Sentences with phrase «increased oxidative stress level»

It also had increased oxidative stress level, which is toxic to the neuron.

Even compared to with inflammation, there is a TON of studies demonstrating that fluoride consumption can massively increase your oxidative stress levels.

Not exact matches

Results of the study showed that the total antioxidant capacity in the bloodstream of the participants increased, and that their level of oxidative stress (as measured by the amount of carboxymethyllysine in their blood serum) decreased.

One study published in the American Academy of Optometry's Optometry & Vision Science journal found that using goji berry daily as a dietary supplementation for 90 days increases plasma zeaxanthin and antioxidant levels significantly, which protect eyes from hypopigmentation and accumulation of oxidative stress compounds that can damage the macula.

They also assessed the potential relationship between oxidative stress, the degree of urbanization and parasitic infections to see whether increased infections are associated with increased stress levels.

We found the opposite — that antioxidant levels increased and oxidative stress decreased with increasing background radiation.»

In addition to improving endothelial function, the MitoQ treatment increased levels of nitric oxide, reduced oxidative stress and improved the health of the mitochondria in the arteries of old mice.

The research, published in PLOS ONE, found that several markers of insulin resistance were increased following sustained exposure (6 - 8 weeks) to hypoxia at high altitude and that this change was related to increased blood levels of markers of inflammation and oxidative stress.

While nicotine decreases appetite by affecting the brain and some hormone levels, it results also in increased oxidative stress.

«One potential approach is to target the folate pathway that melanoma cells use to survive oxidative stress, which would increase the level of oxidative stress in the cancer cells.»

In addition, inflammatory cytokines and transcription factors have also been shown to be upregulated in taurocholate - induced AP in obese zucker rats leading to increased oxidative stress, fat necrosis and isoprostanes levels, as compared to lean controls [7].

In addition, the team will study a promising link between these exosomes, reduced oxidative stress and increased antioxidant levels seen in treated brains, effects they hope also will lead to potential therapeutics for neurological diseases.

During periods of oxidative stress, as levels of reactive electrophilic metabolites increase, the ability of Keap1 to target Nrf2 for ubiquitin - dependent degradation is disrupted, thereby increasing Nrf2 protein levels and its transport into the nucleus, resulting in transcription of antioxidant response genes [5], [6], [8], [10], [11].

Enhanced amyloidogenic processing of APP by the ß - site APP cleaving enzyme (BACE) and the γ - secretase complex and reduced clearance lead to increased intracellular levels of soluble oligomeric Aß, resulting in cellular dysfunction comprising e.g., synaptic failure, mitochondrial dysfunction, enhanced oxidative stress, neurotransmitter and neurotrophin depletion, inflammation, and apoptosis which is reflected in patients as clinical symptoms such as cognitive deficits [2, 3].

The results indicate that the diabetic animals treated with MCW had decreased blood glucose levels and reduced oxidative stress induced by alloxan, which was evident from the increased activities of the antioxidant enzymes and the decreased levels of the lipid peroxidation products.

Aging of the retina is linked to increased oxidative damage levels, and oxidative stress is believed to play a crucial part in the development of age - related macular degeneration.

Stress resistance has not been assessed however and so the biological relevance of this finding is currently unknown.32 Several IER trials (75 - 85 % ER on restricted days) in overweight / obese populations have reported reductions in various markers of oxidative stress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research DireStress resistance has not been assessed however and so the biological relevance of this finding is currently unknown.32 Several IER trials (75 - 85 % ER on restricted days) in overweight / obese populations have reported reductions in various markers of oxidative stress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Direstress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Direlevels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research DireLevels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directions

Also noted by IER studies are an increase in the expression levels of silent mating type information regulation 2 homolog 1 (SIRT1), an NAD + - dependent deacetylase.20 The expression of SIRT1, also increased by prolonged ER in rodents, is linked to the up - regulation of cellular stress resistance and improved outcomes in animal models of metabolic, neurodegenerative and inflammatory diseases.106, 107These findings have been suggestively accompanied by improvements in resilience to disease progression in rodent models of Type 1 diabetic nephropathy 20, survival following induced ischaemic injury 21 and a reduction in oxidative stress.105

Several trials have demonstrated that the cardiomyocytes of rodents maintained on IER become more resilient to ischaemic injury induced by occlusion of the left coronary artery 18, 21, 29, which translated into improved long - term survival following such injury in one study.21 In addition, within these studies, associations have been found between the cardiovascular improvements and markers of oxidative stress 24, 30, inflammatory responses 18, 24, 29, 30 and increases in circulating levels of adiponectin.29 Collectively, these reported changes in biochemical and physiological cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve cardiovascular health.

With age, ROS - induced aberrant triggering of the insulin signaling mechanism in the postabsorptive state inhibits autophagy, preventing maintenance of plasma cysteine and intracellular glutathione levels throughout the night and early morning hours, and initiating a vicious cycle of progressively increasing oxidative stress and mitochondrial dysfunction.

For acne, low - level atrazine exposure has been linked to several diseases such as increased inflammation in rats (study) and higher oxidative stress in mice (study).

But in older individuals in whom basal levels of oxidative stress are already increased, aberrant insulin signaling during the fasting state that militates against mitophagy and further decreases glutathione stores, becomes the final straw.

Since α - hydroxybutyrate is a byproduct of GSH production, high levels indicate increased hepatic GSH synthesis due to chronic oxidative stress.

When this pathway breaks down it causes increased levels of oxidative stress within the cell that leads to the glutathione depletion and mitochondrial dysfunction (17).

The primary symptoms of diabetes include hypertension, elevated cholesterol levels, chronic inflammation and increased oxidative stress.

Of course, it would seem logical that, if increased oxidative stress is present in the AD patient, levels of key antioxidant nutrients would also be affected.

This results in elevated insulin levels, increased fat storage and increased oxidative stress and inflammatory conditions in the body.

In fact, according to an article published in Lipids and Health Disease, research indicates that not only do acne - prone individuals show signs of increased oxidative stress systemically (including lower blood levels of antioxidant vitamins like A and E), but also that oxidative stress may actually serve as «a match that lights an inflammatory cascade in acne.»

In fact, the bulk of the scientific evidence suggests that taking calcium supplements in the hope of getting strong bones and teeth, for instance, might well increase free radicals and oxidative stress levels.

By increasing your oxidative stress and depleting your vitamin C levels, for instance, you lose out on vitamin C's other acne - clearing powers whether it be lowered stress hormones or accelerated collagen production.

Consuming meat that has been cooked at very high temperatures and consuming fewer phytonutrient rich foods can lead to increased levels of oxidative stress.

Regardless of weight, women with PCOS have been shown to have higher levels of inflammatory markers such as increases in C - reactive protein (CRP), pro-inflammatory cytokines and chemokines, white blood cell count, oxidative stress, and various markers of endothelial inflammation.

Homocysteine levels rise with age, and increasing levels can lead to a damaging chain reaction of effects — research has revealed that elevated homocysteine levels can disrupt delicate arterial linings, increase inflammation and oxidative stress, decrease blood flow to the heart and brain and set the stage for atherosclerosis and coronary artery disease.

There's evidence that oxalates can deplete glutathione levels as well, and increase oxidative stress.

However, I definitely do not recommend that you minimise B12 in your diet because low levels can increase oxidative stress and cause sleep deprivation, and put you at risk of depression and brain problems.

American cancer researchers discovered that you can reduce oxidative stress by 15 percent by taking 45 minutes of daily exercise at a level that causes your maximal oxygen uptake to increase.

Evidence of oxidative stress was found in the mucosa of the small intestine of drug - treated rats, as indicated by significantly increased activity of xanthine oxidase (P < 0.001) and myeloperoxidase (P < 0.001), with corresponding decreases in the levels of several free radical scavenging enzymes and alpha - tocopherol (P < 0.001 in all cases).

As you may know, exposure to lead increases oxidative stress, interferes with the immune system and lowers glutathione levels — which is crucial for detoxification.

Third, increased levels of cytosolic DA and its metabolites can cause toxic oxidative stress.

Iron can be a very potent oxidative stress, so if you have excess iron levels you can damage your blood vessels and increase your risk of heart disease.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

Studies consistently show that smokers have lower plasma and leukocyte vitamin C levels than nonsmokers, due in part to increased oxidative stress [8].