Sentences with phrase «increase tumor response»

Not exact matches

Dr. Joaquín Espinosa is enthusiastic about the results of his study, «The constant activation of the Interferon response could explain many aspects of Down syndrome, such as cognitive deficit, stunted growth, increased prevalence of autoimmune disorders, high risk of Alzheimer's disease, and protection against solid tumors.»

Half of the patients that could be evaluated showed big increases in the numbers of T - cells specifically reactive to tumor material, indicating a good response to vaccination.

This blood vessel normalization results in an increased barrier function on the one hand — thereby blocking cancer cell dissemination and metastasis - and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.

Doctors at the University of Arizona Cancer Center at St. Joseph's Hospital and Medical Center in Phoenix reported today in Lancet Oncology that a new treatment for ovarian cancer can improve response rates (increase the rate of tumor shrinkage) and prolong the time until cancers recur.

The Cancer Vaccine Collaborative is working on treatments that target multiple cancer antigens, which should trigger a more aggressive immune response and increase the odds of defeating tumors.

In this study, we examined the effectiveness of a vaccination targeting tumors that produced IL - 15 and its cell surface receptor called IL - 15R - alpha -LRB--RRB- and examined their ability to up - regulate (or increase) immune responses to tumor antigens,» Morris says.

Their results demonstrate that specific rhoptry and dense granule effector proteins that T. gondii secretes before and after host cell invasion, respectively, control the development of an effective host antitumor response, and increase the survival of mice with ovarian tumors.

Mechanistic studies showed that IFN increases antitumor immune responses by enhancing antigen presentation to T cells by dendritic cells present in the tumor microenvironment.

They promote the growth of cancerous cells by releasing growth factors and increasing the response of certain proteins that regulate tumor cell development (oncoproteins).

«Immune checkpoint inhibitors amplify T - cell responses and are currently being tested in the clinic to increase T - cell - mediated tumor killing,» says Pedro Lowenstein, M.D., Ph.D., co-senior author.

However, an overactive stimulation of mTOR in response to nutrients and growth factors — metabolic processes that are crucial in tumor biology — leads to an increase in cell growth and proliferation.

For nearly 20 years, doctors have used cyclosporine to dull the immune response, which would otherwise reject a transplant — a strategy that carries with it a 100-fold increase in tumor risk among these patients compared to healthy individuals.

We've found through trials that a complete response is difficult to achieve, but patients whose tumors shrink by 30 percent can experience a major increase in quality of life.

Other research is investigating whether agonist reagents that can signal various immune cells such as T cells, dendritic cells, or NK cells, through the TNF family receptors OX40, 4 - 1BB, HVEM, or LTβR can be used to increase natural immune responses to viruses or tumors that might lead to new strategies for vaccination.

Characterizing the molecular pathways regulating genomic stability at damaged replication forks in HR - deficient cancers will increase our understanding of the cellular response to replicative stress, and in the same time, potentially allow the identification of new predictors (biomarkers) of chemo - sensitivity / resistance in these tumors (Figure 2B).

Although vaccination induces an inflammatory response during pregnancy, the magnitude and the duration of response is much lower and shorter, respectively, for influenza vaccination than viral infection.27 Like infection, influenza vaccination during pregnancy has been reported to induce a transient increase in the levels of a number of proinflammatory cytokines, including interleukin 6, tumor necrosis factor α, and C - reactive protein.27 - 30 Studies on mice found an association between high interleukin - 6 levels during pregnancy and abnormal behavior and brain structure.19 However, in epidemiological studies, associations between maternal cytokine levels and ASD have been mixed.

Important features of XMRV biology include (1) tropism for a variety of cell lines, including prostate cancer DU145 and LNCaP cells [27], [43], [48], and human neural cell types [57], (2) adaptations that promote growth in prostate epithelium and human - derived prostate cancer cell lines including an androgen response element in the promoter region [58] and downregulation of APOBEC3G [59], and (3) cellular effects with potential oncogenic properties including increased tumor aggressiveness mediated by downregulation of p27 [60] and differential regulation of several microRNAs [61].

This is supported by recently published data in the New England Journal of Medicine (21), where patients with triple - negative breast cancer were seen to show increased complete pathologic response to bevacizumab treatment, with no detectable tumor at primary or metastatic sites, whereas no improvement was observed in hormone receptor — positive cases.

G100 was well tolerated, with no related Grade 3/4 AEs in all three dose levels tested, and tumor biopsies showed increased inflammatory responses and T cell infiltrates in abscopal, non-treated tumors.

Enhanced cortisol increase upon awakening is associated with greater pain ratings but not salivary cortisol or soluble tumor necrosis factor - α receptor II responses to acute pain.

Response: Bailey continued to have little evidence of pain even in face of increasing tumor size.

Ki67 measures were also conducted: in humans, Ki67 indices are usually associated with increased tumor grade and poor response to therapy (5).

However, in some tumors increased frequency of Tregs can impair protective anti-tumor immune responses.