This has obvious psychosocial implications, but from a medical standpoint, the reason we're so concerned is that those who start developing at a younger age are at an increased risk of breast cancer later in life, due to
the increased estrogen exposure.
Increased conversion to estrogen may be due to age, weight gain, poor diet, lack of exercise, high stress, and hypothyroidism, and increased SHBG may occur from
increased estrogen exposure (e.g., weight gain, birth control, plastics / environmental endocrine disrupting chemicals), cigarette smoking, hyperthyroid (increased production) stress, and poor liver health (e.g. elevated liver enzymes).
Indeed, there is a strong assocation between
increased estrogen exposure and a reduced POAG risk.
Not exact matches
Conversely, studies have shown that a decreased
exposure (i.e. early loss of
estrogens), confers an
increased risk of POAG.
There was a HIF - 1α — dependent CSC
increase in ER - α — positive cancers following hypoxic
exposure, which was blocked by inhibition of
estrogen and Notch signaling.
Even low
exposures of BPA, for example, a common chemical in plastics, can
increase our risk of breast cancer because it has
estrogen - mimicking biological activity.
[8]
Increased exposure to environmental
estrogens and other environmental pollutants during fetal development, as well as during the reproductive years, is suggested as a major reason for the tremendous rise in disorders of development and function of the male sexual system.
An
increase in lifetime
exposure to
estrogen: There are many factors that
increase a woman's lifetime
exposure to
estrogen.
Fewer pregnancies — many women today are restricting how many children they are having or are not having children at all, which
increases their total
exposure to
estrogen
And, because many forms of hormonal birth control contain types of
estrogen, and
exposure to
estrogen is a risk factor for breast cancer, many people wonder if hormonal birth control might
increase users» chances of developing breast cancer later in life.