Sentences with phrase «including humans and mice»

But mammals (including humans and mice) seem to have missed out on this important skill.

In many mammals, including humans and mice, the PRDM9 protein marks where recombination will take place — the molecular equivalent of the orange flags that utility crews use to mark digging locations.

The new MIT system appears to work for many cell types — so far, the researchers have successfully tested it with more than a dozen types, including both human and mouse cells.

The result was a highly selective drug they named SBI - 0206965, which successfully killed a number of cancer cell types, including human and mouse lung cancer cells and human brain cancer cells, some of which were previously shown to be particularly reliant on cellular recycling.

Not exact matches

Several species of mammal, including mice, rats and dogs, are able to sniff out disease in humans and other animals.

So he implanted various human tumors — including ovarian, breast, colon, liver, and brain — into mice and then injected the animals with antibodies that disable CD47.

This consortium selected 44 separate sections of the genome that included regions of high to low gene density and high to low similarity between mouse and human.

The IGF1 protein is crucial for the growth of mammals, including mice and humans, so Ostrander's group and other collaborators began collecting DNA from additional breeds to see if they also shared the same gene variant.

Several species, including Arabidopsis, rice, mice and humans, copy a surprising amount of RNA from the «wrong» DNA strand — that is, the strand opposite the one that specifies a protein.

Scientists have assumed these tunes are hardwired in their tiny mouse brains and doubted that rodents modify their songs after hearing others — a cognitive feat similar to vocalizations by birds and some mammals, including dolphins, bats and humans.

Chronic treatment with rapamycin has been problematic in both humans and mice; the drug has the potential to cause deleterious metabolic side effects including weight gain and glucose insensitivity.

«These two studies highlight the value of using an integrated multi-systems approach — including fruit flies, mice, and human cells — to discover mechanisms underlying disease processes.»

Like all mammals, including humans, mice lose up to a third of their muscle mass and power as they get older.

When they delivered this virus into the noses of mice and ferrets, the animals» epithelial cells produced the desired antibodies; they then «challenged» the animals with a range of dangerous influenza viruses that no single vaccine can outwit, including H5N1, which kills both birds and humans, and the H1N1 that caused the infamous 1918 pandemic.

Similar to humans, the mice developed tumors at secondary sites including the liver, lung, peritoneum, and diaphragm.

The study, conducted in mice and including analyses of human cancers, found very high levels of two proteins — dectin - 1 and galectin - 9 — in pancreatic tumors.

For the animal study, the researchers separated 52 mice with colon cancer tumors into three groups, including a control group and groups that were fed either the grape compounds or sulindac, an anti-inflammatory drug, which was chosen because a previous study showed it significantly reduced the number of tumors in humans.

Titze and his colleagues, Tobias Riede of Midwestern University in Glendale, Arizona and Ted Mau of the University of Texas Southwestern Medical Center, compiled measurements of larynx characteristics for 16 species, including humans and animals ranging from mice to elephants.

She analyzes the comparative histopathology of genetically altered mice and models of human diseases, including cancer, inflammatory disorders, and microbial infections.

First author Antonio Di Meco and colleagues used a triple transgenic (3xTg) mouse model that displays an AD - like phenotype, including cognitive decline, and Aβ and tau neuropathology characteristic of the disease in humans.

Green fluorescent protein labeling allowed them to see the early development pattern and show that lncND, which ordinarily is not present in mice — lncND is present only in some primates including humans — had a functional effect on development.

(Elephant protein sequences in present databases are incomplete, so other matches for the mastodon turned up among more distantly related mammals, including dogs, cows, mice, and humans.)

Dr. Spangenburg and colleagues, including researchers from the University of Maryland School of Medicine, Brigham Young University, Karolinska Institutet in Sweden, and East Carolina University, found that the BRCA1 protein exists in both mouse and in human skeletal muscle.

Not only is genetic modification easier in mice, but it is likely to become much more feasible in a wide range of other species, including pigs, fish, monkeys, and even humans.

The researchers published their views of nine cell types, including cancer cells in both humans and mice, in the December 18, 2014, issue of Cell.

Improvements on this scale happened in all the animals, including mice with a version of human Alzheimer's disease, elderly rats and monkeys with natural degeneration, plus rats and monkeys given brain lesions similar to those seen in Alzheimer's.

The findings, now published in PLOS Genetics, reveal how mice can actually mimic human breast cancer tissue and its genes, even more so than previously thought, as well as other cancers including lung, oral and esophagus.

The current research team, which includes Dr. Minoda and Dr. Hiroki Takeda of Kumamoto University, and several researchers from Keio University, have successfully grafted human iPS - derived cells into the inner ear of embryonic mice, a feat with a high level of technical difficulty.

A total of 24 genes including a gene called Aipl1 — standing for aryl hydrocarbon receptor interacting protein like 1 — have been linked to LCA in humans and mice.

The DNA of BKV has been discovered in several types of human cancers including prostate tumours, and mouse studies suggest the virus can trigger cancer.

After residing with this pugnacious roommate for ten days, many mice developed symptoms that resemble depression in humans, including anxiety, social avoidance and difficulty sleeping.

The next steps in this line of research include tests on whether boosting the effects of FGF21 can help limit or reverse liver damage in mice and decrease a preference for alcohol in humans.

Mice that lack the fmr1 gene (and therefore lack the FMRP protein) show some of the same symptoms of human FXS, including seizures, impaired sleep, abnormal social relationships, and learning defects.

These mice have their hemoglobin genes removed and replaced with the mutated human version, saddling them with many of the same problems as human sufferers, including immature, short - lived, and sickle - shaped red blood cells; anemia; reduced blood flow; and an enlarged spleen.

«We think that by restoring the natural «microbial identity» of laboratory mice, we will improve the modeling of complex diseases of free - living mammals, which includes humans and their diseases,» said Barbara Rehermann, M.D., senior author of the paper.

A total of 24 genes including a gene called Aipl1 — standing for aryl hydrocarbon receptor interacting protein like 1 - have been linked to LCA in humans and mice.

Importantly, intraperitoneal inoculation of pancreatic homogenates containing IAPP aggregates into transgenic mice expressing human IAPP dramatically accelerates IAPP amyloid deposition, which was accompanied by clinical abnormalities typical of T2D, including hyperglycemia, impaired glucose tolerance, and a substantial reduction on β cell number and mass.

Next steps include He's collaboration with Piedmont Atlanta Hospital to retrieve T cells, liver cancer cells and healthy tissue normally removed from patients during surgery, put the mouse receptor genes on these T cells and monitor in a dish both how those cells now fight the tumor and react to healthy human tissue.

We designed a virtual version of the assay for human subjects that includes the visible - target training, hidden - target learning, and probe trials that are typically administered in the mouse version.

Experimental models include yeast, mammalian and human cell lines, mutant mouse models and tumour samples.

More recently, I have demonstrated the feasibility of using fMRI in combination with pharmaco - genetic silencing to dissect the circuital basis of complex behaviors, and demonstrated for the first time that the mouse brain contains distributed resting - state functional connectivity networks, including plausible homologues of the human default - mode (DMN) and salience networks.

Corley also leads a $ 1.6 - million project that will be the first attempt to construct a physiologically based pharmacokinetic (PBPK) model for application to multiple species, including mouse and human.

Cultured mouse, monkey, and human pluripotent cells can be driven down a retinal lineage as determined by the expression of marker genes, including the EFTFs [2]--[4].

We have found that expression of C3 in normal mouse eyes leads to pathology similar to AMD in humans, including the creation of anaphylatoxins and the MAC.

An international team of scientists, including four from Brown University, conducted and analyzed tests using a «knock - in» mouse carrying a gene for a mutant DNA / RNA binding protein called TDP - 43, which causes a form of inherited ALS in humans.

The George lab has made seminal contributions to the field including: discovering a novel population of neurons in the brain of humans, rats and mice that are involved in nicotine dependence, identifying neuronal ensembles responsible for nicotine and alcohol addiction, and unveiled the cellular and molecular changes associates with long term use of nicotine, cocaine, methamphetamine and alcohol use on the brain.

Genetically engineered mice now act as robust engines for the generation of diverse repertoires of affinity - matured, fully - human variable regions with intrinsic drug - like properties necessary for successful development including high potency, specificity, manufacturability, solubility and low risk of immunogenicity.

Methods: The PNNL mass spectra data used by the team included samples taken from a diverse set of more than 100 organisms, including humans, the common house mouse, and the metal - reducing bacterium Shewanella oneidensis.

Researchers have produced knockout mice with characteristics similar to humans suffering from a wide range of disorders, including cancer, heart disease, neurological disorders and even obesity.

«Over the past ten years, several research groups, including our own, have shown the importance of certain immune cell subsets in preventing or exacerbating heart disease in mice, but we are just beginning to understand how the metabolism and function of these immune cells change during cardiovascular disease progression in humans,» says Hedrick.