The discharge appears because your vagina's walls are beginning to thicken and there is
an increase growth of cells.
Not exact matches
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain
growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may
increase the amount
of discount required on Gilead's products; an
increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability
of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction
of generic versions
of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect
of lowering prices or reducing the number
of insured patients; the possibility
of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels
of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize
cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits
of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages
of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development
of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate
of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
We anticipate some sort
of growth toward
increased complexity: increasingly larger organic macromolecules, then the convergence
of many macromolecules to constitute a simple living system, either as a
cell with its protective wall and vital nucleus or as some functional analogue, then the convergence
of many
cells to form larger organisms.
It seems to decrease
cell growth,
increase self - destruction
of abnormal
cells and shift estrogen metabolism to less cancer - promoting forms.»
«You're giving people a hormone that canpotentially
increase the
growth of abnormal
cells.»
«In animal studies, exercise has been shown to specifically affect the hippocampus, significantly
increasing the
growth of new neurons and
cell survival, enhancing memory and learning, and
increasing molecules that are involved in the plasticity
of the brain,» Chaddock said.
They found that exercise may help cognition by
increasing blood and oxygen to the brain,
increasing levels
of norepinephrine, and endorphins to decrease stress and improve mood, and
increasing growth factors that help create new nerve
cells and support synaptic plasticity.
«When a new substance forms during a chemical reaction, many students think that the atoms and molecules have actually changed into something new, whereas they simply rearranged, that the mass
increase of plants is due to minerals in the soil, or that
cell division alone accounts for animal
growth,» said Cari Herrmann Abell, a senior research associate at Project 2061.
After EZH2 enzymes rise, their levels taper off, and then, the scientists found two to three-fold
increases in a protein called DNMT1, which maintains DNA methylation in the «start» location
of a variety
of tumor suppressor genes that normally suppress
cell growth.
Meanwhile, recent human studies indicate that aging is associated with an
increase in somatic mutations in the hematopoietic system, which gives rise to blood
cells; these mutations provide a competitive
growth advantage to the mutant hematopoietic
cells, allowing for their clonal expansion — a process that has been shown to be associated with a greater incidence
of atherosclerosis, though specifically how remains unclear.
The researchers took this discovery and, in an animal model, identified a drug that is able to re-activate those immune
cells and reduce brain tumor
growth, thereby
increasing the lifespan
of mice two to three times.
In support
of this finding, experiments also revealed that an
increase in cellular TIP60 levels could inhibit cancer
cell growth.
In addition, scientists found an
increase in the markers for the
growth of cancerous
cells and liver inflammation in both groups exposed to the carcinogen.
Increasing levels
of PUMA only affected stem - like
cells that were starting to spread and not the
growth of primary tumors.
Frigo and his team demonstrated in this study that androgens take control
of the AMPK signaling cascade, a master regulator
of metabolism, to
increase prostate cancer
cell growth.
Eventually, she says, it might be possible to use our
increased understanding
of RFX transcription factor to treat hearing loss, by either protecting hair
cells from death or fostering their
growth.
Increased SQLE expression promotes the biosynthesis
of cholesteryl ester, which induces NAFLD - HCC
cell growth.
The study found that the insulin - like
growth factor 1 (IGF - 1) hormone, known for its pivotal role in tissue
growth, is also capable
of increasing the lithium sensitivity
of blood
cells in bipolar disorder patients in whom lithium was originally ineffective.
Auxin promotes
cell division and
growth,
increasing weight and firmness
of the fruit.
They discovered that IGF2BP3 binds to and stabilizes hundreds
of leukemia - promoting RNA messages and consequently
increases how much protein is made, resulting in an environment that is conducive to leukemia
cell growth.
«We found that E. lignolyticus SCF1 is capable
of degrading 56 - percent
of the lignin under anaerobic conditions within 48 hours, with
increased cell abundance in lignin - amended compared to unamended
growth,» Simmons says.
They found higher levels
of JAK1 in resistant tumors, which caused
increased expression
of epidermal
growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes
cell proliferation.
The team found that individuals with long - standing type 1 diabetes and diabetic enteropathy have altered colonic stem
cells (CoSCs) and
increased blood levels
of a regulatory protein called insulin - like
growth factor binding protein 3 (IGFBP3), which is produced in the liver.
Plant
growth occurs by
increasing the number
of cells by
cell division followed by enlargement
of the
cells.
Therapies could seek to
increase or decrease the amount
of HIF to deliver more oxygen to anemic
cells or suppress cancerous
growth.
Through a variety
of preclinical experiments, the team demonstrated that
increasing the expression
of miR - 184 slows the
growth and invasive characteristics
of glioma
cells through direct regulation
of SND1.
They promote the
growth of cancerous
cells by releasing
growth factors and
increasing the response
of certain proteins that regulate tumor
cell development (oncoproteins).
Using this marker, the green fluorescence
of the nucleus
increases progressively in
cells in the
growth phase and turns off after the division.
Moreover, injection
of 5E5 CAR T
cells into mice with leukemia or pancreatic cancer reduced tumor
growth and
increased survival.
The data are the same across papers, and so are the conclusions: The molecule is a powerful inhibitor
of cancer
cell growth, and it
increases the sensitivity
of cancer
cells to radiotherapy.
The group observed that, at the cellular level, one
of the side effects
of the diet was an expansion
of hair follicle stem
cells, leading to
increasing hair follicle
growth and retention rates.
However, an overactive stimulation
of mTOR in response to nutrients and
growth factors — metabolic processes that are crucial in tumor biology — leads to an
increase in
cell growth and proliferation.
Other studies show that visceral obesity raises a person's risk
of developing colon cancer, perhaps because it
increases circulating levels
of hormones that affect
cell growth.
They found that the drug
increased the level
of lactate in
cells and, more importantly, reduced tumour
growth.
They have a burst
of growth that
increases the pool
of cells waiting for the next mutation to push them even further.
A more alkaline
growth medium, for example, made the autoinducer less stable, slowing activation
of the
cell - suicide gene and
increasing the population.
Either drink delivers a sugar shot that
increases insulin and insulinlike
growth factor, «both
of [which] promote inflammation and both lead to cancer
cell division,» says Abrams, who is also professor
of clinical medicine at U.C.S.F., and chief
of hematotology / oncology at San Francisco General Hospital.
When a chemical that inhibits entosis was applied to a line
of breast cancer
cells, colony formation — an indicator
of tumor
growth in vitro —
increased 10-fold.
In contrast, the
growth of clones derived from progenitor
cells becomes checked by
increasing levels
of apoptosis, leading to the formation
of benign lesions.
Like volunteers handing out cups
of energy drinks to marathon runners, specially engineered «helper
cells» transplanted along with stem
cells can dole out
growth factors to
increase the stem
cells» endurance, at least briefly, Johns Hopkins researchers report.
Additionally, overexpression
of POSTN in human mammary epithelial and breast cancer
cells resulted in enhanced tumor
growth and metastasis (Wang et al., 2013), which is similar to a colon cancer
cell model where overexpression
of POSTN resulted in an
increase in the number and size
of liver metastases (Bao et al., 2004).
Biologically, hypermethylation often silences genes that keep runaway
cell growth in check, and its appearance in the DNA code
of breast cancer - related genes shed into the blood may indicate that a patient's cancer
growth is
increasing and the disease has worsened.
Mutations in the gene
increase rat susceptibility to mammary cancer and FRY reduced the
growth of highly aggressive human breast cancer
cells.
The frequency
of CD39highCD8 + T
cells increased with tumor
growth but was absent in lymphoid organs.
Leukemic
cells can feed themselves through
increased secretion
of hepatocyte
growth factor (HGF), which then activates its receptor, MET, to promote
growth.
In this study these
cells were treated with a combination
of gamma secretase inhibitor and BRAF inhibitor, a reduction in
cell growth and an
increase in senescence was observed in these resistant
cells.
Autocrine fibroblast
growth factor 2
increases the multipotentiality
of human adipose - derived mesenchymal stem
cells.
Finally, we demonstrate that treatment
of T - 47D
cells with epidermal
growth factor (EGF), which promotes
cell ruffling, stimulates
increased accumulation
of activated matriptase at the sites
of membrane ruffling, suggesting a possible functional role at these sites.
Increased transforming
growth factor beta expression inhibits
cell proliferation in vitro, yet
increases tumorigenicity and tumor
growth of Meth A sarcoma
cells.
The TRPC channel blocker SKF 96365 Inhibits Glioblastoma
Cell Growth by Enhancing Reverse Mode
of the Na + / Ca2 + Exchanger and
Increasing Intracellular Ca2 +.