Sentences with phrase «increased apoptosis»

This results in increased apoptosis in drug resistance liver cancer cells.

It was demonstrated in this study where combining UVB radiation with curcumin led to massively increased apoptosis (programmed cell death) compared to UVB alone.

Another study published in the journal Cancer Biotherapy and Biopharmaceuticals found that FWGE in conjunction with the ER + breast cancer chemotherapy drug Tamoxifen «significantly increased apoptosis already 24 hours after starting treatment.»

Further, increased SF content was associated with reduced inflammation, increased apoptosis, and decreased proliferation.

Microinjection manipulation resulted in the increased apoptosis of spermatocytes in testes from intracytoplasmic sperm injection (ICSI) derived mice

STAT6 - null phenotype lymphocytes derived from imflammatory bowel disease patients show increased apoptosis (Galka et al., 2004).

Our findings confirm previously published data as treatment of Karpas 299 and SU - DHL1 cells with increasing concentrations of LY294002 led to decreased cell viability and increased apoptosis, as determined by Annexin V staining, in a dose - dependent manner (Supplementary Fig.

As reported previously, inhibition of PI3K resulted in increased apoptosis of ALCL cells (5).

Enhanced monocyte binding to human cytomegalovirus - infected syncytiotrophoblast results in increased apoptosis via the release of tumour necrosis factor alpha.

Across multiple triple - negative breast cancer subtypes, inhibiting the androgen receptor greatly increased apoptosis (programmed cell death), inhibited growth and increased necrosis by 60 percent in animal models.

In addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damage.

Overexpression of Cox - 2 in Human Osteosarcoma Cells Decreases Proliferation and Increases Apoptosis

Our data raise the possibility that inhibition of ABL kinases can increase apoptosis of breast cancer cells and block osteoclast activation, which is required for osteolytic metastasis.

Studies suggest that flax may reduce the growth of abnormal cells and increase apoptosis (programmed death) of cancer cells in breast tissue (1, 2, 3).

Not exact matches

Giving the mice antibiotics helped gemcitabine kill tumor cells, increasing the number of tumor cells going through a type of cell death called apoptosis from about 15 percent to 60 percent or more.

Gradual increase of p53 levels activates apoptosis promoting protein Bak on the surface of the mitochondria making these cells vulnerable to death.

At the IMCB, headed by Professor Chris Tan, we were able to increase our productivity through closer collaborations and interactions with scientists studying apoptosis and cell regulation.

However, in developing brain cells, the researchers found TLR3 activation also influences 41 genes that add up to a double whammy in this model — diminished stem cell differentiation into brain cells and increased cell suicide, a carefully controlled process known as apoptosis.

In contrast, the growth of clones derived from progenitor cells becomes checked by increasing levels of apoptosis, leading to the formation of benign lesions.

Replication increases β - cell vulnerability to human islet amyloid polypeptide - induced apoptosis

Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8 % O2 for 3 h) including several known hypoxia inducible genes such as MAP kinase phosphatase - 1 (MKP - 1), several HIF - 1 target genes including VEGF and GLUT - 1, genes implicated in apoptosis, signal transduction molecules, and transcription factors.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

IG20 (MADD splice variant - 5), a proapoptotic protein, interacts with DR4 / DR5 and enhances TRAIL - induced apoptosis by increasing recruitment of FADD and caspase - 8 to the DISC.

Expression of sulfotransferase isoform 1A1 (SULT1A1) in breast cancer cells significantly increases 4 - hydroxytamoxifen - induced apoptosis.

In addition, consistent with past studies, AAV2 - infected cancer cells produced more Ki - 67, an immunity system activating protein and c - Myc, a protein that helps both to increase cell growth and induce apoptosis.

Radiation - induced thymic lymphomas in p21 - null mice exhibit increased levels of constitutive apoptosis.

Injections of iPSC - EPCs did not however have significant effect on tumor growth or on overall survival, but transducing cells with a baculovirus expressing CD40L, a member of the TNF gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis, increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L carried by the EPCs (See figure).

Stem cells affect the infarcted myocardium via neovascularization, reduction of apoptosis and paracrine effect, they are able to increase myocardial perfusion, inhibit synthesis of pro-inflammatory cytokines (IL6 and TNFα) and promote expression of anti-inflammatory cytokines (IL10) minimizing the necrosis damage caused by local inflammatory reaction.

Cell viability and apoptosis following treatment of Karpas 299 and SU - DHL1 cells with increasing concentrations of rapamycin and mTOR silencing (siRNA) were assessed using trypan blue exclusion assay and Annexin V staining, respectively.

Rapamycin treatment also showed a concentration - dependent increase in Annexin V — positive cells, indicating that cell death was secondary to apoptosis (Fig. 6A).

Previously, we have shown that flies under - expressing the two mitochondrial peroxiredoxins (Prxs), dPrx3 and dPrx5, display increases in tissue - specific apoptosis and dramatically shortened life span, associated with a redox crisis, manifested as changes in GSH: GSSG and accumulation of protein mixed disulfides.

TRAIL - enhanced apoptosis as measured by cleavage of caspase - 3 (Fig. 4I), and knockdown of ABL kinases increased the sensitivity of 1833 breast cancer cells to the proapoptotic effects of TRAIL (Fig. 4, G to I).

Microarray profiling identified STAT6 as one of the proteins whose expression was increased in apoptosis - resistant cells (Gagarin et al., 2005).

Increase in apoptosis following down - regulation of tubular β - catenin signaling in chronic kidney disease 2016 September 2 Tags: Immunohistochemistry, Metabolism

Manuscripts that increase our understanding of the processes through which stem cells and progenitors differentiate into committed progeny, the commitment cell death programs such as apoptosis and necrosis, aging, and the transition between proliferation and cell cycle arrest are welcome.

TRPV1: Contribution to Retinal Ganglion Cell Apoptosis and Increased Intracellular Ca2 + with Exposure to Hydrostatic Pressure Sappington, R.M., Sidorova, T., Long, D.J. & Calkins, D.J. (2009) Investigative Ophthalmology & Visual Science, 50:717 - 28.

By examining this damage, it was found that the Bax / Bcl2 ratio, a parameter that is indicative of the apoptosis status [21], was increased in the testes of IVC - derived males, suggesting that there were a high number of apoptotic cells in that tissue, and this was confirmed by TUNEL assay.

As we did not observe any proliferation or apoptosis differences in the non-CSC or the CSC - enriched fraction in ER - α — positive cell lines, we hypothesize that either self - renewal symmetry is altered or cells are caused to dedifferentiate resulting in the increased CSC numbers seen.

Many mechanisms of MDR have been described, such as the overexpression of MDR1 (also known as P - glycoprotein or ABCB1) or other ATP - dependent transporters that pump drugs out of the cancer cells, amplification of drug - inactivating enzymes, mutations or modifications of drug targets, alterations in DNA repair machinery, and increased resistance to apoptosis (1 — 3).

Enhanced amyloidogenic processing of APP by the ß - site APP cleaving enzyme (BACE) and the γ - secretase complex and reduced clearance lead to increased intracellular levels of soluble oligomeric Aß, resulting in cellular dysfunction comprising e.g., synaptic failure, mitochondrial dysfunction, enhanced oxidative stress, neurotransmitter and neurotrophin depletion, inflammation, and apoptosis which is reflected in patients as clinical symptoms such as cognitive deficits [2, 3].

Akt stimulates glucose uptake, glycogen synthesis, and protein synthesis via Akt / mTOR and Akt / GSK -3 β signaling networks and inhibits apoptosis and protein degradation in skeletal muscle by inactivating FoxO transcription factors leading to increased lean mass.

Although a non - essential amino acid in normal cells, the demand for glutamine is dramatically increased throughout malignant transformation to support increased metabolic demands; namely, provision of catabolic substrates for ATP production and anabolic substrates for macromolecule biosynthesis.The intracellular glutamine pool is also critical for sustained activation of mTORC1 signalling, a master regulator of cell growth and protein translation, as well as prevention of apoptosis

Duntas (2015) articulates, «In susceptible individuals, iodine excess increases intra-thyroid infiltrating Th17 cells and inhibits T regulatory (Treg) cells development, while it triggers an abnormal expression of tumor necrosis factor - related apoptosis - inducing ligand (TRAIL) in thyrocytes, thus inducing apoptosis and parenchymal destruction» (31, p. 721).

Abnormal Krebs cycle and / or oxidative phosphorylation cause (s) not only glucose hypometabolism but also the increased generation of reactive oxygen species (ROS), oxidative damage, and programmed cell death such as apoptosis.

Because we have come to expect that autophagy and apoptosis will increase during fasting does the increased loss of N during the first days of fasting result in significant reduction in muscular functionality or is it a result confounded by multiple mechanisms?

The authors suggest a mechanism whereby HMB inhibits inflammation and muscle apoptosis in these populations, as well as improving protein synthesis and decreasing protein degradation, which results in increasing lean mass.

Additional research shows that Lactobacillus helveticus and Bifidobacterium longum added to animal drinking water can increase nerve cell resiliency and reduce apoptosis during conditions of experimental physiological stress [92].

Resistant starch has been investigated in the past for its effects on bowel health (pH, epithelial thickness, and apoptosis of colorectal cancer cells); reduction in postprandial glycemia; increased insulin sensitivity; and effects on the gut microbiome.

In the same way, whereas NR supplementation increased muscle stem cell number in aged mice, thereby enhancing mitochondrial function and muscle strength, it reduced the expression of cell senescence and apoptosis markers [233]; the state of senescence is important to protect against carcinogenesis [234].

There is increasing evidence that SIRT1 is profoundly involved in cancer, apoptosis, and neurodegenerative diseases.