Sentences with phrase «increased proliferative»

Not exact matches

These eyes also had almost a five-fold increased risk of progression to proliferative diabetic retinopathy, the most advanced form of the disease.

In addition, well - characterized expression profiles for melanoma cells have been identified that correlate highly proliferative cell states with increased expression for pathways regulated by the lineage - specific transcription factors SOX10 and MITF; conversely, migratory / invasive cell states have been correlated with TGFβ1 signaling pathways.

It has been shown in imatinib - resistant CML that drug resistance conferred by mutations does not necessarily correlate with proliferative advantage and increased kinase activity.34 Other, non-activating mutations or drug - resistance mechanisms, might be acquired by tumor cells.

Aging in humans is associated with increased infections and the reduced proliferative capacity of T cells, part of the more global phenomenon termed immune senescence.

«The intake of fiber and nuts during adolescence and incidence of proliferative benign breast disease» — such as fibrocystic breast disease; fibroadenomas; noncancerous breast lumps — but, is considered a marker for increased breast cancer risk.

The negative effects seem to lie in the capacity of some foods / nutrients to stimulate proliferative pathways that in turn stimulate development of acne — suspect foods include those with a high glycaemic load and milk.11, 43, 44 Other evidence comes from several studies reporting that the prevalence of acne varies significantly between different populations and is substantially lower in non-Westernized populations that follow traditional diets, 45 a common factor among these traditional diets being a low glycaemic load.46 Various studies have provided evidence that high - glycaemic - load diets are implicated in the aetiology of acne through their capacity to stimulate insulin, androgen bioavailability and insulin - like growth factor - 1 (IGF - 1) activity, whereas the beneficial effects of low - glycaemic - load diets, apart from weight and blood glucose levels, also include improved skin quality.44 The clinical and experimental evidence does in fact suggest ways in which insulin can increase androgen production and affect via induction of steroidogenic enzymes, 47 the secretion by the pituitary gland of gonadotropin - releasing hormone and the production of sex hormone - binding globulin.48 Insulin is also able to reduce serum levels of IGF - binding protein - 1 increasing the effect of IGF - 1.49 These insulin - mediated actions can therefore influence diverse factors that underlie the development of acne such as:

In highly proliferative lesions with increased Ki67, estrogen receptor was negative, but human epidermal growth factor receptor 2 was usually positive with a distribution that was similar to that reported for human intraepithelial lesions (7).