Sentences with phrase «increased oxidative damage»

Aging of the retina is linked to increased oxidative damage levels, and oxidative stress is believed to play a crucial part in the development of age - related macular degeneration.

A major cause of aging is increased oxidative damage caused by ROS.

According to lead author Dr Ismael Galván of the Spanish National Research Council (CSIC): «Previous studies of wildlife at Chernobyl showed that chronic radiation exposure depleted antioxidants and increased oxidative damage.

«As we age, we suffer increasing oxidative damage, and so the levels of oxidative markers increase in our body.»

The inclusion depletion of Glutathione, mitochondria increase lipid peroxidation and increase oxidative damage of proteins and DNA in the brain.

Not exact matches

One study published in the American Academy of Optometry's Optometry & Vision Science journal found that using goji berry daily as a dietary supplementation for 90 days increases plasma zeaxanthin and antioxidant levels significantly, which protect eyes from hypopigmentation and accumulation of oxidative stress compounds that can damage the macula.

«This results in oxidative damage to diaphragm proteins, leading to increased breakdown of proteins in the diaphragm and wasting (atrophy) of the fibers in the diaphragm,» said Ashley Smuder, PhD, lead author on the study.

Researchers find that a substance indicating oxidative damage increases in urine as people get older.

A new study finds that exposure to a widespread outdoor fungus can increase cell damage (oxidative stress) in the airways.

Her research team found that cellular oxidative stress (arising because of reactive oxygen species) increases in mice exposed to THS, damaging proteins, fats and DNA, and leading to hyperglycemia (excess glucose in the blood stream) and insulinemia (excess insulin in the blood)-- a condition also called insulin resistance.

These drugs have been found to increase oxidative stress (a type of cell damage), impair the body's ability to digest fat and damage blood vessels.

The mechanism of action here is thought to involve resistance to oxidative damage and increased quality control of damaged proteins.

Increased free radical induced oxidative stress plays a pivotal role in pathogenesis of many diseases including obesity, T2D and AP [7, 39 - 43] leading to macromolecular damage (DNA, protein and lipids), inflammation, ER stress and necrosis of acinar cells [44].

Increased stored iron could also promote oxidative stress / free radical damage in vulnerable neurons, a critical early change in AD.

This study showed that a P - CR diet did not lead to an increase in toxins or oxidative damage.

Sugar accelerates aging by increasing oxidative stress (cell damage caused by renegade molecules called free radicals).

Over time the amount of DNA / RNA diminish and become damaged due to increased oxidative stress and will consequently produce flawed copies of our own genetic blueprint.

Resveratrol activates sirtuins, which can increase insulin sensitivity and protect against oxidative damage.

When there are too many free radicals, the body is said to be in a state of oxidative stress, which can damage cells and increase the risk of many diseases including cancer and heart disease (3).

These two plant medicines have been shown to decrease oxidative cellular damage and increase cellular energy, paramount to overcoming brain fog.

This is likely due to the two factors listed above: increased autophagy and reduced oxidative damage / inflammation.

Prolonged increased stress to cells depletes the body's biological abilities to protect against oxidative damage.

And you know, the conventional view is that they have that higher risk because of higher levels of LDL, but actually the most recent research and our recent understanding of what causes both Alzheimer's and heart disease suggests that the reason they have a higher risk is that ApoE4 carriers are more susceptible to oxidative damage and inflammation, and it's the oxidation of the LDL particle that's the common thread in both increased risk of heart disease and increased risk of Alzheimer's and dementia.

Oxidative stress (an increase in free radicals and not enough antioxidants to counter the damage)

Aging - associated increases in oxidative damage to key enzymes results in their structural deformation and decreased binding affinity for the co-enzyme, causing a decrease in enzyme funtion.8 Ames» research has demonstrated that increasing the availability of acetyl L - carnitine and α - lipoic acid, two nutrients that serve as mitochondrial enzyme co-factors, restores the velocity of the reactions (KM) in the related enzymes, and thus restores aging mitochondria's ability to produce youthful levels of ATP.9 10 11 12 13 Part II focused on the inter-relationships among the folate, methylation and transsulfuration pathways, whose dysfunction results in increased free radical production coupled with disruption of glutathione (GSH) synthesis, thus accelerating mitochondrial decay and aging.

Recently, researchers from the Faculty of Science, School of Community Health, Charles Sturt University (New South Wales) have found that obesity, which increases blood glucose levels, contributes to oxidative DNA damage.

Oxidative damage to cells is often associated with increased risk of cancer, an adverse condition where cells grow beyond their normal boundaries and into other tissues.

Abnormal Krebs cycle and / or oxidative phosphorylation cause (s) not only glucose hypometabolism but also the increased generation of reactive oxygen species (ROS), oxidative damage, and programmed cell death such as apoptosis.

It inhibits cell replication, changes membrane structure, reduces the size of villi that absorb nutrients, and increases secretions that cause oxidative damage.

Glycated proteins and cellular structures have altered function, increased vulnerability to oxidative damage, and reduced degradation and clearance.6 Slowing the entry of glucose into the brain would delay these processes and possibly give the body's defenses more time to dispose of the AGEs.

In studies rosmarinic acid has been shown to increase oxygenation of brain tissues and help prevent damage from oxidative stress.

These changes occur as a result of increased oxidative stress, which is an imbalance between free radicals (unstable molecules that damage cells) and the body's ability to defend against them.

Oxidative stress can cause oxidative damage to large biomolecules such as proteins, DNA, and lipids, resulting in an increased risk for cancer and cardiovascular diseaseOxidative stress can cause oxidative damage to large biomolecules such as proteins, DNA, and lipids, resulting in an increased risk for cancer and cardiovascular diseaseoxidative damage to large biomolecules such as proteins, DNA, and lipids, resulting in an increased risk for cancer and cardiovascular disease (8, 10).

Free radicals are responsible for causing oxidative damage to your cells — they also increase your risk of developing cancer.

When paraoxonase activity increases, the lipids in the blood are better protected from the damaging influence of oxidative stress.

In a human study, 30 healthy individuals whose diets were supplemented with 500 mg vitamin C / d showed an increase of oxidative damage in the DNA isolated from lymphocytes (35).

Because much of the peripheral damage of cancer treatment is caused largely by oxidative stress and inflammation, increasing the body's antioxidant defense systems will drastically reduce side effects and limit suffering by the patient.

AAEM pointed to numerous animal studies that showed oxidative stress, altered structure and function of the liver, intestinal damage, disruption of the immune system, increased cell growth and hundreds of alterations in gene expressions.

This leads to increased cholesterol levels, decreased insulin sensitivity, and a decreased ability to prevent oxidative damage done to our bodies.

It ended up actually increasing oxidative lipid damage, which can lead to further vascular damage.

Homocysteine levels rise with age, and increasing levels can lead to a damaging chain reaction of effects — research has revealed that elevated homocysteine levels can disrupt delicate arterial linings, increase inflammation and oxidative stress, decrease blood flow to the heart and brain and set the stage for atherosclerosis and coronary artery disease.

There is increasing evidence that free radical - induced oxidative damage plays a significant role in the pathogenesis of Alzheimer's disease.

«The hypothesis that higher intake of plant foods is beneficial to human health because this increases antioxidant defence against oxidative damage is logical in evolutionary terms, especially when we consider the relatively hypoxic environment in which humans may have evolved.

The studies show that low level laser therapy (LLLT) used on acupuncture points on the neck and over the ovaries appears to enhance mitochondrial activity and ATP production, increase blood flow and helps to reduce oxidative damage.

Even though intense and exhaustive physical activity can contribute to oxidative damage, regular moderate exercise can increase your body's production of natural antioxidants, which help protect cells (29, 30).

T α 1 itself has been shown to exhibit antibacterial and antifungal properties, suppress tumor growth, increase vaccine effectiveness, and protect against oxidative damage.

Research has shown that supplementation of taurine increases muscular performance, exercise capacity, reduces lactate acid concentration during exercise, muscle damage and oxidative stress after exercise *.

Chronic stress promotes inflammation and oxidative damage that is inflicted upon DNA, which increases disease risk and accelerates aging.

Interestingly, evidence suggests that free radical and inflammatory cytokine production slow down during fasting and protective cytokine production increases and protects the brain from oxidative damage.

When there are too many free radicals, the body is said to be in a state of oxidative stress, which can damage cells and increase the risk of disease (3).