In Study 2, rats fed fermentable RS had increased cecal weights and plasma PYY and GLP - 1, and
increased gene transcription of PYY and proglucagon.
Not exact matches
The epigenetic impairments reflect changes that
increase accessibility of chromatin, a process that enhances
gene transcription, suggesting the impairments play an important role in addiction behavior.
They found that during the transition period, cells expressed
increasing amounts of a
gene encoding the
transcription factor Zscan4.
Mal - gluc modulates histone acetylation of the Rac1
gene and allows
transcription activators to access the DNA for
increased transcription in the brain, which influences the expression of
genes responsible for synaptic plasticity.
Similarly, Bernaudin et al. [43] found
increased expression of 18
genes in the neonatal rat brain following hypoxia (8 % O2 for 3 h) including several known hypoxia inducible
genes such as MAP kinase phosphatase - 1 (MKP - 1), several HIF - 1 target
genes including VEGF and GLUT - 1,
genes implicated in apoptosis, signal transduction molecules, and
transcription factors.
«We suggest that such abundant and complex
transcription may
increase gene -
gene interactions and constrains coding - sequence evolution.»
The signal transducer and activator of
transcription 6
gene (STAT6)
increases the propensity of patients with atopic dermatitis toward disseminated viral skin infections.
Pozhitkov et al. 29 described an
increased expression of epigenetic regulatory
genes, hypothesizing that the activation of these
genes reveals the nucleosomes and allows for the later
transcription of developmental
genes that have no early expression.
Activation of the UPR induces the production of a family of basic leucine zipper - containing
transcription factors that activate
transcription of
genes encoding functions to reduce the protein - folding load and
increase the protein folding capacity of the ER.
«This study identifies how the modification of the DNA structure affects the binding of
transcription factors, and this
increases our understanding of how
genes are regulated in cells and further aids us in deciphering the grammar written into DNA,» study co-author Jussi Taipale from Karolinska Institutet in Sweden said in a statement.
During periods of oxidative stress, as levels of reactive electrophilic metabolites
increase, the ability of Keap1 to target Nrf2 for ubiquitin - dependent degradation is disrupted, thereby
increasing Nrf2 protein levels and its transport into the nucleus, resulting in
transcription of antioxidant response
genes [5], [6], [8], [10], [11].
Increased expression of
transcription factor ATF2 — which is required for the amino acid depletion responses of
genes such as ATF3, CHOP, SARS and 4EBP - 1 — is mediated by a signal transduction pathway that appears to involve an amino acid sensing GPR [37].
Additional
gene duplication and divergence in eumetazoans further
increased transcription factor
gene family number, which in general are 2 to 34 times larger in eumetazoans than in Amphimedon.
Interestingly, it has been reported that reduced levels of two modifiers of epigenetic
gene silencing, Dnmt3a and Kap1, cause an
increased phenotypic noise, suggesting that faithful epigenetic control of
transcription is central to suppressing deleterious levels of phenotypic variation [43].
Under hypoxic conditions activates the
transcription of over 40
genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other
genes whose protein products
increase oxygen delivery or facilitate metabolic adaptation to hypoxia.
Provocatively,
genes controlled by Oct4 heterodimers (Oct4 itself, fgf4 [6], [13]-RRB- showed either no
increase or a slight decrease in transcript levels, whereas those controlled by PORE homodimers (fgf12, osteopontin, mIR - 124a) generally displayed enhanced
transcription (Figure 3E and Figure S1, albeit with distinct kinetics).
Our results support the well - known fact in different mammalian species that IVC
increases the
transcription at blastocyst stage of a large number of
genes, suggesting a decrease in repressive epigenetic marks [7, 44].
The
increased CDK9 levels in the SEC was most likely due to the enhanced
transcription of the three SEC
genes as revealed by qRT - PCR (Figure 6B), which in turn resulted in elevated levels of these proteins in the nuclear extracts (Figure 6A).
In addition, the DHA and EPA found in fish oil have a powerful ability to enhance the metabolism and
increase fat burning by positively altering the
gene functioning through various mechanisms which include changing the makeup of cell membranes, altering the
transcription of
genes and influencing the levels of calcium within the cells.
In Study 3, RS - fed rats had
increased short - chain fatty acids in cecal contents, plasma PYY (GLP - 1 not measured), and
gene transcription for PYY and proglucagon.
Decreased mTORC1 activation and subsequent decreases in muscle protein synthesis, coupled with
increased FOXO nuclear localization,
increased transcription of atrophy - related
genes, with up - regulated caspase 3 activation and muscle protein ubiquitylation provide a possible mechanism contributing to skeletal muscle loss in response to periods of negative energy balance.
Essentially they are anti-inflammatory agents and work by
increasing the expression of various inflammatory
genes that regulate proinflammatory
transcription factors (14).
If
gene transcription were
increased, the density of 1b receptors would be amplified, which could lead to an
increased inhibition of serotonin release.