Sentences with phrase «increase efficacy of therapy»

Depletion of gram - positive bacteria within the gut, using an antibiotic called vancomycin, also increased the efficacy of the therapy, improving the anti-tumor response and overall remission rate in less - responsive mice.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

«Our findings point to the importance of physicians counseling their patients regarding the potential harms of smoking interfering with the efficacy of therapies and for increased risks of side effects.»

«We report much higher therapeutic efficacy in preclinical brain tumor models using the combination of both therapies, leading to an increase in median survival,» Lowenstein says.

Scientists at the Universitat Autònoma de Barcelona (UAB) and the Catalan Institute for Nanoscience and Nanotechnology (ICN2) have developed a nanoencapsulation system with a liposome coating in order to increase the efficacy of bacteriophages in oral phage therapy.

In the sensitive tumor models, the ability of anti — cytotoxic T lymphocyte — associated protein 4 or anti — programmed cell death 1 therapy to increase vessel perfusion strongly correlated with its antitumor efficacy.

Therefore, in order to increase the efficacy of therapeutic treatments, combination therapies are commonly administered.

ERK1 / 2 inhibition increases antiestrogen treatment efficacy by interfering with hypoxia - induced downregulation of ERalpha: a combination therapy potentially targeting hypoxic and dormant tumor cells

In 2002, the Women's Health Initiative, the first study of its kind to test the safety and efficacy of HRT, released results on the increased risk of breast cancer and stroke among menopausal women taking combined hormone replacement therapy.

«Requiring new treatments to show either greater efficacy or acceptability than an existing standard therapy would serve as a disincentive to the development of me - too agents that offer little to patients other than increased costs,» they write.

SOUND ® has taken its 20 + years of veterinary experience and developed a therapy laser with an innovation beyond what currently exists in the market: a built - in laser training assistant specifically designed to increase efficacy and consistency of clinical results.

Risk of relapse among patients diagnosed with major depressive disorder is high (> 50 % of those recovering from a first episode of depression, and approximately 80 % of those with a history of two or more episodes), 1 and this risk increases with each successive depressive episode.2 Several clinical trials have demonstrated that mindfulness - based cognitive therapy (MBCT) significantly reduces relapse risk among patients with three or more prior depressive episodes.3 Yet, MBCT contains multiple therapeutic elements, and the specific efficacy of the mindfulness training element in MBCT is unknown.

Collaborative therapy aims to increase consumer participation and encourage self - efficacy and self - reliance through psycho - education, with an emphasis on the development of coping skills and strategies.

«Lisa Dion has created a training program that both increases the efficacy of play therapy and also leads therapists on a journey of authenticity.»

Summary: (To include comparison groups, outcomes, measures, notable limitations) This study assessed the efficacy of Trauma - Focused Cognitive - Behavioral Therapy (TF - CBT) delivered by social worker facilitators in reducing posttraumatic stress, depression, anxiety, and conduct problems and increasing prosocial behavior in a group of war - affected, sexually exploited girls.