Sentences with phrase «including lung tumors»

The HRT group faced persistently higher risks for other malignancies, including lung tumors.

Not exact matches

«Nonetheless, the proof of concept studies we have obtained thus far are extremely encouraging, and we are confident that with proper support and efforts we could translate our findings into experimental therapeutics for a variety of solid tumors that are driven by EphA2 overexpression, including breast, lung, prostate, pancreatic, and ovarian cancers,» said Pellecchia, who serves as the founding director of the Center for Molecular and Translational Medicine at UCR.

The Wnt pathway is known to be inappropriately activated in many major tumor types, including colon, breast, liver, lung and pancreatic cancers, and is critical for the function of CSCs.

The findings also have potential uses for most other types of solid tumors, including those affecting the lungs and ovaries, because the same protein and enzyme are involved, François said.

Heeke says the study would be open to people whose tumors have evidence of HRD like those found in this study, which includes bladder, breast, cervix, liver and bile duct, colorectal, endometrial, gastric / esophageal, head & neck, kidney, neuroendocrine, lung, ovarian, pancreas, prostate, sarcoma, and thyroid cancers, as well as gastrointestinal stromal tumors, glioma, melanoma and unknown primary cancers.

One of those genes, K - Ras, which was discovered nearly 30 years ago, is mutated in 30 percent of human tumors, including 90 percent of pancreatic cancers, 40 percent of colon cancers, and 20 percent of non-small cell lung cancers.

Similar to humans, the mice developed tumors at secondary sites including the liver, lung, peritoneum, and diaphragm.

The MRI imaging detected metastatic tumors, including micrometastases, in lung, liver, lymph node, adrenal gland, bone, and brains of the mice.

Global Cancer Facts and Figures, 2nd Edition, a report released in 2011 by The American Cancer Society, notes that cancers related to changing lifestyles as nations become wealthier, including lung, breast, and colorectal tumors, continue to rise in the developing world http://www.cancer.org/Research/CancerFactsFigures/GlobalCancerFactsFigures/global-facts-figures-2nd-ed

Myc is a proto - oncogene or master cancer gene that spurs tumor growth in a variety of cancers including breast, lung, colon, brain, skin, leukemia, prostate, pancreas, stomach and bladder.

Previous research, including pioneering work at MD Anderson by this study's senior author Ignacio Wistuba, M.D., and others, has shown normal - appearing tissue close to lung premalignant and cancer lesions may have tumor - associated molecular abnormalities.

She says they can now identify the mechanisms that cause tumor growth in half of all adenocarcinomas, a family of cancer that affects skin and other tissue, including the lungs.

The results from our new study suggest that entinostat may enhance the anti-tumor efficacy of PD - 1 targeted therapy through MDSC targeting, potentially providing an effective combination treatment approach for patients with solid tumors, including lung and renal cell carcinoma.»

The study's findings, published in the journal Cancer Research, are the first to use these combined agents as an immune stimulator and may have the potential to kill cancerous cells in solid tumors, including some of the most aggressive cancers that form in the lung and pancreas.

«BMI1 plays a substantial role in many solid tumors, including one of the most aggressive models of lung cancer, and its expression is linked with tumor growth, invasion, metastasis, prognosis and recurrence,» Levantini said.

Checkpoint inhibitors such as ipilimumab, nivolumab and pembrolizumab have had a dramatic impact on treatment of several tumor types, including melanoma, lung cancer, head and neck cancers and others.

Being both tumor - specific and widely expressed in human tumors, MAGE - A3 is an ideal cancer vaccine target and will be the focus of many clinical trials, including the largest clinical trial ever conducted in lung cancer, MAGRIT, launched by GlaxoSmithKline in 2007.

The companies have launched a phase II trial of the antibody - drug conjugate, and are also testing it in other solid tumors, including ovarian and non — small - cell lung cancers.

It can be proposed that p21 contributes to mediate p53 - dependent tumor suppression in some tumor types, which would include histiocytic sarcomas, hemangiomas, B - cell lymphomas, and lung carcinomas, but not in other tumor types, particularly spontaneous or radiation - induced T - cell lymphomas.

«What we see over and over in trying to treat some of the most aggressive and intractable cancers, including many lung, brain, ovarian, breast, melanoma and sarcoma tumors, is that the tumor fights back.

Li - Fraumeni syndrome (LFS) is a genetic disorder associated with an increased risk of developing several forms of cancer, including soft tissue sarcoma, breast cancer, leukemia, lung cancer, brain tumors and adrenal gland tumors.

The researchers write that expression of DNRII also may be useful for other tumors that exploit this immune evasion mechanism, including melanoma and lung cancer.

The study evaluated the efficacy and safety of cabozantinib compared to placebo in 9 different solid tumor types including breast, lung, ovarian, and prostate.

Mutations in the beta - catenin gene, or flaws in the factors that degrade it, have long been linked to more aggressive disease in various tumor types, including colon, lung and prostate cancer, and melanoma.

Cancer Institute research highlights include innovative studies to develop individualized approaches for treatment and prevention of lung cancer; collaboration between medical and materials science researchers to develop treatments for various types of leukemia using nanotechnology to target only cancer cells; and development of novel therapeutics to treat metastatic melanoma using an approach that regulates the processes leading to tumor development.

In certain tumor groups, subtypes have been included, e.g. breast cancer includes both ductal and lobular cancer, lung cancer includes both squamous cell carcinoma and adenocarcinoma and liver cancer includes both hepatocellular and cholangiocellular carcinoma etc..

Flavopiridol inhibits several cellular kinases and has demonstrated cytostatic and cytotoxic activity in vitro and in vivo in numerous human tumor cell lines and xenograft models (including human breast, prostate, and lung carcinoma) at clinically achievable concentrations.

However, some testicular tumors can grow aggressively and metastasize (spread) to other parts of the body, most commonly to the lymph nodes, lungs, liver and central nervous system, including the brain and spinal cord.

He also treats liver, kidney, skeletal and lung tumors with ablative techniques, including cryoablation as well as radiofrequency and microwave ablation.

If clinical trials of anti-PD-1 continue to show promising results, cancer patients may soon have access to another powerful immunotherapy for the treatment of numerous cancers, including melanoma, non-small cell lung cancer, and other solid tumors.

Her current focus is on developing clinical protocols for the treatment of head and neck and lung cancers with a goal of providing enhanced tumor control, including control of metastases, with minimal effect of quality of life.

These include imatinib, sold under the brand name Gleevec for chronic myeloid leukemia; gefitinib, sold as Iressa for metastatic non-small cell lung cancer; and sunitinib, marketed as Sutent, for renal cell cancer and gastrointestinal stromal tumors.

The featured lung cancer study, for instance, not only used synthetic vitamin E (tocopheryl) but also neglected to include any tocotrienols, which have previously been shown to kill cancer stem cells, the most malignant of all cells with a tumor.5 As noted by Dr. Andrew Saul, the study was set up to fail: 6

The Chinese have regarded it as a detoxifying herb that can be used to boost the immune system, and for a number of serious conditions including uterine, breast, and lung tumors.

Parsley has been shown to reduce tumors in the lungs and to neutralize the effects of carcinogens, including cigarette smoke.

The range of diseases that need to be ruled out include Kennel cough, infection, collapsing trachea, laryneal paralysis, heart disease, heartworms, lungworms, fungal diseases and lung tumors.

Signs of heart failure, lung tumors, and even choking in a dog will include heavy panting, breathing difficulty, and coughing.

These diseases include infectious pneumonia (fungal, bacterial, parasitic), feline heartworm disease (cats are aberrant hosts for the canine heartworm disease parasite), primary lung parasites, and tumor disease (either a lung tumor, or one that has metastasized or spread to the lungs from elsewhere in the body).

X-rays can be used to detect a variety of ailments including arthritis, tumors and lung abnormalities including pneumonia, bladder and kidney stones.

Exams include a lung and heart check, eyes, ears, skin and coat and abdominal check for tumors.

Inside the body, tumors frequently affect many organs systems simultaneously, including the spleen, liver, lymph nodes, lungs, bone marrow, brain and central nervous system, and joints.

Surgical procedures include spay, neuter, tumor removal, foreign body retrieval, resection of intestines, lung lobe resections, fracture fixation by bone plating, intramedullary pinning, and external skeletal fixation, and amputation.

Other, but rarer, causes of metastatic calcification include kidney disease (this is the most common cause in cats), malignant tumors producing abnormal hormones that increase blood calcium concentrations (e.g. tumors of the lymphoid system and glands of the anal sac), diabetes mellitus and lung disease.

Another main trigger is the involuntary movement of the hairlike cilia in the respiratory tract which remove foreign matter from the air before it gets into the lungs, but other underlying causes can include mucous irritation, obstruction of the nasal passage, inflammation, excess nasal discharge or secretion, pneumonia, chronic vomiting, GI disease, and nasal tumors and dental diseases in older dogs.

Common conditions addressed by soft tissue surgeons include exterior masses, serious wounds, upper airway and oral cavity diseases, surgically resectable benign and malignant tumors and surgical conditions of the heart, lungs and other internal organs.

Initial evaluation of a dog with a suspected bone tumor often includes: complete physical exam, blood tests, radiographs (both the primary site and the lungs), and a biopsy.

Fast forward to Sept, after beginning treatments for glaucoma with pain meds, and exhibiting unusual behaviors with greater frequency, including greatly reduced interest in food over her last 5 days, her xrays showed both lungs fully involved with metastatic tumors.