An additional study in infant macaques, which mimicked exposure to a hormone also associated with
increased schizophrenia risk, produced similar results.
Not exact matches
Studies suggest that diet and stress modify sperm epigenetically and
increase an offspring's
risk of heart disease, autism and
schizophrenia.
«The regular use of cannabis is known to be associated with an
increase in the
risk of later developing psychotic illnesses including
schizophrenia.
While some evidence was found to support hypotheses that cannabis use is a contributory factor in
increasing the
risk of
schizophrenia, the researchers were surprised to find stronger evidence that the opposite was also likely.
People who have a greater
risk of developing
schizophrenia are more likely to try cannabis, according to new research, which also found a causal link between trying the drug and an
increased risk of the condition.
15 years after a gene defect was found to
increase the
risk of
schizophrenia 30-fold, scientists have figured out how it might cause the brain disorder's debilitating symptoms
The medications excel at quelling hallucinations and delusions, yet largely fail to address
schizophrenia's debilitating cognitive and social impairments, while
increasing risk for movement disorders, weight gain, and other metabolic and cardiovascular side effects.
Now a large survey using data from all patients hospitalized in psychiatric wards in Israel, and their siblings, has given some answers: having a sibling with
schizophrenia increases your
risk of developing the condition by a factor of x10, with
increased risks of developing bipolar disorder and other mental disorders.
Dr Antonio Pardiñas, first author of the study, said: «We show for the first time that genetic variants that do not severely impact gene function, but presumably have a more subtle impact on these critical genes,
increase risk for developing
schizophrenia.»
In Europe and China, a series of large - population studies confirmed that mutations in the area of the genome controlling MHCI
increase the
risk of
schizophrenia.
«Genetics researchers close in on
schizophrenia: 50 new gene regions that
increase risk of developing
schizophrenia.»
The largest of its kind, the study examined genetic data in 100,000 individuals including 40,000 people with a diagnosis of
schizophrenia and also found that some of the genes identified as
increasing risk for
schizophrenia have previously been associated with other neurodevelopmental disorders, including intellectual disability and autism spectrum disorders.
Indeed, low birth weight, a marker of impaired fetal development, is associated with
increased everyday levels of inflammatory markers as well as greater
risks of heart disease, diabetes, depression and
schizophrenia in adults.
People with depression and
schizophrenia are known to have a much higher
risk of developing heart disease and diabetes, and elevated levels of IL - 6 have previously been shown to
increase the
risk of heart disease and type 2 diabetes.
According to the World Health Organization, more than 21 million people worldwide suffer from
schizophrenia, a severe psychiatric disorder that can cause delusions and hallucinations and lead to
increased risk of suicide.
Led by Brenda Penninx, PhD, of the VU University Medical Center in Amsterdam, the Netherlands, the study found that patients with an early age at onset and higher symptom severity have an
increased genetic
risk for MDD, bipolar disorder and
schizophrenia.
The second locus significantly correlated with severe CCD was on chromosome 11, the same chromosome that contains a gene thought to
increase the
risk of
schizophrenia in humans.
They also discovered that compared with healthy controls, patients with first episode
schizophrenia had higher levels of insulin and
increased levels of insulin resistance, again supporting the notion that this group are at higher
risk of developing diabetes.
Using an independent group of 1602 MDD patients and 1390 control participants from the RADIANT - UK study, the researchers also replicated their finding that patients with a high number of DSM symptoms have
increased genetic
risk for
schizophrenia.
This suggests that the results were not wholly driven by differences in lifestyle factors or ethnicity between the two groups, and may therefore point towards
schizophrenia's direct role in
increasing risk of diabetes.
According to the researchers, the probable disruption of normal neurological development in childhood
increased the
risk of developing
schizophrenia.
The results of a comprehensive study conducted at the University of Haifa have shown that Holocaust survivors are at
increased risk of developing
schizophrenia.
Prof. Stephen Levine, who undertook the study, explains: «The exposure to protracted multiple maximal physical, social and psychological adversities of the Holocaust
increased the
risk of survivors developing
schizophrenia.»
The
risk of
schizophrenia to someone who carries one of these markers is
increased by as little as one - tenth of a percent.
Hearing voices at age 11 indicates a 16-fold
increased risk of
schizophrenia — but the overwhelming majority of these kids will never develop it.
The children in the study have 22q11.2 deletion syndrome, which is linked to a 25-fold
increase in the
risk of developing a psychotic condition such as
schizophrenia.
Research has established that people with confirmed psychotic illnesses such as
schizophrenia are at
increased risk of cardio - metabolic disease.
«The
risk for
schizophrenia increases 2-fold when a father is over 45 years of age, and the
risk for autism
increases 2 -5-fold.
A new study could explain how migrating to another country
increases a person's
risk of developing
schizophrenia, by altering brain chemistry.
Researchers have identified a gene that
increases the
risk of
schizophrenia, and they say they have a plausible theory as to how this gene may cause the devastating mental illness.
Low birth weight and preterm birth appear to
increase the
risk of
schizophrenia among individuals with a genetic condition called the 22q11.2 deletion syndrome, a new study from the Centre for Addiction and Mental Health (CAMH) shows.
The study may explain, among other things, how the mother's infection with the cytomegalovirus (CMV) during pregnancy, which affects her own and her fetus's immune system,
increases the
risk that her offspring will develop autism or
schizophrenia, sometimes years later.
Though these findings have been obtained in mice, the scientists hypothesize that disrupted coordination between the development of the microglia and that of the brain contributes to an
increased risk of such neurodevelopmental disorders as autism and
schizophrenia in human beings.
A rare gene variant discovered by UCL (University College London) scientists is associated with an
increased risk of developing
schizophrenia, bipolar disorder and alcoholism, confirms new research.
It found that people with the variant of the GRM3 gene, thought to be important in brain signalling, were at
increased risk of developing bipolar disorder,
schizophrenia and alcohol dependence.
Dr. Paus, a prominent researcher and pioneer in the field of population neuroscience, strongly cautioned that more research is needed to determine whether lower cortical thickness actually
increases the probability of
schizophrenia in at -
risk males later in life.
What was most frightening to me, as someone with mental illness in the family, is that older fatherhood was also associated with an
increased risk of
schizophrenia.
In all these studies, researchers took a close look at whether there was something about the older fathers — unrelated to age — that
increased the
risk of
schizophrenia in their children.
These imprinting defects may give rise to the
increased risk of
schizophrenia, autism and perhaps some of the other ailments related to paternal age.
For every 1 mg / L
increase in maternal C - reactive protein, the
risk of
schizophrenia increased by 28 %.
Results showed that a higher maternal nicotine level in the mother's blood was associated with an
increased risk of
schizophrenia among their offspring.
A study by researchers at Columbia University's Mailman School of Public Health, Columbia University Medical Center (CUMC), New York State Psychiatric Institute and colleagues in Finland reports an association between smoking during pregnancy and
increased risk for
schizophrenia in children.
«This is the first time that this association has been demonstrated, indicating that an infection or
increased inflammation during pregnancy could
increase the
risk of
schizophrenia in the offspring,» said Alan Brown, MD, MPH, professor of Epidemiology and Psychiatry and senior author.
To the extent that the
increased inflammation is due to infection, this work may suggest that approaches aimed at preventing infection may have the potential to reduce
risk of
schizophrenia.»
Many of the genetic variations that
increase risk for
schizophrenia are rare, making it difficult to study their role in the disease.
Similarly, cocaine abusers (17, 18) and alcoholics (19, 20), but not marijuana abusers (16), show attenuated DA
increases in striatum when challenged with a stimulant drug, although marijuana abusers with comorbid
schizophrenia or
risk for
schizophrenia showed blunted DA
increases to stimulants (21) and to stress (22).
For instance, one genetic variant might both predispose people to smoking and
increase the
risk of
schizophrenia, without one causing the other.
Interestingly, an imaging study comparing DA
increases using BPND and 4 - propyl -9-hydroxynaphthoxazine -LRB-[11C] PHNO)(radiotracer with > 20-fold higher affinity for D3 over D2 receptors, and presumably more sensitive to competition with endogenous DA)(63, 64) in response to a stressor in individuals at high
risk for
schizophrenia showed that those who abused marijuana had a blunted response, consistent with decreased DA signaling (22).
Other research has shown that long - term use of cannabis
increases adolescent drug users»
risk for certain psychiatric and neurological disorders, such as
schizophrenia.
According to a scientist from Perth, Australia (where one of the first studies of mothers with
schizophrenia and their offspring has recently been completed), studies have identified obstetric events that can
increase the
risk of
schizophrenia in the offspring by 2 - to 7-fold.