Sentences with phrase «increased growth of cells»

The discharge appears because your vagina's walls are beginning to thicken and there is an increase growth of cells.

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These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

We anticipate some sort of growth toward increased complexity: increasingly larger organic macromolecules, then the convergence of many macromolecules to constitute a simple living system, either as a cell with its protective wall and vital nucleus or as some functional analogue, then the convergence of many cells to form larger organisms.

It seems to decrease cell growth, increase self - destruction of abnormal cells and shift estrogen metabolism to less cancer - promoting forms.»

«You're giving people a hormone that canpotentially increase the growth of abnormal cells.»

«In animal studies, exercise has been shown to specifically affect the hippocampus, significantly increasing the growth of new neurons and cell survival, enhancing memory and learning, and increasing molecules that are involved in the plasticity of the brain,» Chaddock said.

They found that exercise may help cognition by increasing blood and oxygen to the brain, increasing levels of norepinephrine, and endorphins to decrease stress and improve mood, and increasing growth factors that help create new nerve cells and support synaptic plasticity.

«When a new substance forms during a chemical reaction, many students think that the atoms and molecules have actually changed into something new, whereas they simply rearranged, that the mass increase of plants is due to minerals in the soil, or that cell division alone accounts for animal growth,» said Cari Herrmann Abell, a senior research associate at Project 2061.

After EZH2 enzymes rise, their levels taper off, and then, the scientists found two to three-fold increases in a protein called DNMT1, which maintains DNA methylation in the «start» location of a variety of tumor suppressor genes that normally suppress cell growth.

Meanwhile, recent human studies indicate that aging is associated with an increase in somatic mutations in the hematopoietic system, which gives rise to blood cells; these mutations provide a competitive growth advantage to the mutant hematopoietic cells, allowing for their clonal expansion — a process that has been shown to be associated with a greater incidence of atherosclerosis, though specifically how remains unclear.

The researchers took this discovery and, in an animal model, identified a drug that is able to re-activate those immune cells and reduce brain tumor growth, thereby increasing the lifespan of mice two to three times.

In support of this finding, experiments also revealed that an increase in cellular TIP60 levels could inhibit cancer cell growth.

In addition, scientists found an increase in the markers for the growth of cancerous cells and liver inflammation in both groups exposed to the carcinogen.

Increasing levels of PUMA only affected stem - like cells that were starting to spread and not the growth of primary tumors.

Frigo and his team demonstrated in this study that androgens take control of the AMPK signaling cascade, a master regulator of metabolism, to increase prostate cancer cell growth.

Eventually, she says, it might be possible to use our increased understanding of RFX transcription factor to treat hearing loss, by either protecting hair cells from death or fostering their growth.

Increased SQLE expression promotes the biosynthesis of cholesteryl ester, which induces NAFLD - HCC cell growth.

The study found that the insulin - like growth factor 1 (IGF - 1) hormone, known for its pivotal role in tissue growth, is also capable of increasing the lithium sensitivity of blood cells in bipolar disorder patients in whom lithium was originally ineffective.

Auxin promotes cell division and growth, increasing weight and firmness of the fruit.

They discovered that IGF2BP3 binds to and stabilizes hundreds of leukemia - promoting RNA messages and consequently increases how much protein is made, resulting in an environment that is conducive to leukemia cell growth.

«We found that E. lignolyticus SCF1 is capable of degrading 56 - percent of the lignin under anaerobic conditions within 48 hours, with increased cell abundance in lignin - amended compared to unamended growth,» Simmons says.

They found higher levels of JAK1 in resistant tumors, which caused increased expression of epidermal growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes cell proliferation.

The team found that individuals with long - standing type 1 diabetes and diabetic enteropathy have altered colonic stem cells (CoSCs) and increased blood levels of a regulatory protein called insulin - like growth factor binding protein 3 (IGFBP3), which is produced in the liver.

Plant growth occurs by increasing the number of cells by cell division followed by enlargement of the cells.

Therapies could seek to increase or decrease the amount of HIF to deliver more oxygen to anemic cells or suppress cancerous growth.

Through a variety of preclinical experiments, the team demonstrated that increasing the expression of miR - 184 slows the growth and invasive characteristics of glioma cells through direct regulation of SND1.

They promote the growth of cancerous cells by releasing growth factors and increasing the response of certain proteins that regulate tumor cell development (oncoproteins).

Using this marker, the green fluorescence of the nucleus increases progressively in cells in the growth phase and turns off after the division.

Moreover, injection of 5E5 CAR T cells into mice with leukemia or pancreatic cancer reduced tumor growth and increased survival.

The data are the same across papers, and so are the conclusions: The molecule is a powerful inhibitor of cancer cell growth, and it increases the sensitivity of cancer cells to radiotherapy.

The group observed that, at the cellular level, one of the side effects of the diet was an expansion of hair follicle stem cells, leading to increasing hair follicle growth and retention rates.

However, an overactive stimulation of mTOR in response to nutrients and growth factors — metabolic processes that are crucial in tumor biology — leads to an increase in cell growth and proliferation.

Other studies show that visceral obesity raises a person's risk of developing colon cancer, perhaps because it increases circulating levels of hormones that affect cell growth.

They found that the drug increased the level of lactate in cells and, more importantly, reduced tumour growth.

They have a burst of growth that increases the pool of cells waiting for the next mutation to push them even further.

A more alkaline growth medium, for example, made the autoinducer less stable, slowing activation of the cell - suicide gene and increasing the population.

Either drink delivers a sugar shot that increases insulin and insulinlike growth factor, «both of [which] promote inflammation and both lead to cancer cell division,» says Abrams, who is also professor of clinical medicine at U.C.S.F., and chief of hematotology / oncology at San Francisco General Hospital.

When a chemical that inhibits entosis was applied to a line of breast cancer cells, colony formation — an indicator of tumor growth in vitro — increased 10-fold.

In contrast, the growth of clones derived from progenitor cells becomes checked by increasing levels of apoptosis, leading to the formation of benign lesions.

Like volunteers handing out cups of energy drinks to marathon runners, specially engineered «helper cells» transplanted along with stem cells can dole out growth factors to increase the stem cells» endurance, at least briefly, Johns Hopkins researchers report.

Additionally, overexpression of POSTN in human mammary epithelial and breast cancer cells resulted in enhanced tumor growth and metastasis (Wang et al., 2013), which is similar to a colon cancer cell model where overexpression of POSTN resulted in an increase in the number and size of liver metastases (Bao et al., 2004).

Biologically, hypermethylation often silences genes that keep runaway cell growth in check, and its appearance in the DNA code of breast cancer - related genes shed into the blood may indicate that a patient's cancer growth is increasing and the disease has worsened.

Mutations in the gene increase rat susceptibility to mammary cancer and FRY reduced the growth of highly aggressive human breast cancer cells.

The frequency of CD39highCD8 + T cells increased with tumor growth but was absent in lymphoid organs.

Leukemic cells can feed themselves through increased secretion of hepatocyte growth factor (HGF), which then activates its receptor, MET, to promote growth.

In this study these cells were treated with a combination of gamma secretase inhibitor and BRAF inhibitor, a reduction in cell growth and an increase in senescence was observed in these resistant cells.

Autocrine fibroblast growth factor 2 increases the multipotentiality of human adipose - derived mesenchymal stem cells.

Finally, we demonstrate that treatment of T - 47D cells with epidermal growth factor (EGF), which promotes cell ruffling, stimulates increased accumulation of activated matriptase at the sites of membrane ruffling, suggesting a possible functional role at these sites.

Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells.

The TRPC channel blocker SKF 96365 Inhibits Glioblastoma Cell Growth by Enhancing Reverse Mode of the Na + / Ca2 + Exchanger and Increasing Intracellular Ca2 +.