Sentences with phrase «including immune molecules»

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The experiments included sorting immune cells found at injury sites by molecules on their cellular surfaces, and many hours looking at mouse cells through the microscope.

Rac1 is an important molecule in healthy cells, including immune cells.

The molecule regulates genes that suppress immune surveillance mechanisms, including the production of cells that inhibit the immune response.

Hoping to develop a more potent approach, medical oncologist Ron Levy of Stanford University in Palo Alto, California, and colleagues used mice to test the cancer - fighting capabilities of some 20 molecules, including several types of antibodies that activate immune cells.

They have discovered that «itaconate» — a molecule derived from glucose — acts as a powerful off - switch for macrophages, which are the cells in the immune system that lie at the heart of many inflammatory diseases including arthritis, inflammatory bowel disease and heart disease.

Biologics — a class of compounds created by biological processes instead of chemistry — include a range of antibodies, interleukins (proteins and molecules critical to the function of the immune system), and vaccines.

To find out, the team genetically modified mice to block production of Nppb in TRPV1 neurons, then injected the skin on their shoulders with a range of itch - inducing compounds, including histamine, an inflammatory molecule involved in immune responses, and the malaria drug chloroquine.

Allergies, including food allergies, are caused when our immune system produces antibodies to destroy «enemy» molecules, like those from bacteria and viruses.

The gene activity also pointed to a role for immune cells such as neutrophils, which launch a full - fledged inflammatory reaction, including the release of molecules that stimulate contractions of the uterus.

Richard Axel and colleagues, including Leonard Chess and Dan Littman, identify T4 (CD4) as the molecule that enables HIV to enter immune system cells.

The immune system includes primary immune organs, such as the thymus and bone marrow, where immunocytes differentiate; secondary immune organs like the lymph nodes and spleen, where immunocytes identify foreign molecules and initiate responses against them, then radiating and patrolling through the body.

Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.

LIGHT is largely regarded as a pro-inflammatory molecule that might regulate multiple aspects of the immune response including controlling T cell functionality.

The new drug combination included Nivolumab, which blocks pD - 1 — a molecule that prevents immune cells recognizing and attacking cancer cells — with ipilimumab which sensitizes the immune system to cancer cells.

He will now investigate a set of molecules called TLR agonists that act through receptors on the surfaces of innate immune cells to set off a chain reaction of molecular signaling and activation within the immune system, which includes activation of latently infected CD4 cells.

The final aim is improving therapeutic effect and defining rationalized drug combinations with immune checkpoints and proprietary molecules developed by collaborators, including novel immunomodulatory approaches generated at our unit.

She has been instrumental in establishing in vitroand in vivo models of malaria pre-erythrocytic stages sanctioned for the analysis of host immune responses and identification of host molecules that are crucial for hepatic development of the Plasmodium parasite including CD81 and SRB1.

NO is critical signalling molecule involved in many cellular and physiological processes, including, but not limited to: blood circulation, immune defence and neurotransmission.

Our immune system relies on protein for production of other molecules as well, including complement proteins that are critical in supporting the function of our white blood cells.

Intracellular levels of NAD + regulate immune and inflammatory pathways, including the cytokine TNF - alpha, a critical signaling molecule.34, 35