternal twins who were raised together, the study seeks to account for both environmental and genetic contributions.

C.elegans has been used for decades as a model animal to study the genetic and molecular underpinnings of neurological disorders through a number of techniques including bio imaging, electrophysiology and behavior.

They're now working on a GWA study, which includes genetic data from the just - published work plus DNA samples from more than 1000 additional gay men.

Following up on clues — including the fact that PMS is 56 percent heritable — the NIH researchers studied the genetic control of gene expression in cultured white blood cell lines from women with PMDD and controls.

Additionally, they hope to use the Purkinje cell platform to study other ASD - related genetic disorders, including Fragile X and SHANK3 mutation, and to test potential drugs.

To conduct the study, Matthew Robinson, a postdoc in the lab of geneticist Peter Visscher at the University of Queensland in Brisbane, Australia, and colleagues turned to large databases that include information on human physical and genetic traits.

In a new study, researchers at Boston Children's Hospital used stem cell technology to create cerebellar cells known as Purkinje cells from patients with tuberous sclerosis complex (TSC), a genetic syndrome that often includes ASD - like features.

The study was the first to suggest a genetic component to what the researchers called «intrinsic religiousness,» which includes the tendency to pray often and to feel the presence of God.

They believe this mouse model can be promptly implemented to find genetic markers, conduct meticulous studies on how symptoms originate and take hold, and evaluate drugs and that have broad spectrum anti-viral activities against all Zaire ebolaviruses, including the one responsible for the current West African epidemic.

Other potential uses of embryonic stem cells include investigation of early human development, study of genetic disease and as in vitro systems for toxicology testing.

Preliminary genetic evidence included in the study suggests that the enzyme, called SNRK, performs similar functions in humans, making it an intriguing new drug target in the battle against obesity and its complications.

Valentina Coia explains further: «The first hypothesis could not be ruled out given that the study considered only 85 modern comparison samples from the K1 lineage — the genetic lineage that also includes that of Ötzi — which comprised few samples from Europe and especially none from the eastern Alps, which are home to populations that presumably have a genetic continuity with the Iceman.

In addition to genetic data and microbiome composition, the information collected for each study participant included dietary habits, lifestyle, medications and additional measurements.

The selected proposals include research on genetic switches to study microbial ecosystems, tools for deciphering multi-kingdom communication molecules, and a novel approach to map interactions between bacteria species.

In the course of this work, he has pioneered several new approaches in the fruit fly that have had important implications for mammalian neurobiology, including: the demonstration that the fruit fly has a sleep - like behavior similar to that of mammals, studies of physiological and behavioral consequences of mutations in a neurotransmitter system affecting one of the brain's principal chemical signals, studies making highly localized genetic alterations in the nervous system to alter behavior, and molecular identification of genes causing naturally occurring variation in behavior.

Fallin's interests are in applying genetic epidemiology methods to studies of neuropsychiatric disorders including autism, Alzheimer's disease, schizophrenia, and bipolar disorder and in developing applications and methods for epigenetic epidemiology, particularly as applied to mental health and development.

Last month, a new study found that roughly 70 percent of women who carry cancer - predisposing mutations in the genes BRCA1 and BRCA2 (the main genes included in genetic tests for breast cancer patients) will develop breast cancer, often in early adulthood.