Sentences with phrase «increased necrosis»

Across multiple triple - negative breast cancer subtypes, inhibiting the androgen receptor greatly increased apoptosis (programmed cell death), inhibited growth and increased necrosis by 60 percent in animal models.

Not exact matches

Researchers in Sweden sought to determine if use of tumor necrosis factor inhibitor drugs to treat RA would result in a reduced risk of acute coronary syndrome (commonly called ACS), defined as a diagnosis of a heart attack or unstable angina (the worsening or increasing cardiac symptoms)

The scientists also found consistent evidence of increased pro-inflammatory markers, such as C - reactive protein and tumor necrosis factor alpha, associated with PTSD.

Of note, several proteins involved in the tumor necrosis factor, or TNF, pathway increased in activity during the induction and execution phases.

Enhanced monocyte binding to human cytomegalovirus - infected syncytiotrophoblast results in increased apoptosis via the release of tumour necrosis factor alpha.

Severity of pancreatitis in obesity may be attributed to increased oxidative stress, free fatty acid production, fat necrosis and increased inflammation [8].

In addition, inflammatory cytokines and transcription factors have also been shown to be upregulated in taurocholate - induced AP in obese zucker rats leading to increased oxidative stress, fat necrosis and isoprostanes levels, as compared to lean controls [7].

This has been evidenced by 1) increased acinar cell necrosis, 2) increased serum amylase and lipase, 3) higher hepatic damage, 4) altered liver function test, 5) increased kidney damage, 6) increase in serum urea and creatinine, 7) altered distribution of pancreatic cells, 8) increased vacoulation and irregular islets, and 9) mild fibrosis in exocrine regions.

Increased free radical induced oxidative stress plays a pivotal role in pathogenesis of many diseases including obesity, T2D and AP [7, 39 - 43] leading to macromolecular damage (DNA, protein and lipids), inflammation, ER stress and necrosis of acinar cells [44].

Regular meditators showed a trend toward increased telomerase activity compared with randomized women, who showed increased plasma Aβ42 / Aβ40 ratios and tumor necrosis factor alpha (TNF - α) levels.

Stem cells affect the infarcted myocardium via neovascularization, reduction of apoptosis and paracrine effect, they are able to increase myocardial perfusion, inhibit synthesis of pro-inflammatory cytokines (IL6 and TNFα) and promote expression of anti-inflammatory cytokines (IL10) minimizing the necrosis damage caused by local inflammatory reaction.

In the tail models, although a substantial frequency of tail necrosis (30.0 %) was noted and the increase in circumference was maintained for only limited times postoperatively depending on the particular tail model, the overall success rate was 65.0 %.

Although vaccination induces an inflammatory response during pregnancy, the magnitude and the duration of response is much lower and shorter, respectively, for influenza vaccination than viral infection.27 Like infection, influenza vaccination during pregnancy has been reported to induce a transient increase in the levels of a number of proinflammatory cytokines, including interleukin 6, tumor necrosis factor α, and C - reactive protein.27 - 30 Studies on mice found an association between high interleukin - 6 levels during pregnancy and abnormal behavior and brain structure.19 However, in epidemiological studies, associations between maternal cytokine levels and ASD have been mixed.

Manuscripts that increase our understanding of the processes through which stem cells and progenitors differentiate into committed progeny, the commitment cell death programs such as apoptosis and necrosis, aging, and the transition between proliferation and cell cycle arrest are welcome.

Another reason is that stress prevents the elimination of lipids from the blood, and a third possible reason is that stress increases the production of a large number of inflammatory processes such as interleukin 6, tumor necrosis factor and C - reactive protein, which also increase production of lipids.

The researchers explained that prescription bone - building drugs are costly, and most have side effects, which ironically include an increase in hip fractures and jaw necrosis.

The research, which was funded by the Food and Drug Administration and other federal health agencies, contradicts numerous earlier studies that did find an increased risk of infection associated with the drugs, known as tumor necrosis factor (TNF) inhibitors.

One theory proposes that once the storage capacity of subcutaneous adipose tissue (SAT) depots is exceeded under conditions of energy excess, either as a result of impaired expandability and / or excessive hypertrophic growth, fat deposition within visceral depots and non-adipose tissues including the liver, skeletal muscle and pancreas can ensue.93 This can subsequently lead to the development of systemic IR and a series of associated cardiometabolic disorders including dyslipidaemia, dysglycaemia, hyperinsulinaemia and hypertension.3 Expression of pro-inflammatory mediators including interleukins 1 (IL - 1), 6 (IL - 6), tumour necrosis factor alpha (TNF - α) and resistin, are also increased which can further potentiate IR and promote atherosclerosis.

Epidemiologic data, acknowledging all of its shortcomings, has revealed that chronic inflammation correlates with tumor progression in patients already with cancer.11 C - reactive protein (CRP), tumor necrosis factor (TNF), and IL - 6, all cytokines known to be increased from stress, are also increased in cancer patients.12, 13

Enhanced cortisol increase upon awakening is associated with greater pain ratings but not salivary cortisol or soluble tumor necrosis factor - α receptor II responses to acute pain.

Duntas (2015) articulates, «In susceptible individuals, iodine excess increases intra-thyroid infiltrating Th17 cells and inhibits T regulatory (Treg) cells development, while it triggers an abnormal expression of tumor necrosis factor - related apoptosis - inducing ligand (TRAIL) in thyrocytes, thus inducing apoptosis and parenchymal destruction» (31, p. 721).

The scientists found that feeding the rats fluoride substantially increased levels of two pro-inflammatory cytokines called tumour necrosis factor alpha (TNF - a) and resistin.

In one study on more than 3000 post-menopausal women, [23] increased magnesium intake was responsible for reducing three separate biomarkers for inflammation: CRP (C - reactive protein), TNF (tumor necrosis factor alpha), and IL6 (interleukin - 6).

The numerous flavonoids found in astragalus appear to enhance cell - mediated immunity by increasing the number of T - helper cell type 2 cytokines, increasing levels of tumor necrosis factor and interleukin - 6, which stimulates the activity of macrophages, responsible for killing potentially harmful cells.

Researchers followed a subset of 1,139 subjects and found that those with the greatest increases in urinary polyphenols had significantly lower levels of five different biomarkers of inflammation, such as adhesion molecules, interleukin, tumor necrosis factor alpha, and monocyte chemotactic protein.

Endotoxin impairs mitochondria, increases estrogen levels, causes Kupffer cells in the liver to produce more tumor necrosis factor, etc..

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

Rats were fed genetically modified corn chow on a daily basis for two years and the results included an exponential increase in mammary tumors, kidney failture and liver necrosis in the rats who ate GMO food compared to their control counterparts.

Another is local inflammation which is an increased production of what are called cytokines, like tumour necrosis factor for example.

As the severity of gastric necrosis increases, the prognosis decreases, reaching as high as 90 % mortality for severe necrosis, despite the level of surgical expertise.

The result can be necrosis (cell death caused by degradation), hyperplasia (abnormal increase in normal cells) and hemorrhage (bleeding).

Muscle biopsies reveal multifocal necrosis, hypertrophy, atrophy, increased fibrosis and a variable increase in the number of fibers with internal nuclei and occasional whorled fibers.

If the CARS response is excessive the lack of inflammation can increase susceptibility to secondary infections and pancreatic necrosis, which is much more common in people than dogs and cats.

High - hostile couples also produced relatively larger increases in plasma IL - 6 and tumor necrosis factor α values the morning after a conflict than after a social support interaction compared with low - hostile couples.