Sentences with phrase «including myopathies»

«This could therefore have an impact on the treatment of muscular diseases, including myopathies and muscular dystrophies.»

Not exact matches

The major categories of these devastating wasting diseases include: muscular dystrophy, congenital myopathy and metabolic myopathy.

These are the muscular dystrophies (among which are Duchenne and Becker); motor neuron diseases (including ALS and SMA); the peripheral nerve disorders (CMT and Friedreich's ataxia); inflammatory myopathies; disorders of the neuromuscular junction; metabolic diseases of muscle as well as other myopathies.

Known side effects include an increase in the risk of diabetes (50 - 100 new cases per 10,000 people), haemorrhagic strokes (5 - 10 per 10,000) and myopathy (5 per 10,000).

In addition to the Great Danes, researchers, including Laporte, have found Labrador retrievers that bear two other gene mutations that cause different forms of recessive centronuclear myopathy, one linked to chromosome 2 and the other to the X chromosome.

Peripheral nervous system complications of sepsis include two conditions, critical illness polyneuropathy and critical illness myopathy, which cause muscle weakness and inability to wean from a ventilator.

More broadly, he said, «These findings are part of an emerging theme that there is a whole spectrum of diseases that includes ALS, and some forms of dementia and myopathy, that are caused by disturbance in the behavior of these structures that perturbs cellular organization.»

These findings are generally consistent with those from recent systematic reviews, some of which also included trials of statins for secondary prevention.47,51 - 53 Similar to other meta - analyses of primary and secondary prevention trials, 54,55 this review found no association between use of statins and increased risk of muscle - related harms, although some observational studies and randomized rechallenge trials found statins associated with increased risk of myopathy or joint - related symptoms.56 - 58 The large HOPE - 3 trial found statins associated with increased risk of cataract surgery, an unanticipated finding.14 No other trial of statins for primary prevention evaluated risk of cataracts or cataract surgery.

The Division of Pulmonary Medicine deals with the breath of life in all its aspects: control of breathing; sleep disorders; obstruction to airflow in the common diseases of upper and lower airways such as croup, bronchiolitis, asthma, cystic fibrosis, and bronchopulmonary dysplasia; restriction to lung function from disorders affecting the chest wall, the musculature, the nervous system, or lung tissue itself; congenital anomalies; accidents such as inhalation of foreign bodies, hydrocarbons, or toxic gases; secondary effects of non-pulmonary system disorders such as gastrointestinal reflux, myopathy, or cardiac dysfunction; disease of the upper respiratory tract including rhinitis and sinusitis; and so on.

Abstract Type 1 ryanodine receptor (RyR1) is preferentially expressed in skeletal muscle, and mutations in the gene have been associated with malignant hyperthermia, a pharmacogenetic disease, and with several congenital myopathies, including central core disease, multiminicore disease, centronuclear myopathy, congenital fibre type disproportion.

Defects in these genes are associated with several forms of myopathies (41), including limb - girdle muscular dystrophy 2F, which causes limb musculature wasting and locomotory troubles in juvenile individuals.

Sialic acid synthesis is tightly regulated; defects in this pathway cause a variety of disorders, including hereditary inclusion body myopathy (HIBM), sialuria, infantile sialic acid storage disease (ISSD), and Salla disease.

Utilising the RDRF, we have deployed national and international patient - driven and clinical registries including: the Myotubular and Centronuclear Myopathy Patient Registry, the Global Angelman Syndrome Registry, the Familial Hypercholesterolaemia Australasia Network Registry, and the Australian and New Zealand Neuromuscular Disorders Registries (Duchenne Muscular Dystrophy, Spinal Muscular Atrophy, and Myotonic Dystrophy Registries).

In addition, HER2 is expressed in many normal tissues, giving systemic HER2 - targeted antibody therapy the potential to cause toxicity in a subset of patients, including cardiac myopathy, congestive heart failure, and pulmonary toxicity [14], [15].

Symptoms may include muscle pain, muscle degradation (myopathy), or severe muscle damage.

Other side effects may include aggression, altered serum creatinine levels, anorexia, anxiety, burping, confusion, constipation, depression, drowsiness, elevated liver enzymes, fainting, fever, headaches, heat intolerance, increased cortisol or insulin levels, increased symptoms of deep vein thrombosis, jaundice, lightheadedness, liver injury, mania, metabolic acidosis, myopathy (muscle disease), rhabdomyolysis (muscle breakdown), seizures, skin rashes, vomiting, worsening sleep problems, yellowing of the skin irregular heart rhythm (arrhythmia) and pigmented purpuric dermatosis [3,6].

Neurological manifestations, including ataxia, epileptic seizures, dementia, migraine, neuropathy, myopathy and multifocal leucoencephalopathy

Some of the inherited disorders known to affect the breed include hip dysplasia, patellar luxation, progressive retinal atrophy and hereditary myopathy.

Labs are healthy dogs overall, and a responsible breeder screens breeding stock for conditions such as elbow and hip dysplasia, heart disorders, hereditary myopathy (muscle weakness), and eye conditions, including progressive retinal atrophy.

The UMN College of Veterinary Medicine has updated their Canine Genetic Testing webpage to include submission forms and instructions for submitting samples for Dutch Shepherd Inflammatory Myopathy (Myositis) testing.

A number of serious neurological / neuromuscular diseases affect Labrador Retrievers, including polyneuropathy (centronuclear myopathy), laryngeal paralysis, megaesophagus, myasthenia gravis, cerebellar ataxia, narcolepsy, and also vague head tremors that may be the result of unknown abnormalities in the brain.

We've contributed to the development of genetic screening tests for multiple equine diseases, including combined immunodeficiency disease, equine type I polysaccharide storage myopathy, and lavender foal syndrome.