The amount of blood volume needed to be taken from a cat and their small size in combination with using a sedative may
increase the risk of an adverse reaction such as low blood pressure.
• increases the risk of cardiac hemangiosarcoma by a factor of 1.6 • triples the risk of hypothyroidism • increases the risk of progressive geriatric cognitive impairment • triples the risk of obesity, a common health problem in dogs with many associated health problems • quadruples the small risk (< 0.6 %) of prostate cancer • doubles the small risk (5; this is a common cancer and major cause of death in some breeds • triples the risk of hypothyroidism • increases the risk of obesity by a factor of 1.6 - 2, a common health problem in dogs with many associated health problems • causes urinary «spay incontinence» in 4 - 20 % of female dogs • increases the risk of persistent or recurring urinary tract infections by a factor of 3 - 4 • increases the risk of recessed vulva, vaginal dermatitis, and vaginitis, especially for female dogs spayed before puberty • doubles the small risk (< 1 %) of urinary tract tumors • increases the risk of orthopedic disorders •
increases the risk of adverse reactions to vaccinations One thing is clear — much of the spay / neuter information that is available to the public is unbalanced and contains claims that are exaggerated or unsupported by evidence.
In older animals, chest radiographs and electrocardiogram (ECG) are often recommended to ensure there is no pre-existing pathology in the heart or lungs that might
increase the risk of an adverse reaction.
Addition of an unnecessary antigen to the vaccination protocol will result in a lesser immunity to the important diseases like parvovirus and distemper, and
increase the risk of adverse reactions.
The use of Clomicalm Tablets in conjunction with certain other drugs or when your dog has other illnesses may be contraindicated or
increase the risks of adverse reactions.
In older animals, chest radiographs may be recommended to ensure that there is no pre-existing pathology in the heart or lungs that might
increase the risk of an adverse reaction.
Not exact matches
These
risks and uncertainties include, among others: the unfavorable outcome
of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any
of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components
of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence
of efficacy and adequacy
of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results
of our clinical development activities may not be positive, or predictive
of real - world results or
of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an
increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make
adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights
of third parties, or have unintended side effects,
adverse reactions or incidents
of misuse; and those
risks and uncertainties described under the heading «
Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.
Taking antibiotics when they are not needed creates additional health
risks as it
increases the chance a patient will experience an
adverse drug
reaction, and also leads to the development
of antibiotic - resistant bacteria which affects everyone in the community.
The
increased risk closely correlates with the frequency
of a gene variant previously associated with that
adverse reaction, supporting recommendations to screen for that variant in patients from those populations.
While prostate changes can occur with testosterone replacement, a study published in The Journal
of Clinical Endocrinology & Metabolism in June
of 2010, which looked closely at the
adverse reactions reported in 51 other studies, found there to be no
increased risk of the development
of prostate cancer, prostate related urinary symptoms, or elevated PSA (prostate specific antigen).
Cats metabolize some NSAIDs drugs more slowly than dogs, potentially
increasing the
risk of adverse drug
reactions.
Because vaccinating an animal which is already immune to a disease does not
increase their immunity but does in fact raise the
risk of adverse reactions, it is important to avoid over-vaccination.
Therefore, we should advise companion animal breeders and caregivers
of the potential for genetically susceptible littermates and relatives to be at
increased risk for similar
adverse vaccine
reactions (Dodds, 1997, 1999, 2001).
Dr. Schultz knows there's no benefit in over-vaccinating animals because immunity is not enhanced, but the
risk of harmful
adverse reactions is
increased.
«Administration
of multiple doses
of parenteral vaccine at the same appointment, particularly among small breed dogs (< 10 kg), may
increase the
risk of an acute - onset
adverse reaction.
Dr. Dodds feels the holistic veterinary community needs to document more case studies
of adverse reactions and do cohort reports so that DVMs have access to information about predisposing factors that
increase vaccine
risks for certain pets.