Sentences with phrase «increased cell expression»

So the team also injected the rodents with a virus that increased cell expression of the channel just within that brain area.

Not exact matches

Capsaicin induced a further induction of TPA - increased COX - 2 expression in EGFR / WT cells, but not in EGFR / KO cells.

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

This study built on previous research from the Sundrud lab, which showed that when TH17 cells entered the intestine in human tissue samples, they increased the expression of a gene called MDR1.

Between 10 days and three months, the cells exposed to smoke had a two - to four-fold increase in the amount of an enzyme called EZH2, which works to dampen the expression of genes.

Silencing five genes whose expression negatively correlated with caspase activity significantly increased cancer cells» sensitivity to radiation (Genome Research, DOI: 10.1101 / gr.122044.111).

Dr. Llovet and colleagues demonstrated that the expression of mutant IDH in the adult liver of genetically engineered mice impairs liver cell development and liver regeneration — a process in which the liver responds to injury — and increases the number of cells to form a tumor.

Upon H1N1 viral infection, the cells showed an increase in MHC class I (green) and p53 (red) expression.

Sure enough, plant root cells that harbor fungal arbuscules increase their expression of genes involved in producing such lipids by 3000-fold.

The increased expression cells are called «Runx2 knock - in» cells, and the decreased expression cells are called «Runx2 knock - down» cells.

They found similar changes in gene expression in the same genes with increased activity of glucose transporters in both the stem cells and the fat cells, Sen noted.

«Severe allergic asthma with neutrophils is due to increased IL - 17A expression produced by T - helper 17 cells,» explained Ryffel.

Kasper says that these results suggested a pathway: without exposure to certain microbes, methylation increases CXCL16 expression, which ultimately increases iNKT cell numbers and inflammation.

Strikingly, sustaining Pax6 expression in mouse basal progenitors increased their capacity to undergo multiple rounds of cell division, as typically observed in primates.

Heat shock proteins (HSP) are a group of proteins the expression of which is increased when the cells are exposed to elevated temperatures.

Increasing the expression of one of the proteins, SIX3, in the insulin - producing cells isolated from younger donors enhanced their ability to respond efficiently to rising glucose levels.

The results showed that, when applied, a long - term inhibition of Rho - kinase signaling increased the expressions of chondrocyte - specific genes and differentiation markers in human chondrosarcoma 2/8 cells.

The good news about the complex interconnectivity is that the scientists also were able to find a potential future point of intervention: When they gave a drug that increased AMPA receptor expression on the cell surface, the spines assumed a more healthy, mature state.

The Rho - kinase inhibition stimuli under low oxygen conditions (of 5 percent oxygen atmosphere), which is a condition corresponding to conditions in the body's cartilage, produced a more effective increase in chondrocyte - specific gene expression and synthesis of extracellular matrix components by HCS - 2 / 8 cells.

«The genes which these miRNAs regulate also had increased levels, indicating that these gene expression, indicating that these gene products were likely targeted for storage and for possible future use within the brain cell, rather than for destruction.

Increased SQLE expression promotes the biosynthesis of cholesteryl ester, which induces NAFLD - HCC cell growth.

The researchers already had some information about molecules that increase in expression on the cortical side of the cell, including one called CDC42.

The researchers also looked at the gene expression of skin cells from people with psoriasis and found decreased expression of the genes involved in pigmentation signaling, correlated with increased amounts of IL - 17 and TNF.

Bone marrow mesenchymal stem cells and bone cells from the skulls of Cbf - beta - deficient mice showed increased expression of adipocyte genes.

When we experimentally increased the expression of the microRNAs in model nerve cells designed to replicate the conditions of HD, the cells lived longer, indicating that these miRNAs may promote cell survival,» explained lead author Richard Myers, PhD, professor of neurology at BUSM.

Dr. Qu said not only did disc height increase, but stem cell transplant also increased disc water content and improved appropriate gene expression.

Results show that one night of partial sleep deprivation activates gene expression patterns in peripheral blood mononuclear cells (PBMCs) consistent with increasing accumulation of damage that initiates cell cycle arrest and increases susceptibility to senescence.

In particular, Nguyen and Ehrenstein discovered that adalimumab increases the expression of TNF on the surface of patient monocytes and promotes the association of these TNF molecules with receptor proteins on the surface of regulatory T cells.

They found higher levels of JAK1 in resistant tumors, which caused increased expression of epidermal growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes cell proliferation.

«Because TIA - 1 is known to suppress COX - 2 expression in other cells, we reasoned that the inactivation of the TIA - 1 gene would increase COX - 2 expression in neurons and, consequently, would increase resistance to acute seizures,» he continues.

Increasing expression of a chemical cytokine called LIGHT in mice with colon cancer activated the immune system's natural cancer - killing T - cells and caused primary tumors and metastatic tumors in the liver to shrink.

They confirmed low levels of miR - 184 expression in human glioma tissue samples and cultured cell lines as well as an increase in the expression of SND1 compared to normal brain tissue.

The team narrowed down the approximately 1000 microRNAs to a handful that induced strong fluorescence in the system, and then reduced these to two that they confirmed could increase E-cadherin expression in pancreatic cancer cells.

Through a variety of preclinical experiments, the team demonstrated that increasing the expression of miR - 184 slows the growth and invasive characteristics of glioma cells through direct regulation of SND1.

In preclinical experiments using human prostate cancer cell lines, Fu's team showed that increased PLK1 expression activated an oncogene known as c - RAF, which has previously been shown to play a role in regulating cell growth and division.

Its expression in these cells increases in response to TBI, the researchers said.

They also show increased expression of the estrogen receptor alpha [ER +] gene that drives cell division,» says Koshy.

The investigators also measured gene expression of postvaccinated cervical cells in three of the patients and found increased expression of several genes (CXCR3, Tbet and IFNβ) associated with activation of the immune system.

Surprisingly, Peyer's patch B cells have an increased level of GARP expression, likely needed to regulate the activation of these B cells.

Loss of the PBRM1 gene function caused the cancer cells to have increased expression of other genes, including gene pathway known as IL6 / JAK - STAT 3, which are involved in immune system stimulation.

The beneficial responses were associated with an increase in systemic dendritic cells, which in turn increased the expression of interleukin 12 (IL - 12), which sustained expansion and anti-tumor effects of transferred T cells.

«This study for the first time shows increased expression of IL - 33 in AMD and further demonstrates a role for glia - derived IL - 33 in the accumulation of myeloid cells in the outer retina, loss of photoreceptors, and functional impairment of the retina in preclinical models of retina stress,» the authors note.

They then asked why biglycan expression was increased in the endothelial cells, and found that the promoter region of the gene was de-methylated, meaning the gene was switched on.

Unlike most biomarkers for cancer, DDX3 mRNA expression only increased slightly in the exposed breast cells, but the corresponding proteins levels were significantly higher.

This was associated with increased intestinal and pulmonary expression of the chemokine ligand CXCL16, which was associated with increased mucosal iNKT cells.

The cells I had were ovine mammary epithelial cells: we were looking to increase expression of proteins in milk.

Piert adds, «Furthermore, PAT expression increases with cell proliferation.

Last, CD34 + cells from T1D patients were pharmacologically treated to increase PD - L1 expression, and these modulated cells demonstrated an enhanced immunosuppressive effect in vitro.

The increase in the expression of transporters in germ cells could potentially result in earlier stages of spermatogenic cells which become more resistant to the deprivation of RAR signaling from the RAR antagonist.

Notably, the brains of treated fish showed increased expression of genes involved in making ferritin, a protein that stores and transports iron inside cells.