Sentences with phrase «increased by insulin»

Vascular tone, how much the blood vessels are constricted in increased by insulin by increased intracellular calcium and activation of the sympathetic nervous system.

Not exact matches

As lawmakers and the public scrutinize dramatic price increases for other old drugs — most recently with the Mylan - owned EpiPen, which saw its cost go up by 500 % in the past nine years — the next flash point may be insulin, a drug both ubiquitous and complicated.

Along with Novo Nordisk and Sanofi, Lilly is one of the three big insulin makers under investigation by state attorneys general for price increases that the investigators believe are suspiciously similar in size and timing.

Pomegranates have been shown to be beneficial for Type 2 Diabetics in some studies, by increasing insulin secretion and assisting in weight loss.

Evidence shows that gojis exhibit significant hypoglycemic effects and insulin - sensitizing activity by increasing glucose responsiveness.

Atkins rejects the advice of the food pyramid, instead asserting that the tremendous increase in refined carbohydrates is responsible for the rise in metabolic disorders of the 20th century, and that the focus on the detrimental effects of dietary fat has actually contributed to the obesity problem by increasing the proportion of insulin - inducing foods in the diet.

Try to make your diet high in protein by following a diet plan like The Dukan Diet which will help counteract the threat of increased levels of insulin in your body as well as help you lose weight.

Rapamycin, by contrast, allowed a buildup of fatty acids and eventually an increase in insulin resistance, which in humans can lead to diabetes.

Witness Avandia, a popular drug available since 1999 that lowers blood glucose by making cells more receptive to insulin — but that also, according to a report published in the New England Journal of Medicine in May, increases the risk of heart attack.

In mice that are given a high - fat diet, an increased production of the enzyme DPP4 * by the liver promotes an increase in body fat, the development of fatty liver disease and insulin resistance.

In mice, this form of lipodystrophy was also characterized by «whitening» of brown fat cells, a loss of white fat, and signs of metabolic syndrome, including insulin resistance, fat tissue inflammation, dyslipidemia (elevated cholesterol and fat), increased resting energy use, and increased markers of cardiovascular disease.

In the vernacular of the science, calorie restriction appears to increase life span and health span at least in part by «reducing signaling in the insulin / IGF pathway.»

Whole - body vibration and exercise reduced insulin levels by similar amounts in the mice and increased their responsiveness to the hormone, the scientists report online today in Endocrinology.

«Under conditions when the liver is not stimulated by insulin, increased glucose output from the liver means the liver isn't responding to signals telling it to shut down glucose production,» Belury said.

Now, experiments with rats and mice have shown that insulin increases dopamine levels by 20 % to 55 % in the striatal region, a brain area associated with pleasure and decision - making, according to a study published on 27 October in Nature Communications.

These subjects developed increased fasting insulin secretion and insulin resistance, increased glucose release by the liver which produced high blood sugar, and dramatically lowered fat oxidation that contributes to obesity.

«We know that amlexanox works to reverse obesity and insulin resistance in part by resolving chronic inflammation and increasing energy expenditure, but that's not the whole story of the drug's effects,» said Shannon Reilly, first author of the study.

These receptors determine the differentiation of cell function and may increase the ability to produce insulin in response to glucose by beta cells.

These trends may be explained in part by the yo - yo effects that high glycemic - index carbohydrates have on blood glucose, which can stimulate fat production and inflammation, increase overall caloric intake and lower insulin sensitivity, says David Ludwig, director of the obesity program at Children's Hospital Boston.

«By reducing the gene expression, the muscle's insulin sensitivity was increased,» says Cajsa Davegårdh.

Throughout the day, the pancreas regulates the body's blood sugar levels, responding to an increase in glucose after a meal by secreting insulin, which helps cells take up the sugar.

In contrast, in mice with normal immune systems, emulsifiers induced low - grade or mild intestinal inflammation and metabolic syndrome, characterized by increased levels of food consumption, obesity, hyperglycemia and insulin resistance.

Atkins rejects the advice of the food pyramid, instead asserting that the tremendous increase in refined carbohydrates is responsible for the rise in metabolic disorders of the 20th century, and that the focus on the detrimental effects of dietary fat has actually contributed to the obesity problem by increasing the proportion of insulin - inducing foods in the diet.

Insulin resistance increased by 17 % for every 10.6 µg / m3 (2 standard deviations [SDs] from the mean) increase in ambient nitrogen dioxide (NO2) and 19 % for every 6 µg / m3 (2 SDs) increase in particulate matter of up to 10 μm in diameter.

Thus, astrocytic insulin signaling plays an important role in dopaminergic signaling, providing a potential mechanism by which astrocytic insulin action may contribute to increased rates of depression in people with diabetes, obesity and other insulin resistant states.

The study provides evidence for «potential mechanisms by which sleep restriction may be associated with insulin resistance and increased type 2 diabetes risk,» the authors conclude.

Insulin - like growth factor - I prevents the accumulation of autophagic vesicles and cell death in Purkinje neurons by increasing the rate of autophagosome - to - lysosome fusion and degradation.

When blood glucose levels are high, hepatocytes respond to insulin by increasing glycogen storage, decreasing gluconeogenesis, and decreasing glycogenolysis.

IGF prevents frailty by increasing skeletal muscle mass (sarcopenia), sex drive (infertility), brain thymus (immunosenescence, centenarians maintain a strong immune system), skeletal bone mineralization and marrow stem cell formation (osteoporosis and immune system by bone marrow immune cells working in tandem with thymus and lymphs nodes), I understand that diabetes, an accelerated aging phenotype, is insulin IGF and blood glucose driven.

After four nights of sleep restriction, the volunteers» insulin sensitivity decreased by 23 percent and their diabetes risk increased by 16 percent.

Acute insulin stimulation significantly increased GS activity at 0.1 mmol / l in both diabetic (P < 0.0001) and control (P < 0.0001) cultures; however, GS activity at 10 mmol / l was unaffected by acute insulin stimulation in both culture types (P > 0.55 in diabetic and control cultures).

IFG is characterized by increased hepatic glucose output and impaired early insulin secretion, whereas IGT is primarily due to peripheral insulin resistance (82).

Myotubes were precultured in increasing insulin concentrations for 4 days and subsequently stimulated acutely by insulin.

Metabolic disorders related to obesity - associated insulin resistance have been characterized by an increased influx of inflammatory cells into adipose tissue (41).

Acute insulin stimulation increased glucose transport by 21 % in control cultures precultured at 1 pmol / l insulin, but at higher insulin concentrations we could not detect an effect of insulin on glucose uptake.

As a new finding, we describe here that impaired GS activity in cell cultures established from type 2 diabetic subjects can be compensated for by increasing insulin concentrations in a dose - dependent manner.

«In our model, stress conditions, such as a genetic variant or insulin resistance or a high - fat diet, lead to increased availability of the tribbles protein by as yet poorly understood mechanisms,» says Dr. Kulkarni, who is also an Assistant Professor of Medicine at Harvard Medical School.

Reducing the insulin receptors from one set of mice did not significantly impair their glucose metabolism, says Rask - Madsen — certainly not enough to make the animals overtly insulin resistant — but it did increase the amount of circulating insulin by reducing its removal from the blood.

By eight to twelve weeks following transplantation, the BAT - transplanted mice fed a normal diet showed improved glucose tolerance, increased insulin sensitivity, lower body weights and decreased fat mass.

In one set of experiments, when the scientists boosted insulin resistance by giving mice a compound that cuts insulin signaling, they saw increased expression of several markers of aging in beta cells.

The new findings build on a 2010 study conducted by Rask - Madsen, which found that insulin resistance only in endothelial cells is sufficient to increase susceptibility to atherosclerosis.

In this condition, vascular cells could become dysfunctional because of hyperinsulinemia or because vascular cells themselves are insulin resistant, which is caused by increased insulin production from pancreatic beta cells as a compensatory mechanism to overcome insulin resistance.

It has been shown to increase insulin sensitivity and decrease plasma glucose by increasing tissue fat oxidation.

Blood glucose levels are regulated by the pancreas» beta cells, which secrete insulin that signals to the body to reduce blood glucose levels; and by alpha cells, which secrete glucagon that signals to the body to increase blood glucose levels.

By contrast, the sensitivity of the maternal liver to insulin was increased, which reduces glucose production during pregnancy.

Systemically, the antibody treatment increased insulin sensitivity, as demonstrated by lowered blood glucose, and improved glucose utilization by tissues.

On the other hand, increased levels of insulin after your workout will help the anabolic process by transporting glycogen to your muscle cells.

Researchers have found that while short - term psychological stress can actually be good for you, chronic stress suppresses your immune system and could increase your risk of developing type 2 diabetes by altering your insulin needs.

When taken after exercise, creatine will boost muscle creatine stores and promote greater protein synthesis during recovery by increasing the amount of water taken up by muscle cells and increasing the release of the anabolic hormone insulin - like growth factor - 1 (IGF - 1).

Although the increased presence of insulin stimulates body fat build up, this hormone also participates in muscle growth, by providing an anabolic effect.