Using data gathered from the sessions, Grassi's team discovered
increased synaptic plasticity in the hippocampus, a region of the brain critical to memory processing and storage.
Not exact matches
They found that exercise may help cognition by
increasing blood and oxygen to the brain,
increasing levels of norepinephrine, and endorphins to decrease stress and improve mood, and
increasing growth factors that help create new nerve cells and support
synaptic plasticity.
This finding is in accordance with earlier animal model studies, which have shown that physical activity
increases the amount of growth factors in the brain and improves
synaptic plasticity.
They used a somewhat bizarre technique in which two mice were sutured together in such as way that they shared a circulatory system (known as parabiosis), and found old mice joined to their youthful counterparts showed changes in gene activity in a brain region called the hippocampus as well as
increased neural connections and enhanced «
synaptic plasticity» — a mechanism believed to underlie learning and memory in which the strength of neural connections change in response to experience.
Mal - gluc modulates histone acetylation of the Rac1 gene and allows transcription activators to access the DNA for
increased transcription in the brain, which influences the expression of genes responsible for
synaptic plasticity.
When the researchers modeled the effects in mice, they found it strengthened the connections between neurons that make learning possible — what is known as
synaptic plasticity — by
increasing the action of a cell receptor critical to forming memories.
Gross, C., Chang, C. - W., Kelly, S.M., Bhattacharya, A., McBride, S.M.J., Molinaro, G., Raj, N., Allen, A.G., Whyte, A.J., Danielson, S.W., Jiang, M.Q., Chan, C. - B., Ye, K., Gibson, J.R., Klann, E., Jongens, T.A., Moberg, K.H., Gourley, S.L., Huber, K.M., and Bassell, G.J. (2015)
Increased expression of the PI3K enhancer PIKE mediates deficits in
synaptic plasticity and behavior in fragile X syndrome.
Increased perfusion to brain tissue, decreased body weight, upregulation of growth factors and improved
synaptic plasticity may all be molecular mechanisms underlying the benefits of enrichment and activity therapies.