Sentences with phrase «increased expression levels»

Two thirds of the animals showed equivalent expression values but the remaining five had increased expression levels up to ten fold higher than the mean expression across all animals (Figure S2C).

Additionally, we... found increased expression levels of genes that are considered to be associated with AD (BACE2, RCAN1, ETS2, TMED10), as compared to healthy controls.

found increased expression levels of genes that are considered to be associated with AD (BACE2, RCAN1, ETS2, TMED10), as compared to healthy controls.

CR increases the expression levels of SIRT1 7, 8, SIRT3 9 and SIRT5 10, while high fat diet has been demonstrate to reduce SIRT1 expression 11.

J147 treatment of aged huAPP / PS1 mice increases the expression levels of several proteins involved in neurotrophin signaling.

One of the lines derived had higher levels of ACAN at 2 weeks and during 3D culture formed high levels of extracellular matrix (Alcian blue van Gieson staining), high levels of collagen II deposition and increasing expression levels of ACAN, SOX9, and COL2A1 types A and B, overall suggesting a high cartilage differentiation capacity.

Not exact matches

Unfortunately, we were far from unique in holding this opinion, and expressions of interest kept pouring in such that the underwriters were able to both increase the size of the bond offering and reduce the interest rate to 4.25 %, at which level we had no desire to participate.

In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.

Liu notes that since all glaucoma patients were under treatment, their medication's impact on those levels could not be ruled out, but he suspects that increased expression is a hallmark of the disease state.

Elevated miR - 182 expression already is associated with premature aging of the eye and, when MCG scientists mimic premature aging by applying hydrogen peroxide, miR - 182 levels increase.

This research suggests that therapy with an agent that increases levels of Dicer or specific miRNA expression could be beneficial to people with metabolic syndrome.

Increasing the expression of one of the proteins, SIX3, in the insulin - producing cells isolated from younger donors enhanced their ability to respond efficiently to rising glucose levels.

The researchers» findings indicated that decreased pupil dilation to emotional facial expressions predicted a significant increase in post-flood depressive symptoms, but only among women who experienced higher levels of flood - related stress.

«The genes which these miRNAs regulate also had increased levels, indicating that these gene expression, indicating that these gene products were likely targeted for storage and for possible future use within the brain cell, rather than for destruction.

Borrelli said they observed a remarkable decrease in expression levels of some 2,000 genes in this area, coupled with a widespread increase in modifications of basic DNA proteins called histones — particularly those associated with reduced gene activity.

Three decades of research have shown that loneliness can affect levels of stress hormones, immune function, and even gene expression, while human interaction increases levels of oxytocin, a bonding hormone that reduces blood pressure and cortisol levels.

To validate their findings, the scientists injected the novel nanoparticles into pancreatic tumor - bearing mice and observed that by balancing these two targets — bringing them to a normal level by increasing their expression or blocking the gene responsible for their expression — they significantly prolonged the survival of the mice.

The increase in JAK1 was due to low levels of the protein that regulates its expression, ubiquitin ligase RNF125.

They found higher levels of JAK1 in resistant tumors, which caused increased expression of epidermal growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes cell proliferation.

They confirmed low levels of miR - 184 expression in human glioma tissue samples and cultured cell lines as well as an increase in the expression of SND1 compared to normal brain tissue.

Low levels of oxygen and nitric oxide both increase expression of P - selectin.

«Interestingly, because deltaFosB is a transcription factor, meaning that its job is to regulate the expression of other proteins, these findings led us to predict that the increased deltaFosB levels might be responsible for suppressing the production of proteins that are necessary for learning and memory,» Chin said.

When they either prevented deltaFosB activity or experimentally increased calbindin expression in the mice, calbindin levels were restored and the mice improved their memory.

And when researchers experimentally increased deltaFosB levels in normal mice, calbindin expression was suppressed and the animals» memory deteriorated, demonstrating that deltaFosB and calbindin are key regulators of memory.

This observation is further supported by the fact that studying alterations in the expression of genes also made it possible to identify persons whose levels of interleukin 6, an inflammation marker, were reduced as their serum vitamin D levels increased.

Surprisingly, Peyer's patch B cells have an increased level of GARP expression, likely needed to regulate the activation of these B cells.

They also stressed that IL - 6's role in inflammation «extends well beyond the immune system and the kidney, with high levels of expression in atherosclerotic plaques and elevated serum levels being associated with increased coronary artery disease and morbidity from hypertension, left ventricular hypertrophy, and development of insulin resistance.»

They also found no increase in the levels of angiogenesis - inducing factors or in the expression of angiogenesis - related genes in metastatic lymph nodes.

Through analyzing several datasets of prostate cancer cases and patient outcomes, the researchers found that a high level of expression of two genes, TOP2A and EZH2, was associated with early recurrence of prostate cancer and metastatic spread, leading to an increased risk of death.

That means the human brain is wired to react to facial expressions even without vocal cues — a dominant smile suggests a potential threat, so stress level increases.

Unlike most biomarkers for cancer, DDX3 mRNA expression only increased slightly in the exposed breast cells, but the corresponding proteins levels were significantly higher.

The level of D2 expression did not increase in the female autism mice.

In celiacs, this non-coding RNA is hardly produced at all so the levels of these inflammatory genes are not properly regulated and their expression is increased.

When the p27 gene was deleted in mice, GATA3 levels increased along with expression of POU4F3.

Since GATA3 and ATOH1 work together to increase expression of POU4F3, reducing GATA3 levels also reduced expression of POU4F3.

Starvation accelerates this response, at least partly through induction of ALAS expression and a consequent increase in porphyrin levels.

In addition, expression analysis revealed that, like kakusei, Acks transcript expression levels transiently increase after seizure induced by awakening from anesthesia (Figure 1B and C), and the induced Acks expression can be broadly visualized in several brain regions (Figure 2).

In addition, temporal [17] and spatial [16,17] correlations between increased levels of HIF - 1α, the regulatory subunit of HIF - 1, and increased VEGF expression have been shown, indicating that HIF - 1 may control the expression of VEGF in the retina under hypoxic conditions.

Psychological stress and glucorticoids have been shown to increase FOXO3 in animal studies, 36, 37, 38 whereas low levels of FOXO3 in mice actually prevent the behavioral stress response in mice, serving an antidepressant effect.39 We believe our study is the first documentation that a stress reduction intervention can reduce FOXO3 expression.

Cyclin D1 - levels varying throughout cell cycle, hence its expression in G1 phase increases in the cell that respond to enter a new cycle after receiving growth factor stimulation [8].

The increase in the Aβ42 / Aβ40 ratio (driven by a decrease in plasma Aβ40 levels) could also be related to the observed decrease in expression of CLU as part of the relaxation effect (P = 0.00045).

In par with these studies, the propensity to increase the levels of inflammatory cytokines (IL - 6 and IL - 1β) expression in islets of WNIN / Gr - Ob rats were exacerbated with L - arginine administration in mutants.

Under those optogenetic controls, gene expression levels reliably increased in vitro by a factor of 10 to 20.

CDDO - Me was able to derepress both the mutant and wild - type Bach1 proteins, resulting in increased levels of ARE - dependent gene expression.

Although there was no effect in the null mutant, we found ilp2 mRNA expression increased and AKT expression level was down regulated in larvae where either TOR signaling activity or the expression of GBP1 and GBP2 was specifically reduced in the fat body.

For example, 2xHAR.142 and 2xHAR.114, like many other HARs, function as enhancers, which increase or decrease the level of a gene's expression.

Rather, HAR2 functions as an enhancer, a DNA sequence that works to increase or decrease the level of a gene's expression.8 An enhancer can be located thousands of base pairs away from the gene it regulates.

When they also looked for human genes with significantly higher or lower expression levels, they found 14 genes with increased expression and five with decreased expression.

In the AD mice, the expression of ERK1 / 2 was significantly increased (p < 0.05), while the level of BDNF was decreased (p < 0.05).

Silencing of Nrf2 significantly decreased baseline levels of HMOX1, whereas silencing of Bach1 resulted in a 50-fold increase in expression of HMOX1 mRNA (Figure 4B).