Sentences with phrase «increase tumorigenic»

The prevailing theory of cancer progression — that it's driven by the accumulation of genetic mutations that increase tumorigenic «fitness» — holds true for the early stages of cancer progression, but metastases seem to find new ways to increase their fitness, McDonald said.

The current research suggests that pancreatic cancer cells that spread to organs that receive a blood supply rich in glucose and other nutrients, such as the liver and lungs, acquire metabolic adaptations to use these «natural resources» to increase their tumorigenic fitness.

Not exact matches

Together, our results reinforce the idea that EMT and stem cell factors work cooperatively in highly tumorigenic cancer subpopulations and raise interesting questions about their contribution to the increased metastatic capability observed in the cycling hypoxia - selected subpopulation.

Also, increased NAMPT expression is reported in some malignancies, calling into question whether increasing NAD + might support aspects of the tumorigenic process [235].