Sentences with phrase «increased kinase activity»

It has been shown in imatinib - resistant CML that drug resistance conferred by mutations does not necessarily correlate with proliferative advantage and increased kinase activity.34 Other, non-activating mutations or drug - resistance mechanisms, might be acquired by tumor cells.

Not exact matches

P significantly increased hypothalamic cAMP levels and cAMP - dependent protein kinase activity.

They found that an enzyme called DNA - dependent protein kinase, or DNA - PK, increases in activity with age.

In addition, caffeine may increase the activity of several signaling enzymes, including the calcium - dependent protein kinase and protein kinase B (also called Akt), which have roles in muscle glucose uptake during and after exercise.

Pterostilbene also increases activity of the AMPK (adenosine monophosphate - activated protein kinase) pathway, which regulates production of energy, reduces chronic inflammation, lowers levels of blood sugar and fats in the blood, and reduces stores of body fat.

In addition to causing the functional inactivation of these phosphatases, low concentrations of H2O2 or an oxidative shift in the GSH: GSSH redox status strongly increases the activity of the basic insulin receptor tyrosine kinase in the absence of insulin.

The resulting increase in free amino acid concentrations activates the serine / threonine kinases, Akt1 and Akt2, which mobilize the signaling protein mTOR (the mammalian target of rapamycin), which then suppresses autophagic activity.

RESULTS: Anthocyanin Cy -3-g increased cellular AMPK activity in a calmodulin kinase kinase dependent manner.

In addition, altered enzymatic activities, such as an increased phosphatase activity and / or seryl phosphorylation of the insulin receptor substrate by glycogen synthase kinase - 3 (GSK - 3), have also been shown to be involved in some cases of type 2 diabetes (19,20).