Masters et al. discuss the often overlooked contribution of the stromal microenvironment as an extrinsic factor to immunosenescence and
inflammation.12 Accumulation of senescent stromal cells which demonstrate the senescent associated secretory phenotype (SAPS), may alter tissue structure and function, and
increase local
inflammation.13 The impact of altered lymphoid stromal microenvironment may be
widespread and include altered haematopoiesis, reduced lymphatic flow and disrupted secondary lymphoid organisation, which consequently will alter antigen transportation and presentation to T cells.12
A study published in the October 2012 issue of the «International Journal of Biochemistry and Cell Biology» found that polyphenol antioxidants in coffee and tea prevent oxidation of fats, a process that promotes
widespread inflammation and can
increase risk of heart disease and diabetes.