Sentences with phrase «increase in human diseases»

Such environmental degradation, coupled with the growth in world population, is major causes behind the rapid increase in human diseases.

Not exact matches

But we have dramatically reduced poverty, shown ways to build institutions that respect human rights and liberties, virtually eliminated famines, found ways to prevent and remedy diseases, dramatically increased the longevity of people everywhere, and come to include more and more persons in the «circle of exchange.»

Disease and early mortality, which were understandably judged to be evil, nonetheless kept in check the natural increase in human population.

For amid all the advantages of contemporary life, where fewer people suffer disease, hunger, or lack of opportunity than in years past, there still is probably no increase in the sum total of human happiness and very slight advantage, if any, in the main business of making sense of one's life.»

These include the infant with galactosemia, 53,54 the infant whose mother uses illegal drugs, 55 the infant whose mother has untreated active tuberculosis, and the infant in the United States whose mother has been infected with the human immunodeficiency virus.56, 57 In countries with populations at increased risk for other infectious diseases and nutritional deficiencies resulting in infant death, the mortality risks associated with not breastfeeding may outweigh the possible risks of acquiring human immunodeficiency virus infection.58 Although most prescribed and over-the-counter medications are safe for the breastfed infant, there are a few medications that mothers may need to take that may make it necessary to interrupt breastfeeding temporarilin the United States whose mother has been infected with the human immunodeficiency virus.56, 57 In countries with populations at increased risk for other infectious diseases and nutritional deficiencies resulting in infant death, the mortality risks associated with not breastfeeding may outweigh the possible risks of acquiring human immunodeficiency virus infection.58 Although most prescribed and over-the-counter medications are safe for the breastfed infant, there are a few medications that mothers may need to take that may make it necessary to interrupt breastfeeding temporarilIn countries with populations at increased risk for other infectious diseases and nutritional deficiencies resulting in infant death, the mortality risks associated with not breastfeeding may outweigh the possible risks of acquiring human immunodeficiency virus infection.58 Although most prescribed and over-the-counter medications are safe for the breastfed infant, there are a few medications that mothers may need to take that may make it necessary to interrupt breastfeeding temporarilin infant death, the mortality risks associated with not breastfeeding may outweigh the possible risks of acquiring human immunodeficiency virus infection.58 Although most prescribed and over-the-counter medications are safe for the breastfed infant, there are a few medications that mothers may need to take that may make it necessary to interrupt breastfeeding temporarily.

Physiologic sleep studies have found that breastfed infants are more easily aroused from sleep than their formula - fed counterparts.247, 248 In addition, breastfeeding results in a decreased incidence of diarrhea, upper and lower respiratory infections, and other infectious diseases249 that are associated with an increased vulnerability to SIDS and provides overall immune system benefits from maternal antibodies and micronutrients in human milk.250, 251 Exclusive breastfeeding for 6 months has been found to be more protective against infectious diseases compared with exclusive breastfeeding to 4 months of age and partial breastfeeding thereafter.2In addition, breastfeeding results in a decreased incidence of diarrhea, upper and lower respiratory infections, and other infectious diseases249 that are associated with an increased vulnerability to SIDS and provides overall immune system benefits from maternal antibodies and micronutrients in human milk.250, 251 Exclusive breastfeeding for 6 months has been found to be more protective against infectious diseases compared with exclusive breastfeeding to 4 months of age and partial breastfeeding thereafter.2in a decreased incidence of diarrhea, upper and lower respiratory infections, and other infectious diseases249 that are associated with an increased vulnerability to SIDS and provides overall immune system benefits from maternal antibodies and micronutrients in human milk.250, 251 Exclusive breastfeeding for 6 months has been found to be more protective against infectious diseases compared with exclusive breastfeeding to 4 months of age and partial breastfeeding thereafter.2in human milk.250, 251 Exclusive breastfeeding for 6 months has been found to be more protective against infectious diseases compared with exclusive breastfeeding to 4 months of age and partial breastfeeding thereafter.249

«Now, using genomic methods that were not available 10 years ago, it appears that components made by the virus interact with human DNA in the places where the genetic risk of disease is increased,» Harley says.

«But in this case, when this virus infects cells, the virus makes its own transcription factors, and those sit on the human genome at lupus risk variants (and at the variants for other diseases) and that's what we suspect is increasing risk for the disease.»

«Much like the spread of human disease in populated areas, urban centers can foster increases in multiple disease types in wild animals,» said McGraw, senior author of the study.

IN A rare instance of humans beating one of the impacts of climate change, measures to combat malaria appear to be neutralising the expected global increase of the disease driven by rising temperatures.

With global increase in obesity and diet - related metabolic diseases, interest has intensified in ancestral or «Palaeolithic» diets, not least because — to a first order of approximation — human physiology should be optimized for the nutritional profiles we have experienced during our evolution.

Buttke is interested in using public interest in personal health as a way to increase support for public green space, and enhancing public understanding of how human actions can drive infectious disease spread through a variety of avenues including school programs, websites, and smart phone apps.

To maintain its foothold in large - scale, world - class research, Japan has launched its own Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain / MINDS) project, in line with the increasing interest in brain - mapping projects around the world, such as the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative project in the United States and the Human Brain Project (HBP) in Europe.

«The next step in understanding sleep apnea in the future will be to dissect different subtypes of sleep apnea, likely defined by distinct pathophysiological mechanisms which may underlie different outcomes and predisposition to comorbidities,» Cavadas says, «As human life expectancy increases, delaying the onset of age - related diseases becomes critical to our society.»

«If lowering of LDL cholesterol affects atherosclerosis in humans in the same way, our observations mean that clinically advanced plaques could be prevented if cholesterol - lowering treatments are administered early enough in individuals with increased risk of cardiovascular disease.

The findings indicate that not only might Oprl1 become dysregulated in humans following the development of PTSD, but inherited variants of the disease could increase the likelihood of someone developing the disorder to begin with.

When mice with the disease were given increased amounts of the protein PGC -1-alpha, which is naturally present in both mice and humans, the neural decay was dramatically reduced.

He analyzed data on 6,000 American women collected by the Centers for Disease Control and Prevention and found that concentrations of mercury in the human population had increased over time.

So far there have been no reports of Parkinson's disease in human survivors of the H5N1 flu, Smeyne says, but because only a few years have passed since the first cases were reported, it's too early to know whether those infected are at increased risk.

And in tracking human disease patterns, she's established a clear link between such low - dose chronic exposure and increases in high blood pressure and heart disease.

Since 1996, major changes in infectious diseases have occurred, such as the introduction of human immunodeficiency virus (HIV) / AIDS and West Nile virus into the United States, advances in HIV / AIDS treatment, changes in vaccine perceptions, and increased concern over drug - resistant pathogens.

As the human population in West Africa has grown, people have increasing contact with wildlife, which has aided the spread of zoonotic diseases.

Acute sleep loss in humans is associated with increased appetite and insulin insensitivity, while chronically sleep - deprived individuals are more likely to develop obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease.

Humans are considered uniquely susceptible to Alzheimer's disease, potentially due to genetic differences, changes in brain structure and function during evolution, and an increased lifespan.

In recent years, interest in this fifth DNA base has increased by showing that alterations in the methyl - cytosine contribute to the development of many human diseases, including canceIn recent years, interest in this fifth DNA base has increased by showing that alterations in the methyl - cytosine contribute to the development of many human diseases, including cancein this fifth DNA base has increased by showing that alterations in the methyl - cytosine contribute to the development of many human diseases, including cancein the methyl - cytosine contribute to the development of many human diseases, including cancer.

Animals with gene mutations that significantly alter their circadian rhythms have shorter life spans, and circadian rhythm sleep disorders in humans can have profoundly negative effects, including increased risk for obesity, depression, cardiovascular disease and cancer.

The new NIST human genome RMs increase the ability of DNA sequencing laboratories to be more confident in their reporting of true positives, false positives, true negatives and false negatives, and therefore, significantly improve genetic tests used for disease risk prediction, diagnosis, and progression tracking.

«The dramatic increase in these diseases has occurred amidst constant human genetics, suggesting a pivotal role for an environmental factor,» said Chassaing, assistant professor in the Institute for Biomedical Sciences.

Research has shown that giving TMAO to rodents promotes atherosclerosis and that humans with higher concentrations of TMAO in the bloodstream are at increased risk of developing heart disease.

«Recent increases in chronic diseases like childhood asthma and autism can not be due to major shifts in the human gene pool,» says physician and geneticist Francis Collins, former director of the National Human Genome Research Instihuman gene pool,» says physician and geneticist Francis Collins, former director of the National Human Genome Research InstiHuman Genome Research Institute.

«We want to see how much variability there is in this phenomenon in the healthy human population, to evaluate if there is a correlation between retrotransposition frequency and brain tumor formation, and to see whether it is increased or reduced in Alzheimer's disease.»

The selective loss of large herbivores, for instance, is known to cause relatively systematic increases in abundance of rodents [71], which are thought to be particularly effective at hosting and transmitting human - borne zoonoses, thus driving landscape - level increases in rodent - borne disease [72].

Climate change effects on the geographical distribution and incidence of vector - borne diseases in other countries where these diseases are already found can also affect North Americans, especially as a result of increasing trade with, and travel to, tropical and subtropical areas.63, 197 Whether climate change in the U.S. will increase the chances of domestically acquiring diseases such as dengue fever is uncertain, due to vector - control efforts and lifestyle factors, such as time spent indoors, that reduce human - insect contact.

As researchers team up with computer scientists to develop powerful algorithms and machine learning tools, they are increasing their capacity to identify patterns in huge datasets of biological information and reveal unknown connections to human disease.

Although of course there are a number of caveats since mice can be cured from cancer at higher rates, they don't suffer from some of our diseases, they are sensitive to being handled (if grabbing them can shorten their lifespan through stress, the mouse version of standard human medical care may do the same), so I guess that increases in maximum lifespan are indeed the only reliable indicator that an intervention is impacting age - related mortality.

In other words, do human impacts on biodiversity increase the prevalence of diseases by eroding natural «checks and balances» on transmission or decrease prevalence when they remove the free - living biodiversity on which disease agents depend?

Bethesda, Md. (January 24, 2018)-- A review of more than 80 studies reveals that changes in the immune cells of people with human immunodeficiency virus (HIV) infection may increase their risk of cardiovascular disease (CVD).

Health improvement (allowing to post - pone / escape the diseases and thus live, healthier / disease - free longer, but not above human MLSP of around 122 years; thus these therapies do not affect epigenetic aging whatsoever, they are degenerative aging problems not regular healthy aging problem (except OncoSENS - only when you Already Have Cancer - which cancer increases epigenetic aging, but cancer removal thus does not change anything / makes no difference about what happens in the other cells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to MLSP).

Our increased understanding in areas such as stem - cell biology, human immune systems, and identification of disease - specific biomarkers all have contributed significantly to that progress.

10/29/2008 Eating Red Meat Sets Up Target for Disease - Causing Bacteria Non-human molecules absorbed by eating red meat increase risk of food poisoning in humans Offering another reason why eating red meat could be bad for you, an international research team, including University of California, San Diego School of Medic... More...

In the article describing the work in Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they writIn the article describing the work in Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they writin Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they writin gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they write.

In light of the widespread role of oxidative stress in the pathology of diverse human diseases and the ability of the Nrf2 - dependent antioxidant response gene network to protect against oxidative stress, considerable effort has been directed towards discovering compounds that can increase the activity of NrfIn light of the widespread role of oxidative stress in the pathology of diverse human diseases and the ability of the Nrf2 - dependent antioxidant response gene network to protect against oxidative stress, considerable effort has been directed towards discovering compounds that can increase the activity of Nrfin the pathology of diverse human diseases and the ability of the Nrf2 - dependent antioxidant response gene network to protect against oxidative stress, considerable effort has been directed towards discovering compounds that can increase the activity of Nrf2.

Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection of actively maintained mouse models; determining molecular networks implicated in pathological disruption of the retinal pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role of gene variants that increase the risk of age - related macular degeneration as identified by human genome - wide association studies.

One of the goals of this research is to increase our understanding of human mitochondrial diseases caused by translation defects in this organelle.

Infected patients are at - risk for long - term joint stiffness and pain, which increases the need to better understand the sequence diversity of these viruses and how any viral mutations affect the severity of disease in the human host.

Major problems in high TB disease burden countries are human and environmental factors that contribute to a weakened immune system and can increase susceptibility to Mtb infection, recurrence of latent infection and high morbidity and mortality.

Analyzes whole genome and detailed clinical data from nearly 300,000 Icelanders Finds several novel variations in the sequence of the human genome modulating cholesterol levels Five variants are also causally linked to increased risk of coronary artery disease Shows...

Only in the last 10 years, with increasing knowledge of the senescent phenotype and the ability to detect senescent cells in human tissues, have biologists been able to investigate the relationship between cellular senescence and disease.

Translational medicine is the integrated application of innovative pharmacology tools, biomarkers, clinical methods, clinical technologies and study designs to improve disease understanding, confidence in human drug targets and increase confidence in drug candidates, understand the therapeutic index in humans, enhance cost - effective decision making in exploratory development and increase phase II success.

Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96