Sentences with phrase «increased cell survival»

The mechanism for this markedly enhanced effect appears to be increased cell survival and retention.

«One of the major and immediate downstream effects of myc activation is a dramatic increase in the capacity of affected cells to make protein,» Ruggero said «This, in turn, leads to increased cell survival and proliferation, and to unstable genomes that foster additional mutations that turn these abnormal cells into tumor cells.»

IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF - 7 human breast cancer cells.

Because the aggressive reaction of the immune system somewhat mimics the way the body reacts to transplanted organs, the researchers wondered if common antirejection medications would increase cell survival.

Not exact matches

Interestingly, none of the opponents of embryonic stem cell research have called for research programs that might increase the odds of embryo survival.

White blood cell count increases with vigorous crying, suggesting the body is preparing a survival response.

«In animal studies, exercise has been shown to specifically affect the hippocampus, significantly increasing the growth of new neurons and cell survival, enhancing memory and learning, and increasing molecules that are involved in the plasticity of the brain,» Chaddock said.

Again, using mouse models of glioblastoma — this time created from brain tumor cells that were resistant to the herpes virus — the therapy led to increased animal survival.

Furthermore, when healthy neurons in a dish were treated with serum from the patients and antibodies against leiomodin - 1, they did not survive, but removing the antibodies increased brain cell survival.

In the study, exosomes, which are generated by all cells and are naturally present in blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in disease suppression and increased overall survival in mouse models.

The study «Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation» is published in the journal Scientific Reports.

These include a plant - produced chemical called resveratrol, which spurs cells to increase production of sirtuins, the proteins that promote cell survival.

Among patients with non-small cell lung cancer (NSCLC) fueled by ALK gene alterations who were being treated with crizotinib (Xalkori), a decrease in the number of circulating tumor cells (CTCs) harboring increased copies of the ALK gene over the first two months of treatment was associated with increased progression - free survival.

When we experimentally increased the expression of the microRNAs in model nerve cells designed to replicate the conditions of HD, the cells lived longer, indicating that these miRNAs may promote cell survival,» explained lead author Richard Myers, PhD, professor of neurology at BUSM.

Morris says vaccination with modified tumor cells producing IL - 15 and IL - 15Rα slowed tumor growth and led to increased survival for animal models.

Their results demonstrate that specific rhoptry and dense granule effector proteins that T. gondii secretes before and after host cell invasion, respectively, control the development of an effective host antitumor response, and increase the survival of mice with ovarian tumors.

Cancer cells undergo metabolic alterations to meet the increased energy demands that support their excess growth and survival.

«A way to stabilize haploidy in animal cells: Mammalian haploid cells present problems during mitosis that limit their viability; the removal of the p53 tumor suppressor gene increases the survival rate of these cells thereby stabilising their haploid state.»

The increase in autophagy protected the cells from dying and increased survival in the mouse models of BPD.

Moreover, injection of 5E5 CAR T cells into mice with leukemia or pancreatic cancer reduced tumor growth and increased survival.

4 «Mobile Zinc Increases Rapidly in the Retina After Optic Nerve Injury and Regulates Ganglion Cell Survival and Optic Nerve Regeneration,» January 2017, https://www.ncbi.nlm.nih.gov/pubmed/28049831

The prognosis for metastatic cancer (also called stage IV cancer) is generally poor, so a technique that could detect these circulating tumor cells before they have a chance to form new colonies of tumors at distant sites could greatly increase a patient's survival odds.

«Reprogramming bone cells obtained from patients might increase their survival rate from 30 % to 60 %, which will ultimately lead to better bone regeneration.

Injecting the TRAIL - expressing stem cells into the carotid artery, a likely strategy for clinical application, led to significantly slower tumor growth and increased survival, compared with animals receiving unaltered stem cells or control injections.

«Work continues to identify the other factors, including small molecules, necessary to not only promote the maturation and survival of the newly generated hair cells, but also increase their number,» Zuo said.

Recently, we showed that bortezomib treatment in mice bearing breast and kidney tumors provided host survival benefit by amplifying tumor cell caspase8 activation, CD8T cell effector molecules via increased NotchNFkB crosstalk and Fas ligandmediated lysis of tumor cells.

Now, in a new study in the journal Cancer Cell, Shaw and a team of scientists at the Salk Institute for Biological Studies found that phenformin, a derivative of the widely - used diabetes drug metformin, decreased the size of lung tumors in mice and increased the animals» survival.

• Keeping abnormal proteins from building up and potentially shutting down major organs (heart, liver and nervous system, to name a few) • Protecting the brain's functions of learning and memory against neurotransmitter toxicity • Activating or increasing the activity of proteins that promote the initial growth, maintenance and survival of brain neurons • Enhancing the movement of proteins, lipids and other cell parts through the cytoplasm of cell bodies.

One promising solution to increase long - term overall survival has been in the area of allogeneic hematopoietic stem cell transplantation (HCST).

Injections of iPSC - EPCs did not however have significant effect on tumor growth or on overall survival, but transducing cells with a baculovirus expressing CD40L, a member of the TNF gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis, increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L carried by the EPCs (See figure).

The role of these molecules in driving disease pathology might vary, with described activities of HVEM signaling promoting T cell expansion or survival, analogous to certain activities of OX40 and 4 - 1BB, and other activities of HVEM or LTβR increasing the function of diverse cells such as stromal cells, dendritic cells, macrophages, eosinophils, epithelial cells and keratinocytes.

Dr. Pfaff has developed a novel embryonic - stem cell - based model of SMA that phenocopies the pathology of human SMA, and can be used to study the basis of the disease and screen for compounds that might increase survival of motor neurons.

Dr. Sadelain's work has focused on developing novel strategies to extend survival of CAR T cells in the body and enable T cells with increased potency to overcome the resistance imposed by tumor and other cells in the tumor microenvironment.

In contrast, although SCI rats that were treated with hGPCs and hGDAsCNTF showed positive trends in neuron protection for laminae 8 and 9, this did not translate to improvements in grid - walk performance and these cells failed to promote statistically significant increases in neuronal survival even in laminae into which they had migrated.

Interestingly, BDNF improves pregnancy rates by increasing trophoblast cell growth and survival via its receptor NTRK2 expressed by the trophectoderm of blastocysts [37].

The CRISPR - Cas9 genome editing system could help fight cancer, and now, researchers have used the tool to target what they call cancer's command center, in a treatment that's been shown in mice to shrink aggressive tumors and increase survival rates, without harming healthy cells.

Clinical studies identify FLT3 ITD mutations associated with higher numbers of leukemic cells, increased incidence of relapse and decreased overall survival.

These data suggest that ABL kinases promote breast cancer metastasis to bone in part by increasing tumor cell survival within the bone microenvironment.

In mice, which are mammals like humans, MSI - 1436 improved heart function, increased survival, reduced scarring and stimulated the proliferation of heart muscle cells.

Many clinical studies have found that FLT3 ITD mutations are associated with higher concentrations of leukemic cells in both blood and bone marrow, increased incidence of relapse and decreased overall survival.

Tumor hypoxia is often linked to decreased survival in patients with breast cancer and has been shown to induce specific molecular changes in cells including changes that confer a more malignant phenotype such as increased proliferation (3), survival (4), invasion (5), and metastasis (6).

The anti-inflammatory effect of GABA may be vital in the pancreatic islets since as long as GABA is present, toxic white blood cells can be inhibited, thus increasing the survival of the insulin - secreting beta cells.

Exercise also increases the generation of neurochemicals, such as IGF - 1 and BDNF, which promote growth, survival, differentiation and repair of brain cells.

[3] Low muscle mass is associated with increased risk of dose - limiting chemotherapy toxicities, such as low white blood cell count and reduced overall survival, and therefore it is extremely important to maintain muscle mass in advanced cancers.

Among it's valuable components are gamma - linolenic acid (GLA), linoleic and arachidonic acids, vitamin B12 (needed, especially for vegetarians, for healthy red blood cells), iron, a high level of protein (60 to 70 percent), essential amino acids, the nucleic acids RNA and DNA, chlorophyll, and phycocyanin, a blue pigment that is found only in blue - green algae and that has increased the survival rate of mice with liver cancer in laboratory experiments.

L - Pyroglutamate, or L - pyroglutamic acid, an uncommon amino acid contained in GenFX, has been shown in third party tests to increase cognition by increasing survival of neuronal cells (* Oono et al. 2009).

Lithium might also protect the brain from numerous damaging compounds by increasing bcl - 2, a protein that may improve the survival of brain cells even possibly from damage cause by a stroke.

From plants to metazoans, an increase in intracellular levels of NAD + directs cells to make adjustments to ensure survival, including increasing energy production and utilization, boosting cellular repair, and coordinating circadian rhythms.

It has been proven that when you place the Reticare protective sheet over electronic devices screens the survival rates of retina cells increase up to 83 %.