Not exact matches
[6] In the MSLT - 1 trial, patients with isolated nodal recurrence had more total lymph nodes involved by melanoma than patients randomized to SLN biopsy who had a positive biopsy (all of whom were to have CLND; an average of 3.2 lymph nodes involved with metastatic melanoma vs only 1.4 positive nodes, respectively; P <.0001), [2] and were more likely to meet established criteria for adjuvant radiation, [7] which further
increases the risk of postoperative
lymphedema.
[6] Therefore, the benefit some patients may derive by avoidance of lymphadenectomy is counterbalanced by higher morbidity, including
increased risk of moderate to severe
lymphedema and longer hospital stays in the event that a delayed CLND is required following observation.
For maximum effectiveness of Butcher's Broom liquid tinctures and liquid extracts, vitamin C should be taken every day, as well, since vitamin C can
increase the potency against hemorrhoids and
lymphedema.